Functional Consequences of N- or C-Terminal Deletions of the δ Subunit of Chloroplast ATP Synthase†

Biochemistry ◽  
2004 ◽  
Vol 43 (8) ◽  
pp. 2272-2278 ◽  
Author(s):  
Zhang-Lin Ni ◽  
Xiao-Bing Shi ◽  
Jia-Mian Wei
Keyword(s):  
Atp Synthase ◽  
Chloroplast Atp Synthase ◽  
Functional Consequences

scholarly journals Two genes, atpC1 and atpC2, for the γ subunit of Arabidopsis thaliana chloroplast ATP synthase

1991 ◽  
Vol 266 (12) ◽  
pp. 7333-7338
Author(s):  
N Inohara ◽  
A Iwamoto ◽  
Y Moriyama ◽  
S Shimomura ◽  
M Maeda ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Atp Synthase ◽  
Chloroplast Atp Synthase ◽  
Γ Subunit

Import and processing of the precursor of the delta subunit of tobacco chloroplast ATP synthase

1992 ◽  
Vol 20 (3) ◽  
pp. 549-554 ◽  
Author(s):  
J. A. Napier ◽  
K. H. Larsson ◽  
F. Madue�o ◽  
J. C. Gray
Keyword(s):  
Atp Synthase ◽  
Chloroplast Atp Synthase ◽  
Tobacco Chloroplast ◽  
Delta Subunit

scholarly journals Case Report: Identification of a Novel Variant (m.8909T>C) of Human Mitochondrial ATP6 Gene and Its Functional Consequences on Yeast ATP Synthase

Life ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 215
Author(s):  
Qiuju Ding ◽  
Róża Kucharczyk ◽  
Weiwei Zhao ◽  
Alain Dautant ◽  
Shutian Xu ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Atp Synthase ◽  
Atp Synthesis ◽  
Single Individual ◽  
Loss Of Function ◽  
Mtdna Mutations ◽  
Atp6 Gene ◽  
Novel Variant ◽  
Functional Consequences ◽  
Mtdna Variants

With the advent of next generation sequencing, the list of mitochondrial DNA (mtDNA) mutations identified in patients rapidly and continuously expands. They are frequently found in a limited number of cases, sometimes a single individual (as with the case herein reported) and in heterogeneous genetic backgrounds (heteroplasmy), which makes it difficult to conclude about their pathogenicity and functional consequences. As an organism amenable to mitochondrial DNA manipulation, able to survive by fermentation to loss-of-function mtDNA mutations, and where heteroplasmy is unstable, Saccharomyces cerevisiae is an excellent model for investigating novel human mtDNA variants, in isolation and in a controlled genetic context. We herein report the identification of a novel variant in mitochondrial ATP6 gene, m.8909T>C. It was found in combination with the well-known pathogenic m.3243A>G mutation in mt-tRNALeu. We show that an equivalent of the m.8909T>C mutation compromises yeast adenosine tri-phosphate (ATP) synthase assembly/stability and reduces the rate of mitochondrial ATP synthesis by 20–30% compared to wild type yeast. Other previously reported ATP6 mutations with a well-established pathogenicity (like m.8993T>C and m.9176T>C) were shown to have similar effects on yeast ATP synthase. It can be inferred that alone the m.8909T>C variant has the potential to compromise human health.

scholarly journals Chloroplast ATP synthase is reduced by both f-type and m-type thioredoxins

2020 ◽  
Vol 1861 (11) ◽  
pp. 148261 ◽  
Author(s):  
Takatoshi Sekiguchi ◽  
Keisuke Yoshida ◽  
Yuki Okegawa ◽  
Ken Motohashi ◽  
Ken-ichi Wakabayashi ◽  
...  
Keyword(s):  
Atp Synthase ◽  
Chloroplast Atp Synthase
Sign in / Sign up

Export Citation Format

Share Document