Ligand Migration and Protein Fluctuations in Myoglobin Mutant L29W†,‡

Biochemistry ◽  
2005 ◽  
Vol 44 (13) ◽  
pp. 5095-5105 ◽  
Author(s):  
Karin Nienhaus ◽  
Andreas Ostermann ◽  
G. Ulrich Nienhaus ◽  
Fritz G. Parak ◽  
Marius Schmidt
Keyword(s):  
Ligand Migration ◽  
Protein Fluctuations

scholarly journals Front Cover: Ligand Migration from Cluster to Support: A Crucial Factor for Catalysis by Thiolate‐protected Gold Clusters (ChemCatChem 23/2018)

ChemCatChem ◽  
2018 ◽  
Vol 10 (23) ◽  
pp. 5337-5337 ◽  
Author(s):  
Bei Zhang ◽  
Annelies Sels ◽  
Giovanni Salassa ◽  
Stephan Pollitt ◽  
Vera Truttmann ◽  
...  
Keyword(s):  
Gold Clusters ◽  
Front Cover ◽  
Ligand Migration

scholarly journals Ligand Migration from Cluster to Support: A Crucial Factor for Catalysis by Thiolate‐protected Gold Clusters

ChemCatChem ◽  
2018 ◽  
Vol 10 (23) ◽  
pp. 5341-5341
Author(s):  
Bei Zhang ◽  
Annelies Sels ◽  
Giovanni Salassa ◽  
Stephan Pollitt ◽  
Vera Truttmann ◽  
...  
Keyword(s):  
Gold Clusters ◽  
Ligand Migration

scholarly journals Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis

2018 ◽  
Author(s):  
Cerys S Manning ◽  
Veronica Biga ◽  
James Boyd ◽  
Jochen Kursawe ◽  
Bodvar Ymisson ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Fate ◽  
Live Imaging ◽  
Protein Quantification ◽  
Expression Change ◽  
Dynamic View ◽  
Transient Period ◽  
Gene Expression Dynamics ◽  
Transcription Factor Expression ◽  
Protein Fluctuations

AbstractDuring embryogenesis cells make fate decisions within complex tissue environments. The levels and dynamics of transcription factor expression regulate these decisions. Here we use single cell live imaging of an endogenous HES5 reporter and absolute protein quantification to gain a dynamic view of neurogenesis in the embryonic mammalian spinal cord. We report that dividing neural progenitors show both aperiodic and periodic HES5 protein fluctuations. Mathematical modelling suggests that in progenitor cells the HES5 oscillator operates close to its bifurcation boundary where stochastic conversions between dynamics are possible. HES5 expression becomes more frequently periodic as cells transition to differentiation which, coupled with an overall decline in HES5 expression, creates a transient period of oscillations with higher fold expression change. This increases the decoding capacity of HES5 oscillations and correlates with interneuron versus motor neuron cell fate. Thus, HES5 undergoes complex changes in gene expression dynamics as cells differentiate.

Kinetics and computational studies of ligand migration in nitrophorin 7 and its Δ1–3 mutant

2013 ◽  
Vol 1834 (9) ◽  
pp. 1711-1721 ◽  
Author(s):  
Ana Oliveira ◽  
Alessandro Allegri ◽  
Axel Bidon-Chanal ◽  
Markus Knipp ◽  
Adrian E. Roitberg ◽  
...  
Keyword(s):  
Computational Studies ◽  
Ligand Migration

The effect of protein internal cavities on ligand migration and binding in myoglobin

Micron ◽  
2004 ◽  
Vol 35 (1-2) ◽  
pp. 67-69 ◽  
Author(s):  
Karin Nienhaus ◽  
Gerd U Nienhaus
Keyword(s):  
Internal Cavities ◽  
Ligand Migration

scholarly journals Neutron Scattering Reveals Protein Fluctuations in GPCR Activation

2016 ◽  
Vol 110 (3) ◽  
pp. 228a-229a
Author(s):  
Suchithranga M.D.C. Perera ◽  
Utsab Shrestha ◽  
Debsindhu Bhowmik ◽  
Udeep Chawla ◽  
Andrey V. Struts ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Gpcr Activation ◽  
Protein Fluctuations
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