Solution Structure and Dynamics of Oxytetracycline Polyketide Synthase Acyl Carrier Protein fromStreptomyces rimosus†,‡

Biochemistry ◽  
2003 ◽  
Vol 42 (28) ◽  
pp. 8423-8433 ◽  
Author(s):  
Stuart C. Findlow ◽  
Claire Winsor ◽  
Thomas J. Simpson ◽  
John Crosby ◽  
Matthew P. Crump
Keyword(s):  
Solution Structure ◽  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Carrier Protein ◽  
Structure And Dynamics

Solution Structure of an Acyl Carrier Protein Domain from a Fungal Type I Polyketide Synthase,

Biochemistry ◽  
2010 ◽  
Vol 49 (10) ◽  
pp. 2186-2193 ◽  
Author(s):  
Pakorn Wattana-amorn ◽  
Christopher Williams ◽  
Eliza Płoskoń ◽  
Russell J. Cox ◽  
Thomas J. Simpson ◽  
...  
Keyword(s):  
Solution Structure ◽  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domain ◽  
Carrier Protein ◽  
Type I

scholarly journals Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

2007 ◽  
Vol 16 (10) ◽  
pp. 2093-2107 ◽  
Author(s):  
Viktor Y. Alekseyev ◽  
Corey W. Liu ◽  
David E. Cane ◽  
Joseph D. Puglisi ◽  
Chaitan Khosla
Keyword(s):  
Solution Structure ◽  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domain ◽  
Carrier Protein ◽  
Modular Polyketide Synthase

Solution Structure of the Actinorhodin Polyketide Synthase Acyl Carrier Protein fromStreptomyces coelicolorA3(2)†,‡

Biochemistry ◽  
1997 ◽  
Vol 36 (20) ◽  
pp. 6000-6008 ◽  
Author(s):  
Matthew P. Crump ◽  
John Crosby ◽  
Christopher E. Dempsey ◽  
John A. Parkinson ◽  
Martin Murray ◽  
...  
Keyword(s):  
Solution Structure ◽  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Carrier Protein

scholarly journals Sticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthase

2016 ◽  
Vol 473 (8) ◽  
pp. 1097-1110 ◽  
Author(s):  
Steven Vance ◽  
Olga Tkachenko ◽  
Ben Thomas ◽  
Mona Bassuni ◽  
Hui Hong ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domain ◽  
Carrier Protein ◽  
Protein Surface ◽  
Prosthetic Group ◽  
Polyketide Biosynthesis ◽  
Covalently Linked

When covalently linked to an acyl carrier protein (ACP) and loaded with acyl substrate-mimics, some 4′-phosphopantetheine prosthetic group arms swing freely, whereas others stick to the protein surface, suggesting a possible mode of interaction with enzyme domains during polyketide biosynthesis.

scholarly journals Modular type I polyketide synthase acyl carrier protein domains share a common N-terminally extended fold

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Luisa Moretto ◽  
Rachel Heylen ◽  
Natalie Holroyd ◽  
Steven Vance ◽  
R. William Broadhurst
Keyword(s):  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Protein Domains ◽  
Carrier Protein ◽  
Type I

scholarly journals Solution Structure of B. subtilis Acyl Carrier Protein

Structure ◽  
2001 ◽  
Vol 9 (4) ◽  
pp. 277-287 ◽  
Author(s):  
Guang-Yi Xu ◽  
Amy Tam ◽  
Laura Lin ◽  
Jeffrey Hixon ◽  
Christian C. Fritz ◽  
...  
Keyword(s):  
Solution Structure ◽  
Acyl Carrier Protein ◽  
Carrier Protein

scholarly journals Active site labeling of fatty acid and polyketide acyl-carrier protein transacylases

2019 ◽  
Vol 17 (19) ◽  
pp. 4720-4724 ◽  
Author(s):  
Tony D. Davis ◽  
Jennifer M. Michaud ◽  
Michael D. Burkart
Keyword(s):  
Fatty Acid ◽  
Fluorescent Probe ◽  
Active Site ◽  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Site Directed Mutagenesis ◽  
Probe Design ◽  
Directed Mutagenesis ◽  
Carrier Protein

Fluorescent probe design and site-directed mutagenesis unveil new activity-based chemical reporters for fatty acid and polyketide synthase acyl-carrier protein transacylases.

An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein

ChemBioChem ◽  
2008 ◽  
Vol 9 (15) ◽  
pp. 2424-2432 ◽  
Author(s):  
Simon E. Evans ◽  
Christopher Williams ◽  
Christopher J. Arthur ◽  
Steven G. Burston ◽  
Thomas J. Simpson ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Acyl Carrier Protein ◽  
Carrier Protein
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