pH Dependence of Heme Iron Coordination, Hydrogen Peroxide Reactivity, and Cyanide Binding in CytochromecPeroxidase(H52K)†

Biochemistry ◽  
2004 ◽  
Vol 43 (17) ◽  
pp. 5065-5072 ◽  
Author(s):  
Miriam C. Foshay ◽  
Lidia B. Vitello ◽  
James E. Erman
Keyword(s):  
Hydrogen Peroxide ◽  
Ph Dependence ◽  
Heme Iron ◽  
Cyanide Binding ◽  
Iron Coordination

scholarly journals Monitoring the heme iron state in horseradish peroxidase to detect ultratrace amounts of hydrogen peroxide in alcohols

RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 9901-9910
Author(s):  
Raheleh Ravanfar ◽  
Alireza Abbaspourrad
Keyword(s):  
Hydrogen Peroxide ◽  
Horseradish Peroxidase ◽  
Oxidative Damage ◽  
Heme Iron ◽  
Aqueous Systems ◽  
Iron State ◽  
Low Concentrations

Despite the importance of hydrogen peroxide (H2O2) in initiating oxidative damage and its connection to various diseases, the detection of low concentrations of H2O2 (<10 μM) is still limited using current methods, particularly in non-aqueous systems.

The heme iron coordination of unfolded ferric and ferrous cytochrome c in neutral and acidic urea solutions. Spectroscopic and electrochemical studies

2004 ◽  
Vol 1703 (1) ◽  
pp. 31-41 ◽  
Author(s):  
Milan Fedurco ◽  
Jan Augustynski ◽  
Chiara Indiani ◽  
Giulietta Smulevich ◽  
Marián Antalík ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Heme Iron ◽  
Electrochemical Studies ◽  
Iron Coordination

scholarly journals A bottom up approach towards artificial oxygenases by combining iron coordination complexes and peptides

2017 ◽  
Vol 8 (5) ◽  
pp. 3660-3667 ◽  
Author(s):  
Olaf Cussó ◽  
Michael W. Giuliano ◽  
Xavi Ribas ◽  
Scott J. Miller ◽  
Miquel Costas
Keyword(s):  
Hydrogen Peroxide ◽  
Coordination Complexes ◽  
Asymmetric Epoxidation ◽  
Coordination Complex ◽  
High Yield ◽  
Aqueous Hydrogen Peroxide ◽  
Bottom Up ◽  
Iron Coordination

The combination of peptides and a chiral iron coordination complex catalyzes high yield highly asymmetric epoxidation with aqueous hydrogen peroxide.

ortho-Hydroxylation of benzoic acids with hydrogen peroxide at a non-heme iron center

2005 ◽  
pp. 5301 ◽  
Author(s):  
Sonia Taktak ◽  
Margaret Flook ◽  
Bruce M. Foxman ◽  
Lawrence Que, Jr. ◽  
Elena V. Rybak-Akimova
Keyword(s):  
Hydrogen Peroxide ◽  
Heme Iron ◽  
Benzoic Acids ◽  
Non Heme Iron ◽  
Iron Center

scholarly journals The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1

2011 ◽  
Vol 193 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Jeffrey P. Jones ◽  
Carolyn A. Joswig-Jones ◽  
Michelle Hebner ◽  
Yuzhuo Chu ◽  
Dennis R. Koop
Keyword(s):  
Cytochrome P450 ◽  
Heme Iron ◽  
Cytochrome P450 2E1 ◽  
Iron Coordination ◽  
Substrate Affinities

The reduction of I2 by H2O2 in aqueous solution

2001 ◽  
Vol 79 (3) ◽  
pp. 304-311 ◽  
Author(s):  
J M Ball ◽  
J B Hnatiw
Keyword(s):  
Aqueous Solution ◽  
Hydrogen Peroxide ◽  
Nuclear Reactor ◽  
Ph Dependence ◽  
Radiolysis Product ◽  
Molecular Iodine ◽  
Water Radiolysis ◽  
Reactor Accident ◽  
Rate Law ◽  
Accident Conditions

The reduction of I2 by hydrogen peroxide, a primary water radiolysis product, has been identified as a key reaction that would influence iodine volatility in nuclear reactor accident conditions (1–3). Although there have been a number of studies of the reduction of I2, there exists a great degree of controversy regarding the intermediates involved, the effect of buffers, and the general rate law (1–9). Because the rates and the mechanism of this reaction are important in predicting the pH dependence of iodine behaviour in reactor containment building after a postulated reactor accident, we have undertaken a kinetic study of I2 reduction by H2O2 in aqueous solution over a pH range of 6–9. The experiments were performed using stopped-flow instrumentation and monitoring the decay of I–3 spectrophotometrically. The effects of buffer catalysis have been examined by comparison of kinetic data obtained in sodium barbital (5,5-diethylbarbituric acid), disodium citrate, and disodium hydrogen phosphate buffers. The effect of buffers, combined with the complex acid dependence of the rate law, explains many of the discrepancies reported in earlier literature.Key words: hydrogen peroxide, molecular iodine, kinetics, iodine volatility.

Nitroalkanes as Reductive Substrates for Flavoprotein Oxidases

1972 ◽  
Vol 27 (9) ◽  
pp. 1052-1053 ◽  
Author(s):  
David J. T. Porter ◽  
Judith G. Voet ◽  
Harold J. Bright
Keyword(s):  
Hydrogen Peroxide ◽  
Amino Acid ◽  
Glucose Oxidase ◽  
Ph Dependence ◽  
Kinetic Mechanism ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Kinetics Of ◽  
Oxidase Reaction ◽  
Detailed Kinetic Mechanism

Nitroalkanes have been found to be general reductive substrates for D-amino acid oxidase, glucose oxidase and L-amino acid oxidase. These enzymes show different specificities for the structure of the nitroalkane substrate.The stoichiometry of the D-amino acid oxidase reaction is straightforward, consisting of the production of one mole each of aldehyde, nitrite and hydrogen peroxide for each mole of nitroalkane and oxygen consumed. The stoichiometry of the glucose oxidase reaction is more complex in that less than one mole of hydrogen peroxide and nitrite is produced and nitrate and traces of 1-dinitroalkane are formed.The kinetics of nitroalkane oxidation show that the nitroalkane anion is much more reactive in reducing the flavin than is the neutral substrate. The pH dependence of flavin reduction strongly suggests that proton abstraction is a necessary event in catalysis. A detailed kinetic mechanism is presented for the oxidation of nitroethane by glucose.It has been possible to trap a form of modified flavin in the reaction of D-amino acid oxidase with nitromethane from which oxidized FAD can be regenerated in aqueous solution in the presence of oxygen.

Photochemical redox reactions at the zinc oxide-water interface in additive-free systems

1971 ◽  
Vol 24 (6) ◽  
pp. 1193 ◽  
Author(s):  
DR Dixon ◽  
TW Healy
Keyword(s):  
Hydrogen Peroxide ◽  
Redox Reactions ◽  
Heterogeneous Reaction ◽  
Ph Dependence ◽  
H2o2 Production ◽  
Water Interface ◽  
General Reaction ◽  
Interstitial Zinc ◽  
Different Gases ◽  
Hydrolysis Of

When aqueous ZnO suspensions, saturated with oxygen, are irradiated with u.v. light, hydrogen peroxide is formed and a decrease in pH is observed. The effects of different gases (O2, N2, and N2O) on the course of this heterogeneous reaction and also the pH dependence of the reaction have been examined. On the basis of the results obtained, the mechanism which had been previously suggested was modified to allow for the hydrolysis of the zinc(II) ions removed from the crystal lattice during irradiation. A general reaction mechanism proposed to account for H2O2 production in systems with various additives present is extended to additive-free systems where interstitial zinc (Zn1+) is the effective reductant.

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