scholarly journals Single Turnover Kinetics of Tryptophan Hydroxylase: Evidence for a New Intermediate in the Reaction of the Aromatic Amino Acid Hydroxylases

Biochemistry ◽  
2010 ◽  
Vol 49 (35) ◽  
pp. 7563-7571 ◽  
Author(s):  
Jorge Alex Pavon ◽  
Bekir Eser ◽  
Michaela T. Huynh ◽  
Paul F. Fitzpatrick
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Tryptophan Hydroxylase ◽  
Single Turnover ◽  
Kinetics Of ◽  
Aromatic Amino Acid Hydroxylases

Assignment of human tryptophan hydroxylase locus to chromosome 11: Gene duplication and translocation in evolution of aromatic amino acid hydroxylases

1987 ◽  
Vol 13 (5) ◽  
pp. 575-580 ◽  
Author(s):  
Fred D. Ledley ◽  
Hernan E. Grenett ◽  
David P. Bartos ◽  
Peter Tuinen ◽  
David H. Ledbetter ◽  
...  
Keyword(s):  
Amino Acid ◽  
Gene Duplication ◽  
Aromatic Amino Acid ◽  
Tryptophan Hydroxylase ◽  
Chromosome 11 ◽  
Aromatic Amino Acid Hydroxylases

scholarly journals A monoclonal antibody to aromatic amino acid hydroxylases. Identification of the epitope

1988 ◽  
Vol 255 (1) ◽  
pp. 193-196 ◽  
Author(s):  
R G H Cotton ◽  
W McAdam ◽  
I Jennings ◽  
F J Morgan
Keyword(s):  
Monoclonal Antibody ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Tryptophan Hydroxylase ◽  
Phenylalanine Hydroxylase ◽  
Amino Acid Residues ◽  
Vertebrate Species ◽  
Wide Range ◽  
Human Phenylalanine Hydroxylase ◽  
Aromatic Amino Acid Hydroxylases

PH8 monoclonal antibody has previously been shown to react with all three aromatic amino acid hydroxylases, being particularly useful for immunohistochemical staining of brain tissue [Haan, Jennings, Cuello, Nakata, Chow, Kushinsky, Brittingham & Cotton (1987) Brain Res. 426, 19-27]. Western-blot analysis of liver extracts showed that PH8 reacted with phenylalanine hydroxylase from a wide range of vertebrate species. The epitope for antibody PH8 has been localized to the human phenylalanine hydroxylase sequence between amino acid residues 139 and 155. This highly conserved region of the aromatic amino acid hydroxylases has 11 out of 17 amino acids identical in phenylalanine hydroxylase, tyrosine hydroxylase and tryptophan hydroxylase.

Tetrahydrobiopterin Binding to Aromatic Amino Acid Hydroxylases. Ligand Recognition and Specificity

2004 ◽  
Vol 47 (24) ◽  
pp. 5962-5971 ◽  
Author(s):  
Knut Teigen ◽  
Khanh K. Dao ◽  
Jeffrey A. McKinney ◽  
Antonius C. F. Gorren ◽  
Bernd Mayer ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Ligand Recognition ◽  
Aromatic Amino Acid Hydroxylases
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