Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis†

Alessandro Pandini; Michael S. Denison; Yujuan Song; Anatoly A. Soshilov; Laura Bonati

doi:10.1021/bi061460t

Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis†

Biochemistry ◽

10.1021/bi061460t ◽

2007 ◽

Vol 46 (3) ◽

pp. 696-708 ◽

Cited By ~ 80

Author(s):

Alessandro Pandini ◽

Michael S. Denison ◽

Yujuan Song ◽

Anatoly A. Soshilov ◽

Laura Bonati

Keyword(s):

Ligand Binding ◽

Homology Modeling ◽

Aryl Hydrocarbon Receptor ◽

Mutational Analysis ◽

Functional Characterization ◽

Binding Domain ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon

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Comparative analysis of interactions between aryl hydrocarbon receptor ligand binding domain with its ligands: a computational study

BMC Structural Biology ◽

10.1186/s12900-018-0095-2 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 6

Author(s):

Kumaraswamy Naidu Chitrala ◽

Xiaoming Yang ◽

Prakash Nagarkatti ◽

Mitzi Nagarkatti

Keyword(s):

Comparative Analysis ◽

Ligand Binding ◽

Aryl Hydrocarbon Receptor ◽

Computational Study ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon

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A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain

Biology ◽

10.3390/biology3040645 ◽

2014 ◽

Vol 3 (4) ◽

pp. 645-669 ◽

Cited By ~ 19

Author(s):

Arden Perkins ◽

Jessica Phillips ◽

Nancy Kerkvliet ◽

Robert Tanguay ◽

Gary Perdew ◽

...

Keyword(s):

Ligand Binding ◽

Aryl Hydrocarbon Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon ◽

Agonist And Antagonist ◽

Optimized Model

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Ligand Displaces Heat Shock Protein 90 from Overlapping Binding Sites within the Aryl Hydrocarbon Receptor Ligand-binding Domain

Journal of Biological Chemistry ◽

10.1074/jbc.m111.246439 ◽

2011 ◽

Vol 286 (40) ◽

pp. 35275-35282 ◽

Cited By ~ 29

Author(s):

Anatoly Soshilov ◽

Michael S. Denison

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Ligand Binding ◽

Aryl Hydrocarbon Receptor ◽

Binding Sites ◽

Heat Shock Protein 90 ◽

Binding Domain ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon

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Expression of the C. elegans aryl hydrocarbon receptor ligand-binding domain

Toxicology ◽

10.1016/j.tox.2008.07.033 ◽

2008 ◽

Vol 253 (1-3) ◽

pp. 25 ◽

Cited By ~ 1

Author(s):

Ahmed Helaly ◽

Tao Jiang ◽

David R. Bell

Keyword(s):

Ligand Binding ◽

Aryl Hydrocarbon Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

C Elegans ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon

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Amino Acid Substitutions in the Aryl Hydrocarbon Receptor Ligand Binding Domain Reveal YH439 As an Atypical AhR Activator

Molecular Pharmacology ◽

10.1124/mol.109.062927 ◽

2010 ◽

Vol 77 (6) ◽

pp. 1037-1046 ◽

Cited By ~ 17

Author(s):

Fiona Whelan ◽

Nan Hao ◽

Sebastian G. B. Furness ◽

Murray L. Whitelaw ◽

Anne Chapman-Smith

Keyword(s):

Amino Acid ◽

Ligand Binding ◽

Aryl Hydrocarbon Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Amino Acid Substitutions ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon

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Characterization of in Vitro Metabolites of the Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]carbazole by Liquid Chromatography-Mass Spectrometry and NMR.

Drug Metabolism and Disposition ◽

10.1124/dmd.31.2.233 ◽

2003 ◽

Vol 31 (2) ◽

pp. 233-241 ◽

Cited By ~ 30

Author(s):

Linda Bergander ◽

Niklas Wahlström ◽

Tomas Alsberg ◽

Jan Bergman ◽

Agneta Rannug ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Aryl Hydrocarbon Receptor ◽

Liquid Chromatography Mass Spectrometry ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon ◽

Chromatography Mass Spectrometry

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Systematic and functional characterization of novel androgen receptor variants arising from alternative splicing in the ligand-binding domain

Oncogene ◽

10.1038/onc.2016.313 ◽

2016 ◽

Vol 36 (10) ◽

pp. 1440-1450 ◽

Cited By ~ 2

Author(s):

T Uo ◽

H Dvinge ◽

C C Sprenger ◽

R K Bradley ◽

P S Nelson ◽

...

Keyword(s):

Androgen Receptor ◽

Alternative Splicing ◽

Ligand Binding ◽

Functional Characterization ◽

Binding Domain ◽

Ligand Binding Domain ◽

Androgen Receptor Variants

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Sensitivity of avian species to the aryl hydrocarbon receptor ligand 6-formylindolo [3,2-b] carbazole (FICZ)

Chemico-Biological Interactions ◽

10.1016/j.cbi.2014.07.009 ◽

2014 ◽

Vol 221 ◽

pp. 61-69 ◽

Cited By ~ 11

Author(s):

Reza Farmahin ◽

Doug Crump ◽

Sean W. Kennedy

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Avian Species ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon

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Functional characterization of aryl hydrocarbon receptor (zfAHR2) localization and degradation in zebrafish (Danio rerio)

Biochemical Pharmacology ◽

10.1016/j.bcp.2003.12.002 ◽

2004 ◽

Vol 67 (7) ◽

pp. 1363-1372 ◽

Cited By ~ 23

Author(s):

Jeannette N. Wentworth ◽

Robert Buzzeo ◽

Richard S. Pollenz

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Danio Rerio ◽

Functional Characterization ◽

Aryl Hydrocarbon

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Suppression of Experimental Autoimmune Encephalomyelitis with Nanoparticles Carrying a Central Nervous System Antigen and a Non-Toxic Aryl Hydrocarbon Receptor Ligand (SC01.004)

Neurology ◽

10.1212/wnl.78.1_meetingabstracts.sc01.004 ◽

2012 ◽

Vol 78 (Meeting Abstracts 1) ◽

pp. SC01.004-SC01.004

Author(s):

A. Yeste ◽

M. Nadeau ◽

E. Burns ◽

H. Weiner ◽

F. Quintana

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Experimental Autoimmune Encephalomyelitis ◽

Aryl Hydrocarbon Receptor ◽

Autoimmune Encephalomyelitis ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon ◽

Experimental Autoimmune

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