Site-Specific Dephosphorylation of Endothelial Nitric Oxide Synthase by Protein Phosphatase 2A:  Evidence for Crosstalk between Phosphorylation Sites†

Daniel M. Greif; Ruqin Kou; Thomas Michel

doi:10.1021/bi026732g

Site-Specific Dephosphorylation of Endothelial Nitric Oxide Synthase by Protein Phosphatase 2A: Evidence for Crosstalk between Phosphorylation Sites†

Biochemistry ◽

10.1021/bi026732g ◽

2002 ◽

Vol 41 (52) ◽

pp. 15845-15853 ◽

Cited By ~ 81

Author(s):

Daniel M. Greif ◽

Ruqin Kou ◽

Thomas Michel

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Protein Phosphatase ◽

Endothelial Nitric Oxide Synthase ◽

Protein Phosphatase 2A ◽

Phosphorylation Sites ◽

Site Specific ◽

Phosphatase 2A ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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B56δ subunit of protein phosphatase 2A decreases phosphorylation of endothelial nitric oxide synthase at serine 116: Mechanism underlying aphidicolin-stimulated NO production

Nitric Oxide ◽

10.1016/j.niox.2015.08.001 ◽

2015 ◽

Vol 50 ◽

pp. 46-51 ◽

Cited By ~ 2

Author(s):

Jung-Hyun Park ◽

Du-Hyong Cho ◽

Jee Young Lee ◽

Hyeon-Ju Lee ◽

Yena Ha ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Protein Phosphatase ◽

Endothelial Nitric Oxide Synthase ◽

Protein Phosphatase 2A ◽

No Production ◽

Phosphatase 2A ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Transcriptional Regulation of Endothelial Nitric-oxide Synthase by an Interaction between Casein Kinase 2 and Protein Phosphatase 2A

Journal of Biological Chemistry ◽

10.1074/jbc.274.49.34669 ◽

1999 ◽

Vol 274 (49) ◽

pp. 34669-34675 ◽

Cited By ~ 39

Author(s):

Katarzyna Cieslik ◽

Chii-Ming Lee ◽

Jih-Luh Tang ◽

Kenneth K. Wu

Keyword(s):

Nitric Oxide ◽

Transcriptional Regulation ◽

Nitric Oxide Synthase ◽

Protein Phosphatase ◽

Endothelial Nitric Oxide Synthase ◽

Protein Phosphatase 2A ◽

Casein Kinase ◽

Phosphatase 2A ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Interplay of myosin phosphatase and protein phosphatase-2A in the regulation of endothelial nitric-oxide synthase phosphorylation and nitric oxide production

Scientific Reports ◽

10.1038/srep44698 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 5

Author(s):

Róbert Bátori ◽

Bálint Bécsi ◽

Dénes Nagy ◽

Zoltán Kónya ◽

Csaba Hegedűs ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Protein Phosphatase ◽

Endothelial Nitric Oxide Synthase ◽

Nitric Oxide Production ◽

Myosin Phosphatase ◽

Oxide Production ◽

Phosphatase 2A ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Protein phosphatase 2A B56α mediates retinoic acid‐induced decreases in phosphorylation of endothelial nitric oxide synthase at serine 1179 and nitric oxide production

The FASEB Journal ◽

10.1096/fasebj.27.1_supplement.1051.3 ◽

2013 ◽

Vol 27 (S1) ◽

Author(s):

Inho Jo ◽

Jung‐Hyun Park ◽

Hye Youn Sung ◽

Jee Young Lee ◽

Hyun Jin Kim ◽

...

Keyword(s):

Nitric Oxide ◽

Retinoic Acid ◽

Nitric Oxide Synthase ◽

Protein Phosphatase ◽

Endothelial Nitric Oxide Synthase ◽

Nitric Oxide Production ◽

Oxide Production ◽

Phosphatase 2A ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Identification of Flow-dependent Endothelial Nitric-oxide Synthase Phosphorylation Sites by Mass Spectrometry and Regulation of Phosphorylation and Nitric Oxide Production by the Phosphatidylinositol 3-Kinase Inhibitor LY294002

Journal of Biological Chemistry ◽

10.1074/jbc.274.42.30101 ◽

1999 ◽

Vol 274 (42) ◽

pp. 30101-30108 ◽

Cited By ~ 246

Author(s):

Byron Gallis ◽

Garry L. Corthals ◽

David R. Goodlett ◽

Hiroto Ueba ◽

Francis Kim ◽

...

Keyword(s):

Nitric Oxide ◽

Mass Spectrometry ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Kinase Inhibitor ◽

Nitric Oxide Production ◽

Phosphorylation Sites ◽

Phosphatidylinositol 3 Kinase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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The Basal Phosphorylation Sites of Endothelial Nitric Oxide Synthase at Serine (Ser)1177, Ser116, and Threonine (Thr)495in Rat Molar Epithelial Rests of Malassez

Journal of Periodontology ◽

10.1902/jop.2005.76.9.1513 ◽

2005 ◽

Vol 76 (9) ◽

pp. 1513-1519 ◽

Cited By ~ 5

Author(s):

Yüksel Korkmaz ◽

Wilhelm Bloch ◽

Klaus Addicks ◽

Kurt Schneider ◽

Michael A. Baumann ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Phosphorylation Sites ◽

Epithelial Rests Of Malassez ◽

Oxide Synthase ◽

Endothelial Nitric Oxide ◽

Rat Molar

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Compensatory Phosphorylation and Protein-Protein Interactions Revealed by Loss of Function and Gain of Function Mutants of Multiple Serine Phosphorylation Sites in Endothelial Nitric-oxide Synthase

Journal of Biological Chemistry ◽

10.1074/jbc.m211926200 ◽

2003 ◽

Vol 278 (17) ◽

pp. 14841-14849 ◽

Cited By ~ 169

Author(s):

Philip M. Bauer ◽

David Fulton ◽

Yong Chool Boo ◽

George P. Sorescu ◽

Bruce E. Kemp ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Protein Interactions ◽

Endothelial Nitric Oxide Synthase ◽

Serine Phosphorylation ◽

Phosphorylation Sites ◽

Loss Of Function ◽

Protein Protein Interactions ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Endotoxin Conditioning Induces VCP/p97-mediated and Inducible Nitric-oxide Synthase-dependent Tyr284Nitration in Protein Phosphatase 2A

Journal of Biological Chemistry ◽

10.1074/jbc.m109.099788 ◽

2010 ◽

Vol 285 (12) ◽

pp. 8711-8718 ◽

Cited By ~ 31

Author(s):

Takashi Ohama ◽

David L. Brautigan

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Phosphatase 2A ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Arsenite Acutely Decreases Nitric Oxide Production via the ROS—Protein Phosphatase 1—Endothelial Nitric Oxide Synthase-Thr497Signaling Cascade

Biomolecules & Therapeutics ◽

10.4062/biomolther.2014.106 ◽

2014 ◽

Vol 22 (6) ◽

pp. 510-518 ◽

Cited By ~ 9

Author(s):

Jungwon Seo ◽

Jee Young Lee ◽

Min-Sun Sung ◽

Catherine Jeonghae Byun ◽

Du-Hyong Cho ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Protein Phosphatase ◽

Endothelial Nitric Oxide Synthase ◽

Protein Phosphatase 1 ◽

Nitric Oxide Production ◽

Oxide Production ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Subcellular Targeting and Agonist-induced Site-specific Phosphorylation of Endothelial Nitric-oxide Synthase

Journal of Biological Chemistry ◽

10.1074/jbc.m207299200 ◽

2002 ◽

Vol 277 (42) ◽

pp. 39554-39560 ◽

Cited By ~ 74

Author(s):

Eva Gonzalez ◽

Ruqin Kou ◽

Alison J. Lin ◽

David E. Golan ◽

Thomas Michel

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Subcellular Targeting ◽

Site Specific ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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