scholarly journals Crystal Structure of a Luteoviral RNA Pseudoknot and Model for a Minimal Ribosomal Frameshifting Motif†,‡

Biochemistry ◽  
2005 ◽  
Vol 44 (34) ◽  
pp. 11315-11322 ◽  
Author(s):  
Pradeep S. Pallan ◽  
William S. Marshall ◽  
Joel Harp ◽  
Frederic C. Jewett ◽  
Zdzislaw Wawrzak ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ribosomal Frameshifting ◽  
Rna Pseudoknot

scholarly journals Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot

RNA ◽  
2021 ◽  
pp. rna.078825.121
Author(s):  
Christopher P Jones ◽  
Adrian R Ferre-D'Amare
Keyword(s):  
Crystal Structure ◽  
Severe Acute Respiratory Syndrome ◽  
Small Molecule ◽  
Viral Protein ◽  
Open Reading Frame ◽  
Ribosomal Frameshifting ◽  
Reading Frame ◽  
X Ray ◽  
Rna Pseudoknot ◽  
Small Molecule Therapeutics

SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome, and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics.

scholarly journals Small synthetic molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshifting

2018 ◽  
Vol 46 (16) ◽  
pp. 8079-8089 ◽  
Author(s):  
Saki Matsumoto ◽  
Neva Caliskan ◽  
Marina V Rodnina ◽  
Asako Murata ◽  
Kazuhiko Nakatani
Keyword(s):  
Ribosomal Frameshifting ◽  
Rna Pseudoknot ◽  
Synthetic Molecule

scholarly journals Characterization of an efficient coronavirus ribosomal frameshifting signal: Requirement for an RNA pseudoknot

Cell ◽  
1989 ◽  
Vol 57 (4) ◽  
pp. 537-547 ◽  
Author(s):  
Ian Brierley ◽  
Paul Digard ◽  
Stephen C. Inglis
Keyword(s):  
Ribosomal Frameshifting ◽  
Rna Pseudoknot

scholarly journals A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting

Nature ◽  
2006 ◽  
Vol 441 (7090) ◽  
pp. 244-247 ◽  
Author(s):  
Olivier Namy ◽  
Stephen J. Moran ◽  
David I. Stuart ◽  
Robert J. C. Gilbert ◽  
Ian Brierley
Keyword(s):  
Ribosomal Frameshifting ◽  
Mechanical Explanation ◽  
Rna Pseudoknot

scholarly journals An RNA pseudoknot stimulates HTLV-1 pro-pol programmed −1 ribosomal frameshifting

RNA ◽  
2020 ◽  
Vol 26 (4) ◽  
pp. 512-528
Author(s):  
Eliza Thulson ◽  
Erik W. Hartwick ◽  
Andrew Cooper-Sansone ◽  
Marcus A.C. Williams ◽  
Mary E. Soliman ◽  
...  
Keyword(s):  
Ribosomal Frameshifting ◽  
Rna Pseudoknot

scholarly journals Stem-loop structures can effectively substitute for an RNA pseudoknot in -1 ribosomal frameshifting

2011 ◽  
Vol 39 (20) ◽  
pp. 8952-8959 ◽  
Author(s):  
C.-H. Yu ◽  
M. H. Noteborn ◽  
C. W. A. Pleij ◽  
R. C. L. Olsthoorn
Keyword(s):  
Stem Loop ◽  
Ribosomal Frameshifting ◽  
Rna Pseudoknot
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