Major Kinetic Traps for the Oxidative Folding of Leech Carboxypeptidase Inhibitor†

Biochemistry ◽  
2003 ◽  
Vol 42 (22) ◽  
pp. 6754-6761 ◽  
Author(s):  
Silvia Salamanca ◽  
Li ◽  
Josep Vendrell ◽  
Francesc X. Aviles ◽  
Jui-Yoa Chang
Keyword(s):  
Oxidative Folding ◽  
Carboxypeptidase Inhibitor ◽  
Kinetic Traps

scholarly journals Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI)

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Sebastián A. Esperante ◽  
Giovanni Covaleda ◽  
Sebastián A. Trejo ◽  
Sílvia Bronsoms ◽  
Francesc X. Aviles ◽  
...  
Keyword(s):  
Folding Pathway ◽  
Oxidative Folding ◽  
High Affinity ◽  
Carboxypeptidase Inhibitor

scholarly journals NMR Structural Characterization and Computational Predictions of the Major Intermediate in Oxidative Folding of Leech Carboxypeptidase Inhibitor

Structure ◽  
2005 ◽  
Vol 13 (8) ◽  
pp. 1193-1202 ◽  
Author(s):  
Joan L. Arolas ◽  
Loyola D’Silva ◽  
Grzegorz M. Popowicz ◽  
Francesc X. Aviles ◽  
Tad A. Holak ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Oxidative Folding ◽  
Carboxypeptidase Inhibitor ◽  
Computational Predictions

Study of a Major Intermediate in the Oxidative Folding of Leech Carboxypeptidase Inhibitor: Contribution of the Fourth Disulfide Bond

2005 ◽  
Vol 352 (4) ◽  
pp. 961-975 ◽  
Author(s):  
Joan L. Arolas ◽  
Grzegorz M. Popowicz ◽  
Sílvia Bronsoms ◽  
Francesc X. Aviles ◽  
Robert Huber ◽  
...  
Keyword(s):  
Disulfide Bond ◽  
Oxidative Folding ◽  
Carboxypeptidase Inhibitor

Pathway Complexity in the Stacking of Imine-linked Macrocycles Related to Two-Dimensional Covalent Organic Frameworks

2019 ◽  
Author(s):  
Shiwei Wang ◽  
Anton Chavez ◽  
Simil Thomas ◽  
Hong Li ◽  
Nathan C. Flanders ◽  
...  
Keyword(s):  
Temperature Dependence ◽  
Structural Similarity ◽  
Discrete Models ◽  
Side Chains ◽  
Two Dimensional ◽  
Assembly Process ◽  
Covalent Organic Frameworks ◽  
Electron Systems ◽  
Monomer Structure ◽  
Kinetic Traps

This work reports on the assembly of imine-linked macrocycles that serve as models of two-dimensional covalent organic frameworks (2D COFs). Interlayer interactions play an important role in the formation of 2D COFs, yet the effect of monomer structure on COF formation, crystallinity, and susceptibility to exfoliation are not well understood. For example, monomers with both electron-rich and electron-poor π-electron systems have been proposed to strengthen interlayer inter-actions and improve crystallinity. Here we probe these effects by studying the stacking behavior of imine-linked macrocycles that represent discrete models of 2D COFs. <div><br></div><div>Specifically, macrocycles based on terephthaldehyde (PDA) or 2,5-dimethoxyterephthaldehyde (DMPDA) stack upon cooling molecularly dissolved solutions. Both macrocycles assemble cooperatively with similar ΔHe values of -97 kJ/mol and -101 kJ/mol, respectively, although the DMPDA macrocycle assembly process showed a more straightforward temperature dependence. Circular dichroism spectroscopy performed on macrocycles bearing chiral side chains revealed a helix reversion process for the PDA macrocycles that was not observed for the DMPDA macrocycles. <br></div><div><br></div><div>Given the structural similarity of these monomers, these findings demonstrate that the stacking processes associated with nanotubes derived from these macrocycles, as well as for the corresponding COFs, are complex and susceptible to kinetic traps, casting doubt on the relevance of thermodynamic arguments for improving materials quality. <br></div>

Oxidative Folding of the Cystine Knot Motif in Cyclotide Proteins

2005 ◽  
Vol 12 (2) ◽  
pp. 147-152 ◽  
Author(s):  
David Craik ◽  
Norelle Daly
Keyword(s):  
Oxidative Folding ◽  
Cystine Knot

Identification and characterization of a wolfberry carboxypeptidase inhibitor from Lycium barbarum

2021 ◽  
Vol 351 ◽  
pp. 129338
Author(s):  
Jiayi Huang ◽  
Ka H. Wong ◽  
Wei Liang Tan ◽  
Stephanie V. Tay ◽  
Shujing Wang ◽  
...  
Keyword(s):  
Lycium Barbarum ◽  
Carboxypeptidase Inhibitor ◽  
Identification And Characterization

scholarly journals The disulfide folding pathway of potato carboxypeptidase inhibitor.

1994 ◽  
Vol 269 (35) ◽  
pp. 22087-22094
Author(s):  
J.Y. Chang ◽  
F. Canals ◽  
P. Schindler ◽  
E. Querol ◽  
F.X. Avilés
Keyword(s):  
Folding Pathway ◽  
Carboxypeptidase Inhibitor
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