scholarly journals Cytotoxic Ribonucleases:  The Dichotomy of Coulombic Forces†

Biochemistry ◽  
2007 ◽  
Vol 46 (36) ◽  
pp. 10308-10316 ◽  
Author(s):  
R. Jeremy Johnson ◽  
Tzu-Yuan Chao ◽  
Luke D. Lavis ◽  
Ronald T. Raines
Keyword(s):  
Cytotoxic Ribonucleases

Natural and Engineered Cytotoxic Ribonucleases: Therapeutic Potential

1999 ◽  
Vol 253 (2) ◽  
pp. 325-335 ◽  
Author(s):  
Susanna M. Rybak ◽  
Dianne L. Newton
Keyword(s):  
Therapeutic Potential ◽  
Cytotoxic Ribonucleases

scholarly journals Ribonucleases and Immunoribonucleases as Potential Modalities of Anticancer Therapy

2020 ◽  
pp. 1-8
Author(s):  
Piotr Smolewski ◽  
Monika Kowalik ◽  
Magdalena Witkowska ◽  
Piotr Smolewski
Keyword(s):  
Anticancer Agents ◽  
Antisense Oligonucleotides ◽  
Molecular Targets ◽  
Anticancer Therapy ◽  
Current Status ◽  
Malignant Cells ◽  
Antitumor Effects ◽  
Novel Approach ◽  
Cytotoxic Ribonucleases

A novel approach of antitumor treatment, that involves targeting RNA either using specific antisense oligonucleotides or cytostatic/cytotoxic ribonucleases (RNases), is being promoted. Among recently described cytotoxic RNases, amphibian RNases, including ranpirnase (onconase; ONC) and Amphinase (rAmph), are promising anticancer agents. They manifest strong antitumor effects and act synergistically with several cytostatics. Recently, rapidly developed proteins by engineering of RNases, displayed cytotoxic activity against several types of malignant cells. Most recent data show the role of microRNAs in mediating tumor progression, opening a new field of possible molecular targets for RNases. This review summarizes the current status of those RNases and immunoRNases as promising novel anticancer therapeutics.

scholarly journals A Study of the Intracellular Routing of Cytotoxic Ribonucleases

1995 ◽  
Vol 270 (29) ◽  
pp. 17476-17481 ◽  
Author(s):  
YouNeng Wu ◽  
Shailendra K. Saxena ◽  
Wojciech Ardelt ◽  
Massimo Gadina ◽  
Stanislaw M. Mikulski ◽  
...  
Keyword(s):  
Cytotoxic Ribonucleases

A hydrophobic segment of some cytotoxic ribonucleases

2013 ◽  
Vol 81 (2) ◽  
pp. 328-334 ◽  
Author(s):  
Fedor V. Shirshikov ◽  
Georgy V. Cherepnev ◽  
Olga N. Ilinskaya ◽  
Nataliya V. Kalacheva
Keyword(s):  
Cytotoxic Ribonucleases
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