The Crystal Structure of Eosinophil Cationic Protein in Complex with 2‘,5‘-ADP at 2.0 Å Resolution Reveals the Details of the Ribonucleolytic Active Site†,‡

Biochemistry ◽  
2002 ◽  
Vol 41 (40) ◽  
pp. 12100-12106 ◽  
Author(s):  
C. Gopi Mohan ◽  
Ester Boix ◽  
Hazel R. Evans ◽  
Zoran Nikolovski ◽  
M. Victòria Nogués ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Active Site ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein

Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 Å resolution11Edited by R. Huber

2000 ◽  
Vol 300 (5) ◽  
pp. 1297-1307 ◽  
Author(s):  
Goretti Mallorquı́-Fernández ◽  
Joan Pous ◽  
Rosa Peracaula ◽  
Joan Aymamı́ ◽  
Takashi Maeda ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Three Dimensional ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein ◽  
Human Eosinophil ◽  
Dimensional Crystal

Crystal Structure of Eosinophil Cationic Protein at 2.4 Å Resolution†,‡

Biochemistry ◽  
1999 ◽  
Vol 38 (51) ◽  
pp. 16794-16801 ◽  
Author(s):  
Ester Boix ◽  
Demetres D. Leonidas ◽  
Zoran Nikolovski ◽  
M. Victòria Nogués ◽  
Claudi M. Cuchillo ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein

scholarly journals Blood eosinophils and serum eosinophil cationic protein in patients with acute and chronic urticaria

1996 ◽  
Vol 5 (2) ◽  
pp. 113-115 ◽  
Author(s):  
G. Di Lorenzo ◽  
P. Mansueto ◽  
M. Melluso ◽  
G. Candore ◽  
D. Cigna ◽  
...  
Keyword(s):  
Chronic Urticaria ◽  
Eosinophil Cationic Protein ◽  
Chronic Idiopathic Urticaria ◽  
Blood Eosinophil ◽  
Cationic Protein ◽  
Acute Urticaria ◽  
Asymptomatic Patients ◽  
The Moment ◽  
Blood Eosinophils ◽  
Eosinophil Counts

We have analysed the relationship of blood eosinophil count and serum eosinophil cationic protein (ECP) levels in patients with acute and chronic idiopathic urticaria. The ECP levels and eosinophil counts were measured in the peripheral blood of 15 patients with acute urticaria, 25 with chronic idiopathic urticaria and 10 normal healthy subjects. Blood eosinophil counts and serum ECP levels increased in all patients with acute urticaria. Concerning patients affected by chronic urticaria, taking into account the recrudescence of the disease at the moment of taking the blood sample, only symptomatic patients showed increased eosinophil blood values whereas serum ECP levels were increased both in symptomatic and asymptomatic patients. Furthermore, serum ECP levels in chronic urticaria did not correlate with the peripheral eosinophil counts, as they did in acute urticaria. The results of the present study indicate that eosinophils may play a role in the inflammatory mechanisms in patients with acute and chronic urticaria showing a positive correlation between serum ECP levels and disease activity.

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