Surface Plasmon Resonance and Nuclear Magnetic Resonance Studies of ABAD−Aβ Interaction†

Biochemistry ◽  
2007 ◽  
Vol 46 (7) ◽  
pp. 1724-1731 ◽  
Author(s):  
Yilin Yan ◽  
Yangzhong Liu ◽  
Mirco Sorci ◽  
Georges Belfort ◽  
Joyce W. Lustbader ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Surface Plasmon Resonance ◽  
Magnetic Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Magnetic Resonance Studies ◽  
Nuclear Magnetic

scholarly journals Applied Biophysical Methods in Fragment-Based Drug Discovery

2020 ◽  
Vol 25 (5) ◽  
pp. 471-490 ◽  
Author(s):  
Joe Coyle ◽  
Reto Walser
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Surface Plasmon Resonance ◽  
Drug Discovery ◽  
Magnetic Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Novice User ◽  
Fda Approval ◽  
Thermal Shift ◽  
Fragment Based Drug Discovery

Fragment-based drug discovery (FBDD) has come of age in the last decade with the FDA approval of four fragment-derived drugs. Biophysical methods are at the heart of hit discovery and validation in FBDD campaigns. The three most commonly used methods, thermal shift, surface plasmon resonance, and nuclear magnetic resonance, can be daunting for the novice user. We aim here to provide the nonexpert user of these methods with a summary of problems and challenges that might be faced, but also highlight the potential gains that each method can contribute to an FBDD project. While our view on FBDD is slightly biased toward enabling structure-guided drug discovery, most of the points we address in this review are also valid for non-structure-focused FBDD.

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