A Complex Mechanism for Inducer Mediated Tau Polymerization†

Biochemistry ◽  
2007 ◽  
Vol 46 (30) ◽  
pp. 8838-8849 ◽  
Author(s):  
Shaun W. Carlson ◽  
Mike Branden ◽  
Kellen Voss ◽  
Qian Sun ◽  
Carolyn A. Rankin ◽  
...  
Keyword(s):  
Complex Mechanism ◽  
Tau Polymerization

Kinetics of the Thermal Disappearance of Radicals Formed During the Radiolysis of Aspartic Acid

2009 ◽  
Vol 59 (12) ◽  
Author(s):  
Mihai Contineanu ◽  
iulia Contineanu ◽  
Ana Neacsu ◽  
Stefan Perisanu
Keyword(s):  
Thermal Resistance ◽  
Aspartic Acid ◽  
Room Temperature ◽  
Esr Spectra ◽  
Complex Mechanism ◽  
Radical Species ◽  
Mechanisms Of Formation ◽  
Kinetics Of

The radiolysis of the isomers L-, D- and DL- of the aspartic acid, in solid polycrystalline state, was investigated at room temperature. The analysis of their ESR spectra indicated the formation of at least two radicalic entities. The radical, identified as R3, resulting from the deamination of the acid, exhibits the highest concentration and thermal resistance. Possible mechanisms of formation of three radical species are suggested, based also on literature data. The kinetics of the disappearance of radical R3 indicated a complex mechanism. Three possible variants were suggested for this mechanism.

scholarly journals A multi-omics view of the complex mechanism of vascular calcification

2021 ◽  
Vol 135 ◽  
pp. 111192
Author(s):  
Yongjiang Qian ◽  
Lihua Li ◽  
Zhen Sun ◽  
Jia Liu ◽  
Wei Yuan ◽  
...  
Keyword(s):  
Vascular Calcification ◽  
Complex Mechanism

The kinetics of the decarboxylation of β-resorcylic acid in catechol

1976 ◽  
Vol 29 (2) ◽  
pp. 443 ◽  
Author(s):  
MA Haleem ◽  
MA Hakeem
Keyword(s):  
Rate Equation ◽  
Kinetic Data ◽  
Reaction Rate ◽  
Complex Mechanism ◽  
First Order ◽  
Absolute Reaction Rate ◽  
First Time ◽  
Kinetics Of ◽  
Absolute Reaction ◽  
Reaction Rate Equation

Kinetic data are reported for the decarboxylation of β-resorcylic acid in resorcinol and catechol for the first time. The reaction is first order. The observation supports the view that the decomposition proceeds through an intermediate complex mechanism. The parameters of the absolute reaction rate equation are calculated.

Pyrolysis of ethane in the presence of hydrogen sulfide. Rates of formation of ethylene, hydrogen, and methane

1970 ◽  
Vol 48 (11) ◽  
pp. 1782-1785 ◽  
Author(s):  
P. R. McLean ◽  
D. J. McKenney
Keyword(s):  
Thermal Decomposition ◽  
Hydrogen Sulfide ◽  
Quantitative Data ◽  
Methane Formation ◽  
Partial Product ◽  
Complex Mechanism ◽  
Product Analysis ◽  
Hydrogen Formation

Rates of formation of ethylene, hydrogen, and methane have been measured at 630 °C for the thermal decomposition of ethane at pressures between 100 and 620 Torr, with various pressures (approximately 1 to 100 Torr) of added hydrogen sulfide. The effect of the H2S was to increase the rate of methane formation and to decrease the rate of ethylene and hydrogen formation. Rates of formation of all three of these gases decreased with increasing hydrogen sulfide pressures. The quantitative data obtained and the partial product analysis indicate that a complex mechanism is operative. Possible qualitative explanations for the observations are discussed.

scholarly journals Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Giovanna Cacciola ◽  
Teresa Chioccarelli ◽  
Silvia Fasano ◽  
Riccardo Pierantoni ◽  
Gilda Cobellis
Keyword(s):  
Cannabinoid Receptor ◽  
Morphological Changes ◽  
Terminal Differentiation ◽  
Environmental Chemicals ◽  
Complex Mechanism ◽  
Autocrine Factors ◽  
Estrogenic Effects ◽  
Male Gametes ◽  
Type 1 Cannabinoid Receptor

Spermatogenesis is a complex mechanism which allows the production of male gametes; it consists of mitotic, meiotic, and differentiation phases. Spermiogenesis is the terminal differentiation process during which haploid round spermatids undergo several biochemical and morphological changes, including extensive remodelling of chromatin and nuclear shape. Spermiogenesis is under control of endocrine, paracrine, and autocrine factors, like gonadotropins and testosterone. More recently, emerging pieces of evidence are suggesting that, among these factors, estrogens may have a role. To date, this is a matter of debate and concern because of the agonistic and antagonistic estrogenic effects that environmental chemicals may have on animal and human with damaging outcome on fertility. In this review, we summarize data which fuel this debate, with a particular attention to our recent results, obtained using type 1 cannabinoid receptor knockout male mice as animal model.

Translocation (10;11)(p12;q23) in childhood acute myeloid leukemia: incidence and complex mechanism

2006 ◽  
Vol 169 (2) ◽  
pp. 114-120 ◽  
Author(s):  
Irina Stasevich ◽  
Regina Utskevich ◽  
Anatoly Kustanovich ◽  
Natallia Litvinko ◽  
Tatsiana Savitskaya ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Complex Mechanism ◽  
Childhood Acute Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Direct Digital Simulation of the Steady-State Limiting Current at a Rotating Disk Electrode for a Complex Mechanism.

1992 ◽  
Vol 46 ◽  
pp. 949-955 ◽  
Author(s):  
Henrik Balslev ◽  
Dieter Britz ◽  
Géza Stájer ◽  
Samuel Frimpong-Manso ◽  
Johan Springborg ◽  
...  
Keyword(s):  
Steady State ◽  
Digital Simulation ◽  
Rotating Disk ◽  
Rotating Disk Electrode ◽  
Limiting Current ◽  
Complex Mechanism ◽  
Disk Electrode

scholarly journals Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology and Target Identification of Thio-wurtzine, a Potent Inhibitor of the Opioid Receptors and the Voltage-Dependent Calcium Channels

2021 ◽  
Author(s):  
Stephanie Aguero ◽  
Simon Megy ◽  
Raphael Terreux ◽  
Mailys Fournier ◽  
Daria Kulagina ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Opioid Receptors ◽  
Mechanism Of Action ◽  
Pain Treatment ◽  
Target Identification ◽  
Animal Experiments ◽  
Complex Mechanism ◽  
Narcotic Analgesics ◽  
Voltage Dependent

The number of candidate molecules for new non-narcotic analgesics is extremely limited. Here we report the identification of thiowurtzine, a new potent analgesic molecule with promising application in chronic pain treatment. We describe the chemical synthesis of this unique compound derived from the hexaazaisowurtzitane (CL-20) explosive molecule. Then we use animal experiments to assess its analgesic activity in vivo upon chemical, thermal and mechanical exposures, compared to the effect of several reference drugs. Finally, we investigate the potential receptors of thiowurtzine in order to better understand its complex mechanism of action. We use docking, molecular modeling and molecular dynamics simula-tions to identify and characterize the potential targets of the drug and confirm the results of the animal experiments. Our findings finally indicate that thiowurtzine may have a complex mechanism of action, by targeting the mu, kappa, delta and ORL1 opioid receptors, and the voltage-gated calcium channels as well.

scholarly journals Errors of Derived Proofs and Evaluation of Their Evidentiary Value

2020 ◽  
pp. 124-127
Author(s):  
Mikhail Georgievich Musaelyan
Keyword(s):  
Evidence Base ◽  
Complex Mechanism ◽  
Original Source ◽  
Legal Fact ◽  
Source Of Information

The emergence of derivative evidence is d to the mechanism of reflection of the legal fact used in the proof process and in the elements mediated in rela-tion to it. Complex mechanism reflection of the orig-inal evidence in copies derived from it, raise the question of the need to develop a mechanism for scientific determination of the degree of loss of a copy of its exact evidentiary value. The study of this problem is aimed at achieving maximum objectivity in assessing the derivative evidence, taking into account the errors of its compliance with the origi-nal evidence. The possible loss of the original evi-dentiary value of the estimated legal fact by the de-rivative evidence is usually caused by objective and subjective circumstances, the study and minimiza-tion of which will make the establishment of the circumstances of the case, where derivative evi-dence is used, more objective. The paper presents the author’s proposals for organizing the process of proving in order to preserve the coincidence of the features of the initial and derivative evidence: fixing the process of forming derivative evidence in proce-dural documents; involvement of forensic special-ists in the assessment of the obtained copies of evidence; production of forensic examinations. It is summarized that the introduction of proposals into practice will allow avoiding the loss of the evidence base due to the discrepancy between derived evi-dence and the original source of information.

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