Development of Indolequinone Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1):  NQO1 Inhibition and Growth Inhibitory Activity in Human Pancreatic MIA PaCa-2 Cancer Cells†

Biochemistry ◽  
2007 ◽  
Vol 46 (20) ◽  
pp. 5941-5950 ◽  
Author(s):  
Philip Reigan ◽  
Marie A. Colucci ◽  
David Siegel ◽  
Aurélie Chilloux ◽  
Christopher J. Moody ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Inhibitory Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

Indole-3-carbinol inhibits the proliferation of colorectal carcinoma LoVo cells through activation of the apoptotic signaling pathway

2021 ◽  
pp. 096032712110214
Author(s):  
JY Lee ◽  
HM Lim ◽  
CM Lee ◽  
S-H Park ◽  
MJ Nam
Keyword(s):  
Colorectal Carcinoma ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Annexin V ◽  
Fluorescein Isothiocyanate ◽  
Cell Counting ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Lovo Cells

Indole-3-carbinol (I3C) is a phytochemical that exhibits growth-inhibitory activity against various cancer cells. However, there are limited studies on the effects of I3C on colon cancer cells. In this study, the growth-inhibitory activity of I3C against the human colorectal carcinoma cell line (LoVo) was examined. The results of the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, colony formation, and cell counting assays revealed that I3C suppressed the proliferation of LoVo cells. Microscopy and wound-healing analyses revealed that I3C affected the morphology and inhibited the migration of LoVo cells, respectively. I3C induced apoptosis and DNA fragmentation as evidenced by the results of fluorescein isothiocyanate-conjugated annexin V staining and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling assay, respectively. Additionally, I3C arrested the cell cycle at the G0/G1 phase and enhanced the reactive oxygen species levels. Western blotting analysis revealed that treatment with I3C resulted in the activation of apoptotic proteins, such as poly(ADP-ribose) polymerase, caspase-3, caspase-7, caspase-9, Bax, Bim, and p53 in LoVo cells. These results indicate that I3C induces apoptosis in LoVo cells by upregulating p53, leading to the activation of Bax and caspases. Taken together, I3C exerts cytotoxic effects on LoVo cells by activating apoptosis.

Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231)

Steroids ◽  
2016 ◽  
Vol 115 ◽  
pp. 90-97 ◽  
Author(s):  
Mahmoud Aghaei ◽  
Zeinab Yazdiniapour ◽  
Mustafa Ghanadian ◽  
Behzad Zolfaghari ◽  
Virginia Lanzotti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Breast Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Apoptotic Effects ◽  
Mcf 7

Sulfasalazine-Induced Reduction of Glutathione Levels in Breast Cancer Cells: Enhancement of Growth-Inhibitory Activity of Doxorubicin

Chemotherapy ◽  
2007 ◽  
Vol 53 (3) ◽  
pp. 210-217 ◽  
Author(s):  
Vishal S. Narang ◽  
Giovanni M. Pauletti ◽  
Peter W. Gout ◽  
Donna J. Buckley ◽  
Arthur R. Buckley
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Breast Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

Total Synthesis of Isoprekinamycin:  Structural Evidence for Enhanced Diazonium Ion Character and Growth Inhibitory Activity toward Cancer Cells

2007 ◽  
Vol 9 (15) ◽  
pp. 2915-2918 ◽  
Author(s):  
Wei Liu ◽  
Matthew Buck ◽  
Nan Chen ◽  
Muhong Shang ◽  
Nicholas J. Taylor ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Diazonium Ion

Growth inhibitory activity of lemnabourside on human prostate cancer cells

Life Sciences ◽  
2002 ◽  
Vol 70 (7) ◽  
pp. 843-853 ◽  
Author(s):  
W.K. Liu ◽  
N.L.Y. Wong ◽  
H.M. Huang ◽  
J.K.C. Ho ◽  
W.H. Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells

2008 ◽  
Vol 16 (6) ◽  
pp. 3445-3455 ◽  
Author(s):  
Ioannis K. Kostakis ◽  
Nicole Pouli ◽  
Panagiotis Marakos ◽  
Olga Ch. Kousidou ◽  
Andreas Roussidis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Breast Cancer Cells ◽  
Design Synthesis ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

scholarly journals Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cells

Phytomedicine ◽  
2008 ◽  
Vol 15 (6-7) ◽  
pp. 504-511 ◽  
Author(s):  
Linda Saxe Einbond ◽  
Ye Wen-Cai ◽  
Kan He ◽  
Hsan-au Wu ◽  
Erica Cruz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity
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