Heat-Triggered Conversion of Protofibrils into Mature Amyloid Fibrils of β2-Microglobulin†

Biochemistry ◽  
2007 ◽  
Vol 46 (11) ◽  
pp. 3286-3293 ◽  
Author(s):  
Kenji Sasahara ◽  
Hisashi Yagi ◽  
Hironobu Naiki ◽  
Yuji Goto
Keyword(s):  
Amyloid Fibrils ◽  
Β2 Microglobulin

scholarly journals Investigation into the Role of Macrophages in the Formation and Degradation of β2-Microglobulin Amyloid Fibrils

2007 ◽  
Vol 282 (40) ◽  
pp. 29691-29700 ◽  
Author(s):  
Isobel J. Morten ◽  
Walraj S. Gosal ◽  
Sheena E. Radford ◽  
Eric W. Hewitt
Keyword(s):  
Amyloid Fibrils ◽  
Β2 Microglobulin

scholarly journals Advanced Glycation End Product-Modified β2-Microglobulin is a Component of Amyloid Fibrils of Primary Localized Cutaneous Nodular Amyloidosis

2002 ◽  
Vol 118 (3) ◽  
pp. 479-484 ◽  
Author(s):  
Norihiro Fujimoto ◽  
Mayumi Yajima ◽  
Yoshihiro Ohnishi ◽  
Shingo Tajima ◽  
Akira Ishibashi ◽  
...  
Keyword(s):  
Amyloid Fibrils ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Β2 Microglobulin

Thermal Response with Exothermic Effects of β2-Microglobulin Amyloid Fibrils and Fibrillation

2009 ◽  
Vol 389 (3) ◽  
pp. 584-594 ◽  
Author(s):  
Kenji Sasahara ◽  
Hisashi Yagi ◽  
Hironobu Naiki ◽  
Yuji Goto
Keyword(s):  
Amyloid Fibrils ◽  
Thermal Response ◽  
Β2 Microglobulin

Kinetic analysis of the polymerization and depolymerization of β2-microglobulin-related amyloid fibrils in vitro

2005 ◽  
Vol 1753 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Suguru Yamamoto ◽  
Kazuhiro Hasegawa ◽  
Itaru Yamaguchi ◽  
Yuji Goto ◽  
Fumitake Gejyo ◽  
...  
Keyword(s):  
Kinetic Analysis ◽  
Amyloid Fibrils ◽  
Β2 Microglobulin

scholarly journals Conformation of Amyloid Fibrils of β2-Microglobulin Probed by Tryptophan Mutagenesis

2006 ◽  
Vol 281 (41) ◽  
pp. 31061-31069 ◽  
Author(s):  
Miho Kihara ◽  
Eri Chatani ◽  
Kentaro Iwata ◽  
Kaori Yamamoto ◽  
Takanori Matsuura ◽  
...  
Keyword(s):  
Amyloid Fibrils ◽  
Β2 Microglobulin

Kinetically Controlled Thermal Response of β2-Microglobulin Amyloid Fibrils

2005 ◽  
Vol 352 (3) ◽  
pp. 700-711 ◽  
Author(s):  
Kenji Sasahara ◽  
Hironobu Naiki ◽  
Yuji Goto
Keyword(s):  
Amyloid Fibrils ◽  
Thermal Response ◽  
Β2 Microglobulin ◽  
Kinetically Controlled

Proteomics of β2-microglobulin amyloid fibrils

2005 ◽  
Vol 1753 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Monica Stoppini ◽  
Palma Mangione ◽  
Maria Monti ◽  
Sofia Giorgetti ◽  
Loredana Marchese ◽  
...  
Keyword(s):  
Amyloid Fibrils ◽  
Β2 Microglobulin

scholarly journals Detection of fragments of β2-microglobulin in amyloid fibrils

2000 ◽  
Vol 57 (1) ◽  
pp. 349-350 ◽  
Author(s):  
Monica Stoppini ◽  
Patrizia Arcidiaco ◽  
Palma Mangione ◽  
Sofia Giorgetti ◽  
Diego Brancaccio ◽  
...  
Keyword(s):  
Amyloid Fibrils ◽  
Β2 Microglobulin

β2-Microglobulin and Renal Bone Disease

1999 ◽  
Vol 19 (2_suppl) ◽  
pp. 413-416 ◽  
Author(s):  
Takehiko Wada ◽  
Toshio Miyata ◽  
Hideto Sakai ◽  
Kiyoshi Kurokawa
Keyword(s):  
Amyloid Fibrils ◽  
Imaging Techniques ◽  
Major Constituent ◽  
Carbonyl Stress ◽  
Surgical Removal ◽  
Β2 Microglobulin ◽  
Amyloid Deposits ◽  
Renal Bone Disease ◽  
Tunnel Syndrome ◽  
Stress Therapy

Dialysis-related amyloidosis (DRA) is characterized by amyloid deposition mainly in bone and joint structures, presenting as carpal tunnel syndrome, destructive arthropathy, and subchondral bone erosions and cysts. β2-microglobulin has been demonstrated to be a major constituent of amyloid fibrils. DRA occurs not only in patients undergoing long-term hemodialysis, but also in patients undergoing continuous ambulatory peritoneal dialysis. The incidence of this complication increases with the duration of dialytic therapy and the age of the patient. While a definitive diagnosis of DRA can be made only by histological findings, various imaging techniques often support diagnosis. The molecular pathogenesis of this complication remains unknown. Recent studies have, however, suggested a pathogenic role of a new modification of β2-microglobulin in amyloid fibrils -that is, the advanced glycation end-products (AGEs) formed with carbonyl compounds derived from autoxidation of both carbohydrates and lipids (“carbonyl stress”). Therapy for DRA is limited to symptomatic approaches and surgical removal of amyloid deposits. High-flux biocompatible dialysis membranes could be used to delay DRA development.

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