scholarly journals Inducible Alkylation of DNA by a Quinone Methide–Peptide Nucleic Acid Conjugate

Biochemistry ◽  
2012 ◽  
Vol 51 (5) ◽  
pp. 1020-1027 ◽  
Author(s):  
Yang Liu ◽  
Steven E. Rokita
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Quinone Methide ◽  
Acid Conjugate

DNA Binding and Cleavage by a Cationic Manganese Porphyrin−Peptide Nucleic Acid Conjugate

1997 ◽  
Vol 8 (3) ◽  
pp. 267-270 ◽  
Author(s):  
Pascal Bigey ◽  
Søren Holst Sönnichsen ◽  
Bernard Meunier ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Peptide Nucleic Acid ◽  
Manganese Porphyrin ◽  
Acid Conjugate ◽  
Dna Binding And Cleavage

scholarly journals ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives

2017 ◽  
Vol 7 (2) ◽  
pp. 20160117 ◽  
Author(s):  
Kurt Hoogewijs ◽  
Andrew M. James ◽  
Robin A. J. Smith ◽  
Frank Abendroth ◽  
Michael J. Gait ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Click Chemistry ◽  
Peptide Nucleic Acid ◽  
Mitochondrial Matrix ◽  
Major Difficulty ◽  
Mitochondrial Membranes ◽  
Mitochondrial Import ◽  
Acid Conjugate ◽  
Multiple Molecules

There is an increasing interest in targeting molecules to the mitochondrial matrix. Many proteins are naturally imported through the translocase complexes found in the outer and inner mitochondrial membranes. One possible means for importing molecules is therefore to use a mitochondrial pre-protein as a vector and assess what forms of molecules can be attached to the pre-protein as cargo. A major difficulty with this approach is to ensure that any chimaeric molecule does indeed access the mitochondrial matrix and does not merely associate with the mitochondrial membranes. We have recently demonstrated that click chemistry can be used both to demonstrate convincingly mitochondrial import of a peptide–peptide nucleic acid conjugate and also to quantify the mitochondrial uptake for specific synthetic conjugates. We now report an adaptation of the synthesis to facilitate simple quantification of multiple molecules and hence to calculate the efficiency of their mitochondrial import.

Activatable Cell Penetrating Peptide–Peptide Nucleic Acid Conjugate via Reduction of Azobenzene PEG Chains

2014 ◽  
Vol 136 (37) ◽  
pp. 12868-12871 ◽  
Author(s):  
Soo Hyeon Lee ◽  
Elena Moroz ◽  
Bastien Castagner ◽  
Jean-Christophe Leroux
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Acid Conjugate

Gene delivery by a steroid‐peptide nucleic acid conjugate

2002 ◽  
Vol 16 (11) ◽  
pp. 1426-1428 ◽  
Author(s):  
Alexandre G. Rebuffat ◽  
Andrea R. Nawrocki ◽  
Peter E. Nielsen ◽  
Alessio G. Bernasconi ◽  
Eloy Bernal‐Mendez ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Gene Delivery ◽  
Peptide Nucleic Acid ◽  
Acid Conjugate

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Design and in-silico screening of Peptide Nucleic Acid (PNA) inspired novel pronucleotide scaffolds targeting COVID-19

2020 ◽  
Vol 16 ◽  
Author(s):  
Bichismita Sahu ◽  
Santosh Kumar Behera ◽  
Rudradip Das ◽  
Tanay Dalvi ◽  
Arnab Chowdhury ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
In Silico ◽  
Peptide Nucleic Acid ◽  
Large Set ◽  
Nonstructural Proteins ◽  
In Silico Screening ◽  
Replication Process ◽  
Enveloped Virus ◽  
Treatment Regimens ◽  
Novel Coronavirus

Introduction: The outburst of the novel coronavirus COVID-19, at the end of December 2019 has turned itself into a pandemic taking a heavy toll on human lives. The causal agent being SARS-CoV-2, a member of the long-known Coronaviridae family, is a positive sense single-stranded enveloped virus and quite closely related to SARS-CoV. It has become the need of the hour to understand the pathophysiology of this disease, so that drugs, vaccines, treatment regimens and plausible therapeutic agents can be produced. Methods: In this regard, recent studies uncovered the fact that the viral genome of SARS-CoV-2 encodes nonstructural proteins like RNA dependent RNA polymerase (RdRp) which is an important tool for its transcription and replication process. A large number of nucleic acid based anti-viral drugs are being repurposed for treating COVID-19 targeting RdRp. Few of them are in the advanced stage of clinical trials including Remdesivir. While performing close investigation of the large set of nucleic acid based drugs, we were surprised to find that the synthetic nucleic acid backbone is explored very little or rare. Results: We have designed scaffolds derived from peptide nucleic acid (PNA) and subjected them for in-silico screening systematically. These designed molecules have demonstrated excellent binding towards RdRp. Compound 12 was found to possess similar binding affinity as Remdesivir with comparable pharmacokinetics. However, the in-silico toxicity prediction indicates compound 12 may be a superior molecule which can be explored further due to its excellent safety-profile with LD50 (12,000mg/kg) as opposed to Remdesivir (LD50 =1000mg/kg). Conclusion: Compound 12 falls in the safe category of class 6. Synthetic feasibility, equipotent binding and very low toxicity of this peptide nucleic acid derived compounds can serve as a leading scaffold to design, synthesize and evaluate many of similar compounds for the treatment of COVID-19.

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