Interplay between Human High Mobility Group Protein 1 and Replication Protein A on Psoralen-Cross-linked DNA†

Biochemistry ◽  
2005 ◽  
Vol 44 (11) ◽  
pp. 4188-4195 ◽  
Author(s):  
Madhava C. Reddy ◽  
Jesper Christensen ◽  
Karen M. Vasquez
Keyword(s):  
Protein A ◽  
High Mobility ◽  
Replication Protein A ◽  
Replication Protein ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein

Role of High-mobility Group Protein A Isoforms and Their Clinicopathologic Significance in Primary Retinoblastoma

2017 ◽  
Vol 25 (4) ◽  
pp. 244-250 ◽  
Author(s):  
Mithalesh K. Singh ◽  
Lata Singh ◽  
Seema Sen ◽  
Neelam Pushker ◽  
Anjana Sharma ◽  
...  
Keyword(s):  
Protein A ◽  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein

scholarly journals Detection of monoclonal antibody to high-mobility-group protein 17 from chick oviduct

1982 ◽  
Vol 203 (2) ◽  
pp. 471-476 ◽  
Author(s):  
C S Teng ◽  
C T Teng ◽  
T S Chan
Keyword(s):  
Solid Phase ◽  
Protein A ◽  
High Mobility ◽  
High Mobility Group ◽  
Chromosomal Protein ◽  
Hmg Proteins ◽  
High Mobility Group Protein ◽  
Group Protein ◽  
Solid Phase Radioimmunoassay ◽  
Hmg Protein

Total chromosomal HMG (high-mobility-group) proteins have been isolated from oestrogen-stimulated chick oviduct. The antibodies against these proteins were induced in mice and subsequently their spleen cells were fused with myeloma cells to form hybridomas. A highly purified HMG protein, 17, was used to select for the hybridomas that produce antibody against HMG protein 17. The hybridomas were cultured and injected into mice to produce ascites. The antibody against HMG protein 17 in the IgG (immunoglobulin G) fraction of the ascites fluid was obtained by Protein A-Sepharose column chromatography. We have devised a solid-phase radioimmunoassay and enzyme-linked serological assay for the detection and characterization of this antibody directed against HMG protein 17. This anti-(HMG protein 17) IgG interacted only with HMG protein 17, but not with other chromosomal proteins, e.g. histone H1, ‘95K protein’ (a chick oviduct-specific chromosomal protein) and HMG proteins 1, 2 and 14. The monospecific nature of this anti-(HMG protein 17) IgG fraction is confirmed.

scholarly journals HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 822
Author(s):  
Keiichi Matsubara ◽  
Yuko Matsubara ◽  
Yuka Uchikura ◽  
Katsuko Takagi ◽  
Akiko Yano ◽  
...  
Keyword(s):  
Protein A ◽  
High Mobility ◽  
Extravillous Trophoblast ◽  
High Mobility Group Protein ◽  
Successful Pregnancy ◽  
Group Protein ◽  
Serious Disease ◽  
Proliferation And Invasion ◽  
Extravillous Trophoblasts ◽  
Fertilized Egg

Preeclampsia (PE) is a serious disease that can be fatal for the mother and fetus. The two-stage theory has been proposed as its cause, with the first stage comprising poor placentation associated with the failure of fertilized egg implantation. Successful implantation and placentation require maternal immunotolerance of the fertilized egg as a semi-allograft and appropriate extravillous trophoblast (EVT) invasion of the decidua and myometrium. The disturbance of EVT invasion during implantation in PE results in impaired spiral artery remodeling. PE is thought to be caused by hypoxia during remodeling failure–derived poor placentation, which results in chronic inflammation. High-mobility group protein A (HMGA) is involved in the growth and invasion of cancer cells and likely in the growth and invasion of trophoblasts. Its mechanism of action is associated with immunotolerance. Thus, HMGA is thought to play a pivotal role in successful pregnancy, and its dysfunction may be related to the pathogenesis of PE. The evaluation of HMGA function and its changes in PE might confirm that it is a reliable biomarker of PE and provide prospects for PE treatment through the induction of EVT proliferation and invasion during the implantation.

scholarly journals Characterization of high mobility group protein levels during spermatogenesis in the rat.

1984 ◽  
Vol 259 (14) ◽  
pp. 8840-8846
Author(s):  
L R Bucci ◽  
W A Brock ◽  
I L Goldknopf ◽  
M L Meistrich
Keyword(s):  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Protein Levels ◽  
Group Protein
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