Identification of Novel in Vivo Phosphorylation Sites in High Mobility Group N1 Protein from the MCF-7 Human Breast Cancer Cells

Biochemistry ◽  
2004 ◽  
Vol 43 (20) ◽  
pp. 6322-6329 ◽  
Author(s):  
Yan Zou ◽  
Xinzhao Jiang ◽  
Yinsheng Wang
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
High Mobility ◽  
Phosphorylation Sites ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

scholarly journals Constitutive Expression of the Steroid Sulfatase Gene Supports the Growth of MCF-7 Human Breast Cancer Cells in Vitroand in Vivo*

Endocrinology ◽  
2001 ◽  
Vol 142 (4) ◽  
pp. 1497-1505 ◽  
Author(s):  
Mattie R. James ◽  
Todd C. Skaar ◽  
Richard Y. Lee ◽  
Alexander MacPherson ◽  
James A. Zwiebel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Constitutive Expression ◽  
Steroid Sulfatase ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

scholarly journals Protoporphyrin IX-loaded laminarin nanoparticles for anticancer treatment, their cellular behavior, ROS detection, and animal studies

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yueming Yu ◽  
Bingjie Wang ◽  
Chunjing Guo ◽  
Feng Zhao ◽  
Daquan Chen
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Protoporphyrin Ix ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Abstract Laminarin conjugate-based nano-scaled particles were in this study proposed as a delivery system for protoporphyrin IX (Pp IX) in photodynamic therapy (PDT) of human breast cancer cells (MCF-7). Hematin-Laminarin-Dithiodipropionic Acid-MGK, named as HLDM, was an amphiphilic carrier material with dual pH/redox sensitive that could be used to load hydrophobic drug to improve their solubility and enhance biocompatibility. Therefore, we combined photosensitizer (Pp IX) with HLDM to fabricate a novel nano-micelles, herein called Pp IX-loaded HLDM micelles. The Pp IX-loaded HLDM micelles were 149.3 ± 35 nm sized in neutral water. Phototoxicity, in vitro PDT effect, and dual sensibility to pH and redox microenvironment of Pp IX-loaded HLDM micelles were examined at different concentrations by using MCF-7 human breast cancer cells. The experiments on phototoxicity and reactive oxygen species (ROS) production proved that the micelles could produce PDT to kill the cancer cells with a certain wavelength light. The apoptosis experiment indicated that the micelles could cause nuclear damage. In vivo PDT effect of the micelles was studied by constructing the tumor-bearing nude mouse model of MCF-7 cells. In vivo studies showed that the Pp IX-loaded HLDM micelles could induce remarkable anti-tumor effect. A promising laminarin-based nanomedicine platform acts as a new drug delivery system to enhance the uptake, accumulation, and PDT efficacy of Pp IX in vitro and in vivo.

scholarly journals High-mobility group A1a protein regulates Ras/ERK signaling in MCF-7 human breast cancer cells

Oncogene ◽  
2004 ◽  
Vol 23 (3) ◽  
pp. 777-785 ◽  
Author(s):  
Nathan R Treff ◽  
Derek Pouchnik ◽  
Gregory A Dement ◽  
Rachel L Britt ◽  
Raymond Reeves
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
High Mobility ◽  
High Mobility Group ◽  
Erk Signaling ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Clomiphene Analogs with Activity In Vitro and In Vivo against Human Breast Cancer Cells

1998 ◽  
Vol 55 (6) ◽  
pp. 841-851 ◽  
Author(s):  
R.Jeffrey Baumann ◽  
Tammy L. Bush ◽  
Doreen E. Cross-Doersen ◽  
Elizabeth A. Cashman ◽  
Paul S. Wright ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast
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