scholarly journals HHM Motif at the CuH-Site of Peptidylglycine Monooxygenase is a pH-Dependent Conformational Switch

Biochemistry ◽  
2013 ◽  
Vol 52 (15) ◽  
pp. 2586-2596 ◽  
Author(s):  
Chelsey D. Kline ◽  
Mary Mayfield ◽  
Ninian J. Blackburn
Keyword(s):  
Conformational Switch ◽  
Peptidylglycine Monooxygenase ◽  
Ph Dependent

Innate immune sensing: Ligand recognition by M-ficolin is subject to a pH-dependent conformational switch

2007 ◽  
Vol 44 (16) ◽  
pp. 3928-3929 ◽  
Author(s):  
Virginie Garlatti ◽  
Lydie Martin ◽  
Evelyne Gout ◽  
Jean-Baptiste Reiser ◽  
Teizo Fujita ◽  
...  
Keyword(s):  
Innate Immune ◽  
Ligand Recognition ◽  
Conformational Switch ◽  
Ph Dependent ◽  
Immune Sensing ◽  
Innate Immune Sensing

A pH-Dependent Conformational Switch Controls N. meningitidis ClpP Protease Function

2020 ◽  
Vol 142 (49) ◽  
pp. 20519-20523
Author(s):  
Zev A. Ripstein ◽  
Siavash Vahidi ◽  
John L. Rubinstein ◽  
Lewis E. Kay
Keyword(s):  
Conformational Switch ◽  
Ph Dependent

scholarly journals A Copper–Methionine Interaction Controls the pH-Dependent Activation of Peptidylglycine Monooxygenase

Biochemistry ◽  
2011 ◽  
Vol 50 (50) ◽  
pp. 10819-10828 ◽  
Author(s):  
Andrew T. Bauman ◽  
Brenda A. Broers ◽  
Chelsey D. Kline ◽  
Ninian J. Blackburn
Keyword(s):  
Peptidylglycine Monooxygenase ◽  
Ph Dependent

scholarly journals pH-dependent conformational switch activates the inhibitor of transcription elongation

2006 ◽  
Vol 25 (10) ◽  
pp. 2131-2141 ◽  
Author(s):  
Oleg Laptenko ◽  
Seung-Sup Kim ◽  
Jookyung Lee ◽  
Marina Starodubtseva ◽  
Fellipe Cava ◽  
...  
Keyword(s):  
Transcription Elongation ◽  
Conformational Switch ◽  
Ph Dependent

scholarly journals Author response: Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

2019 ◽  
Author(s):  
Andrew Tze Fui Liew ◽  
Yong Hwee Foo ◽  
Yunfeng Gao ◽  
Parisa Zangoui ◽  
Moirangthem Kiran Singh ◽  
...  
Keyword(s):  
Single Cell ◽  
Super Resolution ◽  
Author Response ◽  
Conformational Switch ◽  
Acid Ph ◽  
Resolution Imaging ◽  
Ph Dependent

scholarly journals The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain

2015 ◽  
Vol 427 (2) ◽  
pp. 433-442 ◽  
Author(s):  
Sandra Hoefgen ◽  
Sven O. Dahms ◽  
Kathrin Oertwig ◽  
Manuel E. Than
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Conformational Switch ◽  
Ph Dependent

The Reaction of Thiol Compounds with the Vitamin-K Dependent Clotting Factors

1969 ◽  
Vol 21 (03) ◽  
pp. 573-579 ◽  
Author(s):  
P Fantl
Keyword(s):  
Prothrombin Time ◽  
Vitamin K ◽  
Anaerobic Conditions ◽  
Clotting Factors ◽  
Thiol Compounds ◽  
Aerobic Conditions ◽  
One Stage ◽  
Factor Ii ◽  
Ph Dependent ◽  
The One

SummaryTreatment of human and dog oxalated plasma with 0.2 to 1.0 × 10−1 M 2.3-dithiopropanol (BAL) or dithiothreitol (DTT) at 2–4° C for 30 min results in the reduction of the vitamin-K dependent clotting factors II, VII, IX and X to the respective-SH derivatives. The reaction is pH dependent. Under aerobic conditions the delayed one stage prothrombin time can be partly reversed. Under anaerobic conditions a gradual prolongation of the one stage prothrombin time occurs without reversal.In very diluted plasma treated with the dithiols, prothrombin can be converted into thrombin if serum as source of active factors VII and X is added. In contrast SH factors VII, IX and X are inactive in the specific tests. Reoxidation to active factors II, VII, IX and X takes place during adsorption and elution of the SH derivatives. The experiments have indicated that not only factor II but also factors VII, IX and X have active-S-S-centres.

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