The Novel Binding Mode ofN-Alkyl-N‘-hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis†

Huiying Li; Hideaki Shimizu; Mack Flinspach; Joumana Jamal; Weiping Yang; Ming Xian; Tingwei Cai; Edward Zhong Wen; Qiang Jia; Peng George Wang; Thomas L. Poulos

doi:10.1021/bi020417c

The Novel Binding Mode ofN-Alkyl-N‘-hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis†

Biochemistry ◽

10.1021/bi020417c ◽

2002 ◽

Vol 41 (47) ◽

pp. 13868-13875 ◽

Cited By ~ 89

Author(s):

Huiying Li ◽

Hideaki Shimizu ◽

Mack Flinspach ◽

Joumana Jamal ◽

Weiping Yang ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Binding Mode ◽

The Novel ◽

Oxide Synthase

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New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.06.025 ◽

2012 ◽

Vol 20 (17) ◽

pp. 5296-5304 ◽

Cited By ~ 9

Author(s):

Elodie Lohou ◽

Jana Sopkova-de Oliveira Santos ◽

Pascale Schumann-Bard ◽

Michel Boulouard ◽

Silvia Stiebing ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Active Site ◽

Neuronal Nitric Oxide Synthase ◽

Binding Mode ◽

Oxide Synthase

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Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations

Journal of the American Chemical Society ◽

10.1021/ja302269r ◽

2012 ◽

Vol 134 (28) ◽

pp. 11559-11572 ◽

Cited By ~ 13

Author(s):

He Huang ◽

Haitao Ji ◽

Huiying Li ◽

Qing Jing ◽

Kristin Jansen Labby ◽

...

Keyword(s):

Nitric Oxide ◽

Molecular Dynamics ◽

Nitric Oxide Synthase ◽

Molecular Dynamics Simulations ◽

Neuronal Nitric Oxide Synthase ◽

Binding Mode ◽

Dynamics Simulations ◽

Oxide Synthase

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Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure

Brain Research ◽

10.1016/s0006-8993(96)00620-8 ◽

1996 ◽

Vol 734 (1-2) ◽

pp. 109-115 ◽

Cited By ~ 76

Author(s):

K Patel

Keyword(s):

Gene Expression ◽

Nitric Oxide ◽

Heart Failure ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Oxide Synthase

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Role of neuronal nitric oxide synthase in gastric hypermotility induced by intracisternal TRH analog, RX 77368, in anesthetized rats

Gastroenterology ◽

10.1016/s0016-5085(01)82651-2 ◽

2001 ◽

Vol 120 (5) ◽

pp. A533-A534

Author(s):

K KANAMOTO ◽

K KAWAKUBO ◽

D ADELSON ◽

Y TACHE

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Anesthetized Rats ◽

Oxide Synthase

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Optical density analysis of levels of neuronal nitric oxide synthase (nNOS), substance P (SP) and catechoalmines in myenteric ganglia of lleum, proximal colon (PC) and distal colon (DC) from vehicle-and streptozotocin (STZ)-treated guinea pigs

Gastroenterology ◽

10.1016/s0016-5085(01)81666-8 ◽

2001 ◽

Vol 120 (5) ◽

pp. A335-A335

Author(s):

K LEPARD ◽

R PORTER

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Substance P ◽

Guinea Pigs ◽

Neuronal Nitric Oxide Synthase ◽

Distal Colon ◽

Proximal Colon ◽

Density Analysis ◽

Oxide Synthase ◽

Myenteric Ganglia

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Colocalization of neuronal nitric oxide synthase and calretinin in the mouse hippocampus: quantitative and morphometric analysis with optical disector

Neuroscience Research ◽

10.1016/s0168-0102(00)81186-4 ◽

2000 ◽

Vol 38 ◽

pp. S57

Author(s):

S Jinno

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Morphometric Analysis ◽

Neuronal Nitric Oxide Synthase ◽

Optical Disector ◽

Mouse Hippocampus ◽

Oxide Synthase

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Effects of endothelial and neuronal nitric oxide synthase inhibitors on release of amino acids from hippocampus after transient forebrain ischemia

Neuroscience Research ◽

10.1016/s0168-0102(00)81713-7 ◽

2000 ◽

Vol 38 ◽

pp. S144

Author(s):

M Jiang

Keyword(s):

Nitric Oxide ◽

Amino Acids ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Forebrain Ischemia ◽

Nitric Oxide Synthase Inhibitors ◽

Transient Forebrain Ischemia ◽

Oxide Synthase

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Faculty Opinions recommendation of Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031032.363473 ◽

2006 ◽

Author(s):

Henry Lin

Keyword(s):

Nitric Oxide ◽

Stem Cell ◽

Nitric Oxide Synthase ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Neural Stem Cell ◽

Neuronal Nitric Oxide Synthase ◽

Gastric Function ◽

Oxide Synthase ◽

Deficient Mice

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Faculty Opinions recommendation of Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1082853.542682 ◽

2007 ◽

Author(s):

Arthur Christopoulos

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Serotonin Transporter ◽

Neuronal Nitric Oxide Synthase ◽

Physical Interaction ◽

Oxide Synthase

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Faculty Opinions recommendation of Nuclear recruitment of neuronal nitric-oxide synthase by α-syntrophin is crucial for the induction of mitochondrial biogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718176862.793531928 ◽

2017 ◽

Author(s):

Yin Hua Zhang

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Mitochondrial Biogenesis ◽

Neuronal Nitric Oxide Synthase ◽

Oxide Synthase

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