Pivotal Role of Gly 121 in Dihydrofolate Reductase fromEscherichia coli:  The Altered Structure of a Mutant Enzyme May Form the Basis of Its Diminished Catalytic Performance†

Biochemistry ◽  
2004 ◽  
Vol 43 (14) ◽  
pp. 4119-4127 ◽  
Author(s):  
Richard S. Swanwick ◽  
Paul J. Shrimpton ◽  
Rudolf K. Allemann
Keyword(s):  
Dihydrofolate Reductase ◽  
Catalytic Performance ◽  
Pivotal Role ◽  
Mutant Enzyme ◽  
Fromescherichia Coli

scholarly journals Electric Field Measurements Reveal the Pivotal Role of Cofactor–Substrate Interaction in Dihydrofolate Reductase Catalysis

ACS Catalysis ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 7907-7914
Author(s):  
Aduragbemi S. Adesina ◽  
Katarzyna Świderek ◽  
Louis Y. P. Luk ◽  
Vicent Moliner ◽  
Rudolf K. Allemann
Keyword(s):  
Electric Field ◽  
Dihydrofolate Reductase ◽  
Field Measurements ◽  
Pivotal Role ◽  
Substrate Interaction ◽  
Electric Field Measurements

scholarly journals Pivotal role of dihydrofolate reductase knockdown in the anticancer activity of 2-hydroxyoleic acid

2009 ◽  
Vol 106 (33) ◽  
pp. 13754-13758 ◽  
Author(s):  
V. Llado ◽  
S. Teres ◽  
M. Higuera ◽  
R. Alvarez ◽  
M. A. Noguera-Salva ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Dihydrofolate Reductase ◽  
Pivotal Role

Positive Role of Synthesis Method and Hard Template on the Catalytic Performance of SAPO-34 in Methanol to Olefin Reaction.

2020 ◽  
Vol 23 ◽  
Author(s):  
Sajjad Rimaz ◽  
Reza Katal
Keyword(s):  
Particle Size ◽  
Synthesis Method ◽  
Catalytic Performance ◽  
Hard Template ◽  
Structure Directing Agent ◽  
Positive Role ◽  
Methanol To Olefin ◽  
Dg Method ◽  
Synthesis Procedure

: In the present study, SAPO-34 particles were synthesized using hydrothermal (HT) and dry gel (DG) conversion methods in the presence of diethyl amine (DEA) as an organic structure directing agent (SDA). Carbon nanotubes (CNT) were used as hard template in the synthesis procedure to introduce transport pores into the structures of the synthesized samples. The synthesized samples were characterized with different methods to reveal effects of synthesis method and using hard template on their structure and catalytic performance in methanol to olefin reaction (MTO). DG conversion method results in smaller particle size in comparison with hydrothermal method, resulting in enhancing catalytic performance. On the other side, using CNT in the synthesis procedure with DG method results in more reduction in particle size and formation of hierarchical structure which drastically improves catalytic performance.

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