scholarly journals Interfacial Anchor Properties of Tryptophan Residues in Transmembrane Peptides Can Dominate over Hydrophobic Matching Effects in Peptide−Lipid Interactions†

Biochemistry ◽  
2003 ◽  
Vol 42 (18) ◽  
pp. 5341-5348 ◽  
Author(s):  
Maurits R. R. de Planque ◽  
Boyan B. Bonev ◽  
Jeroen A. A. Demmers ◽  
Denise V. Greathouse ◽  
Roger E. Koeppe ◽  
...  
Keyword(s):  
Transmembrane Peptides ◽  
Lipid Interactions ◽  
Tryptophan Residues ◽  
Hydrophobic Matching

A new concept in polytopic membrane proteins following from the study of band 3 protein

1998 ◽  
Vol 76 (5) ◽  
pp. 729-733 ◽  
Author(s):  
Naotaka Hamasaki ◽  
Hiroyuki Kuma ◽  
Kazuhisa Ota ◽  
Masao Sakaguchi ◽  
Katsuyoshi Mihara
Keyword(s):  
Membrane Proteins ◽  
Transmembrane Domain ◽  
Band 3 ◽  
Band 3 Protein ◽  
Transmembrane Peptides ◽  
Lipid Interactions ◽  
Transmembrane Segments ◽  
Novel Concept ◽  
Polytopic Membrane Protein ◽  
Peptide Classification

In the present communication, we introduce a novel concept in multispanning polytopic membrane proteins revealed by the study of the band 3 protein. The transmembrane domain of such proteins can be divided into three categories, that is, hydrophilic loops connecting transmembrane peptides (category 1), portions embedded by peptide-peptide interactions (category 2), and portions embedded by peptide-lipid interactions (category 3). Category 2 peptides of polytopic membrane proteins were found to stably reside in the lipid bilayer without peptide-lipid interactions that had been thought to be essential for transmembrane segments. Category 3 peptides are equivalent to single-spanning segments of bitopic membrane proteins. Three different experiments, namely proteolytic digestion, chemical modification of the band 3 protein, and cell free transcription and translation, were used to categorize the transmembrane peptides.Key words: band 3 protein, transmembrane (TM) peptide, classification of TM, category 2-TM, polytopic membrane protein.

scholarly journals The Effect of Hydrophobic Matching between Lipids and Transmembrane Peptides on Sterol Bilayer Affinity

2014 ◽  
Vol 106 (2) ◽  
pp. 515a-516a
Author(s):  
Kristian Ijäs ◽  
Max Lönnfors ◽  
Thomas K.M. Nyholm
Keyword(s):  
Transmembrane Peptides ◽  
Hydrophobic Matching
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