scholarly journals A Protective Antigen Mutation Increases the pH Threshold of Anthrax Toxin Receptor 2-Mediated Pore Formation

Biochemistry ◽  
2014 ◽  
Vol 53 (13) ◽  
pp. 2166-2171 ◽  
Author(s):  
Melissa K. Dennis ◽  
Jeremy Mogridge
Keyword(s):  
Pore Formation ◽  
Protective Antigen ◽  
Anthrax Toxin ◽  
Toxin Receptor ◽  
Anthrax Toxin Receptor 2

scholarly journals Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation

2004 ◽  
Vol 101 (36) ◽  
pp. 13147-13151 ◽  
Author(s):  
D. B. Lacy ◽  
D. J. Wigelsworth ◽  
R. A. Melnyk ◽  
S. C. Harrison ◽  
R. J. Collier
Keyword(s):  
Pore Formation ◽  
Protective Antigen ◽  
Anthrax Toxin ◽  
Toxin Receptor ◽  
Ph Dependent

scholarly journals Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation

PLoS ONE ◽  
2007 ◽  
Vol 2 (3) ◽  
pp. e329 ◽  
Author(s):  
Heather M. Scobie ◽  
John M. Marlett ◽  
G. Jonah A. Rainey ◽  
D. Borden Lacy ◽  
R. John Collier ◽  
...  
Keyword(s):  
Pore Formation ◽  
Anthrax Toxin ◽  
Toxin Receptor ◽  
Anthrax Toxin Receptor 2

scholarly journals Anthrax toxin receptor 2 promotes human uterine smooth muscle cell viability, migration and contractility

2014 ◽  
Vol 210 (2) ◽  
pp. 154.e1-154.e8 ◽  
Author(s):  
Joy Yumiko Vink ◽  
Pelisa Cheryll Charles-Horvath ◽  
Jan Krzysztof Kitajewski ◽  
Claire Vech Reeves
Keyword(s):  
Smooth Muscle ◽  
Cell Viability ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Anthrax Toxin ◽  
Uterine Smooth Muscle ◽  
Toxin Receptor ◽  
Anthrax Toxin Receptor 2

Systemic Hyalinosis: A Distinctive Early Childhood-Onset Disorder Characterized by Mutations in the Anthrax Toxin Receptor 2 Gene (ANTRX2)

PEDIATRICS ◽  
2006 ◽  
Vol 118 (5) ◽  
pp. e1485-e1492 ◽  
Author(s):  
J. T.C. Shieh ◽  
P. Swidler ◽  
J. A. Martignetti ◽  
M. C. M. Ramirez ◽  
I. Balboni ◽  
...  
Keyword(s):  
Early Childhood ◽  
Anthrax Toxin ◽  
Childhood Onset ◽  
Toxin Receptor ◽  
Anthrax Toxin Receptor 2

scholarly journals Differential expression of anthrax toxin receptor 2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Anthrax Toxin ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Toxin Receptor ◽  
Anthrax Toxin Receptor 2

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding anthrax toxin receptor 2, ANTXR2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ANTXR2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ANTXR2 in primary tumors of the breast was correlated with post-progression survival in patients with basal subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. ANTXR2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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