scholarly journals Strength of Axial Water Ligation in Substrate-Free Cytochrome P450s Is Isoform Dependent

Biochemistry ◽  
2014 ◽  
Vol 53 (9) ◽  
pp. 1428-1434 ◽  
Author(s):  
Kip P. Conner ◽  
Alina M. Schimpf ◽  
Alex A. Cruce ◽  
Kirsty J. McLean ◽  
Andrew W. Munro ◽  
...  
Keyword(s):  
Cytochrome P450s ◽  
Water Ligation

Enzymatic dimerization in the biosynthetic pathway of microbial natural products

2021 ◽  
Author(s):  
Jiawang Liu ◽  
Anan Liu ◽  
Youcai Hu
Keyword(s):  
Natural Products ◽  
Biosynthetic Pathway ◽  
Structural Diversity ◽  
Cytochrome P450s ◽  
Microbial Natural Products

Cytochrome P450s, laccases, and intermolecular [4 + 2] cyclases, along with other enzymes were utilized to catalyze varied dimerization of matured natural products so as to create the structural diversity and complexity in microorganisms.

scholarly journals Transcriptome-Based Identification and Molecular Evolution of the Cytochrome P450 Genes and Expression Profiling under Dimethoate Treatment in Amur Stickleback (Pungitius sinensis)

Animals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 873 ◽  
Author(s):  
Jun Cao ◽  
Xiuzhu Cheng
Keyword(s):  
Expression Profiling ◽  
Transcriptome Sequencing ◽  
Cell Metabolism ◽  
Functional Divergence ◽  
Expression Patterns ◽  
Cytochrome P450s ◽  
Cytochrome P450 Genes ◽  
Membrane Bound ◽  
Functional Relevance ◽  
Functional Investigation

Cytochrome P450s (CYPs) are a family of membrane-bound mono-oxygenase proteins, which are involved in cell metabolism and detoxification of various xenobiotic substances. In this study, we identified 58 putative CYP genes in Amur stickleback (Pungitius sinensis) based on the transcriptome sequencing. Conserved motif distribution suggested their functional relevance within each group. Some present recombination events have accelerated the evolution of this gene family. Moreover, a few positive selection sites were identified, which may have accelerated the functional divergence of this family of proteins. Expression patterns of these CYP genes were investigated and indicated that most were affected by dimethoate treatment, suggesting that CYPs were involved in the detoxication of dimethoate. This study will provide a foundation for the further functional investigation of CYP genes in fishes.

Identification of cytochrome P450s involved in the metabolism of arachidonic acid in human platelets

2013 ◽  
Vol 89 (4) ◽  
pp. 227-234 ◽  
Author(s):  
Yazun B. Jarrar ◽  
Sun-Ah Cho ◽  
Kyung-Suk Oh ◽  
Dong-Hyun Kim ◽  
Jae-Gook Shin ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Human Platelets ◽  
Cytochrome P450s

Genotoxicity of tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s

1994 ◽  
Vol 15 (1) ◽  
pp. 5-9 ◽  
Author(s):  
J. A. Styles ◽  
A. Davies ◽  
C. K. Lim ◽  
F. De Matteis ◽  
L. A. Stanley ◽  
...  
Keyword(s):  
Cytochrome P450s ◽  
Lymphoblastoid Cells ◽  
Human Cytochrome
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