scholarly journals Selective Deletion of the NH2-Terminal Variable Region of Cardiac Troponin T in Ischemia Reperfusion by Myofibril-Associated μ-Calpain Cleavage†

Biochemistry ◽  
2006 ◽  
Vol 45 (38) ◽  
pp. 11681-11694 ◽  
Author(s):  
Zhiling Zhang ◽  
Brandon J. Biesiadecki ◽  
Jian-Ping Jin
Keyword(s):  
Cardiac Troponin ◽  
Troponin T ◽  
Ischemia Reperfusion ◽  
Variable Region ◽  
Cardiac Troponin T

scholarly journals Upregulation of Restrictive N-Terminal Truncation of Cardiac Troponin T in Ischemia-Reperfusion Preserves Ventricular Function

2012 ◽  
Vol 102 (3) ◽  
pp. 561a
Author(s):  
Han-Zhong Feng ◽  
Heidi L. Lujan ◽  
Karin Przyklenk ◽  
Stephen E. DiCarlo ◽  
J.-P. Jin
Keyword(s):  
Ventricular Function ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Ischemia Reperfusion ◽  
Cardiac Troponin T

scholarly journals Sensitivity to Perioperative Ischemia/Reperfusion Injury in Male and Female Donor Myocardium

2017 ◽  
pp. 949-957 ◽  
Author(s):  
M. SMETANA ◽  
J. BESIK ◽  
I. NETUKA ◽  
J. MALY ◽  
J. MALUSKOVA ◽  
...  
Keyword(s):  
Cell Death ◽  
Cardiac Troponin ◽  
Caspase 3 ◽  
Troponin T ◽  
Apoptotic Cell ◽  
Ischemia Reperfusion ◽  
Cardiac Troponin T ◽  
Male And Female ◽  
Ventricular Mass ◽  
Apoptosis Markers

Many functions of the cardiovascular apparatus are affected by gender. The aim of our study was find out whether markers of cell death present in the donor myocardium differ in male and female hearts. The study involved 81 patients undergoing heart transplantation from September 2010 to January 2013. Patients were divided into two groups: male allograft (n=49), and female allograft (n=32). Two types of myocardial cell death were analyzed. High-sensitive cardiac troponin T as a necrosis marker and protein bcl-2, caspase 3 and TUNEL as apoptosis markers were measured. We observed a significantly higher level of high-sensitive cardiac troponin T after correcting for predicted ventricular mass in female donors before transplantation as well as in the female allograft group after transplantation throughout the monitored period (P=0.011). There were no differences in apoptosis markers (bcl-2, caspase 3, TUNEL) between male and female hearts before transplantation. Both genders showed a significant increase of TUNEL-positive myocytes one week after transplantation without differences between the groups. Moreover, there were no differences in caspase 3 and bcl-2 expression between the two groups. Our results demonstrated the presence of necrotic and apoptotic cell death in human heart allografts. High-sensitive cardiac troponin T adjusted for predicted ventricular mass as a marker of myocardial necrosis was higher in female donors, and this gender difference was even more pronounced after transplantation.

Cardioprotective Effect of Saffron Extracts against Acute Doxorubicin Toxicity in Isolated Rabbit Hearts Submitted to Ischemia-Reperfusion Injury

2014 ◽  
Vol 69 (11-12) ◽  
pp. 459-470 ◽  
Author(s):  
Nathalie Chahine ◽  
Hassane Makhlouf ◽  
Laurent Duca ◽  
Laurent Martiny ◽  
Ramez Chahine
Keyword(s):  
P38 Mapk ◽  
Cardiac Troponin ◽  
Ischemia Reperfusion Injury ◽  
Troponin T ◽  
Mapk Pathway ◽  
Ischemia Reperfusion ◽  
Myocardial Damage ◽  
Crocus Sativus ◽  
Cardiac Troponin T ◽  
Protective Effects

Abstract Doxorubicin (DOX) is an anthracycline antibiotic routinely used as a chemotherapeutic agent for the treatment of solid tumours. However, DOX possesses an acute and cumulative cardiotoxicity due to free radical production. The present study was designed to investigate the possible protective effects of saffron (Crocus sativus) extracts against DOX-induced acute cardiotoxicity in isolated rabbit hearts submitted to 30 min global ischemia followed by 40 min reperfusion. DOX was delivered during reperfusion, without or with saffron given 5 min before ischemia or at reperfusion. Cardiodynamic, biochemical, and histopathological parameters were determined. In addition, to determine the expression of the AKT/mTOR/4EBP1 pathway, the levels of p38 MAPK and cardiac troponin T in heart homogenates were visualized by Western blotting. DOX administration during 40 min of reperfusion increased ischemic tissue damage, but did not act synergistically. Administration of saffron extracts during the first minutes of reperfusion significantly reduced oxidative myocardial damage, but was less effective when given before ischemia. Subsequent Western blot analysis revealed that saffron administration preserved cardiac troponin T proteins, inhibited the p38 MAPK pathway, and activated the AKT/mTOR/4EBP1 pathway in reperfusion- and DOX-treated rabbit hearts. In conclusion, saffron extracts, acting through antioxidant and antiapoptotic mechanisms, exhibited a protective effect against DOX-induced cardiotoxicity under ischemic condition.

Cardiac Troponin I and cardiac Troponin T increases in pigs during ischemia-reperfusion damage

2000 ◽  
Vol 52 (2) ◽  
pp. 157-159 ◽  
Author(s):  
T. Bertsch ◽  
C. Janke ◽  
C. Denz ◽  
M. Weiss ◽  
T. Luiz ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Ischemia Reperfusion ◽  
Cardiac Troponin I ◽  
Cardiac Troponin T ◽  
Reperfusion Damage

1461-P: Cardiac Troponin T and Troponin I and Incident Diabetes in the General Population: Generation Scotland Scottish Family Health Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1461-P
Author(s):  
PAUL WELSH ◽  
DAVID PREISS ◽  
ARCHIE CAMPBELL ◽  
DAVID J. PORTEOUS ◽  
NICHOLAS L. MILLS ◽  
...  
Keyword(s):  
General Population ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Family Health ◽  
Incident Diabetes ◽  
Health Study ◽  
Cardiac Troponin T ◽  
Generation Scotland
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