scholarly journals Crystal Structure of the Central Coiled-Coil Domain from Human Liprin-β2

Biochemistry ◽  
2011 ◽  
Vol 50 (18) ◽  
pp. 3807-3815 ◽  
Author(s):  
Ryan L. Stafford ◽  
Ming-Yun Tang ◽  
Michael R. Sawaya ◽  
Martin L. Phillips ◽  
James U. Bowie
Keyword(s):  
Crystal Structure ◽  
Coiled Coil ◽  
Coiled Coil Domain

Crystal structure of the coiled‐coil domain of Drosophila TRIM protein Brat

2019 ◽  
Vol 87 (8) ◽  
pp. 706-710 ◽  
Author(s):  
Chunhua Liu ◽  
Zelin Shan ◽  
Jianqiao Diao ◽  
Wenyu Wen ◽  
Wenning Wang
Keyword(s):  
Crystal Structure ◽  
Coiled Coil ◽  
Trim Protein ◽  
Coiled Coil Domain

scholarly journals Crystal Structure of a Coiled-Coil Domain from Human ROCK I

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18080 ◽  
Author(s):  
Daqi Tu ◽  
Yiqun Li ◽  
Hyun Kyu Song ◽  
Angela V. Toms ◽  
Christopher J. Gould ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Coiled Coil ◽  
Coiled Coil Domain

scholarly journals The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif

2017 ◽  
Vol 73 (3) ◽  
pp. 130-137 ◽  
Author(s):  
Shunya Sakurai ◽  
Taisuke Tomita ◽  
Toshiyuki Shimizu ◽  
Umeharu Ohto
Keyword(s):  
Crystal Structure ◽  
Coiled Coil ◽  
Adaptor Protein ◽  
Structural Basis ◽  
Core Sequence ◽  
Coiled Coil Domain ◽  
Flanking Sequences ◽  
Flanking Region ◽  
Membrane Components ◽  
Lir Motif

FYVE and coiled-coil domain-containing protein 1 (FYCO1), a multidomain autophagy adaptor protein, mediates microtubule plus-end-directed autophagosome transport by interacting with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7 and phosphatidylinositol 3-phosphate (PI3P). To establish the structural basis for the recognition of FYCO1 by LC3, the crystal structure of mouse LC3B in complex with the FYCO1 LC3-interacting region (LIR) motif peptide was determined. Structural analysis showed that the flanking sequences N-terminal and C-terminal to the LIR core sequence of FYCO1, as well as the tetrapeptide core sequence, were specifically recognized by LC3B and contributed to the binding. Moreover, comparisons of related structures revealed a conserved mechanism of FYCO1 recognition by different LC3 isoforms among different species.

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