TgCRND8 Amyloid Precursor Protein Transgenic Mice Exhibit an Altered γ-Secretase Processing and an Aggressive, Additive Amyloid Pathology Subject to Immunotherapeutic Modulation†

Biochemistry ◽  
2007 ◽  
Vol 46 (36) ◽  
pp. 10317-10327 ◽  
Author(s):  
Gregory D. Van Vickle ◽  
Chera L. Esh ◽  
Walter M. Kalback ◽  
R. Lyle Patton ◽  
Dean C. Luehrs ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Amyloid Pathology

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human β-amyloid precursor protein transgenic mice

2004 ◽  
Vol 25 (10) ◽  
pp. 1315-1321 ◽  
Author(s):  
Joo-Yong Lee ◽  
Jonathan E. Friedman ◽  
Itzchak Angel ◽  
Alex Kozak ◽  
Jae-Young Koh
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Metal Chelator ◽  
Amyloid Pathology ◽  
Β Amyloid

Changes in Amyloid-  and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein

2013 ◽  
Vol 5 (194) ◽  
pp. 194re2-194re2 ◽  
Author(s):  
L. F. Maia ◽  
S. A. Kaeser ◽  
J. Reichwald ◽  
M. Hruscha ◽  
P. Martus ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein

scholarly journals Neuroprotective Effects of Asparagus officinalis Stem Extract in Transgenic Mice Overexpressing Amyloid Precursor Protein

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Zhanglong Peng ◽  
Supinder Bedi ◽  
Vivek Mann ◽  
Alamelu Sundaresan ◽  
Kohei Homma ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Caspase 3 ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Tau Proteins ◽  
Asparagus Officinalis ◽  
Mouse Strains ◽  
Neuroprotective Effects ◽  
Shock Proteins

To mimic Alzheimer’s disease, transgenic mice overexpressing the amyloid precursor protein (APP) were used in this study. We hypothesize that the neuroprotective effects of ETAS®50, a standardized extract of Asparagus officinalis stem produced by Amino Up Co., Ltd. (Sapporo, Japan), are linked to the inhibition of the apoptosis cascade through an enhancement of the stress-response proteins: heat shock proteins (HSPs). APP-overexpressing mice (double-transgenic APP and PS1 mouse strains with a 129s6 background), ages 6-8 weeks old, and weighing 20-24 grams were successfully bred in our laboratory. The animals were divided into 5 groups. APP-overexpressing mice and wild-type (WT) mice were pretreated with ETAS®50 powder (50% elemental ETAS and 50% destrin) at 200 mg/kg and 1000 mg/kg body weight. Saline, the vehicle for ETAS®50, was administered in APP-overexpressing mice and WT mice. ETAS®50 and saline were administered by gavage daily for 1 month. Cognitive assessments, using the Morris Water Maze, demonstrated that memory was recovered following ETAS®50 treatment as compared to nontreated APP mice. At euthanization, the brain was removed and HSPs, amyloid β, tau proteins, and caspase-3 were evaluated through immunofluorescence staining with the appropriate antibodies. Our data indicate that APP mice have cognitive impairment along with elevated amyloid β, tau proteins, and caspase-3. ETAS®50 restored cognitive function in these transgenic mice, increased both HSP70 and HSP27, and attenuated pathogenic level of amyloid β, tau proteins, and caspsase-3 leading to neuroprotection. Our results were confirmed with a significant increase in HSP70 gene expression in the hippocampus.

scholarly journals β-Secretase Processing of the β-Amyloid Precursor Protein in Transgenic Mice Is Efficient in Neurons but Inefficient in Astrocytes

1996 ◽  
Vol 271 (49) ◽  
pp. 31407-31411 ◽  
Author(s):  
Jun Zhao ◽  
Lisa Paganini ◽  
Lennart Mucke ◽  
Marissa Gordon ◽  
Larry Refolo ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Β Amyloid

Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in β-amyloid load

2005 ◽  
Vol 93 (2) ◽  
pp. 330-338 ◽  
Author(s):  
Dominique Santiard-Baron ◽  
Dominique Langui ◽  
Maryse Delehedde ◽  
Benoît Delatour ◽  
Brigitte Schombert ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Amyloid Load ◽  
Β Amyloid
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