Cation- and Peptide-Binding Properties of Human Calmodulin-like Skin Protein†

Biochemistry ◽  
2002 ◽  
Vol 41 (17) ◽  
pp. 5439-5448 ◽  
Author(s):  
Isabelle Durussel ◽  
Bruno Méhul ◽  
Dominique Bernard ◽  
Rainer Schmidt ◽  
Jos A. Cox
Keyword(s):  
Peptide Binding ◽  
Binding Properties ◽  
Skin Protein

Syntheses and Selective Peptide-Binding Properties of Metallomacrocycles.

ChemInform ◽  
2004 ◽  
Vol 35 (14) ◽  
Author(s):  
Kum Hee Lee ◽  
Seung Soo Yoon
Keyword(s):  
Peptide Binding ◽  
Binding Properties

Synthesis and Peptide Binding Properties of Methoxypyrrole Amino Acids (MOPAS)

2004 ◽  
Vol 6 (9) ◽  
pp. 1349-1352 ◽  
Author(s):  
Christoph Bonauer ◽  
Manfred Zabel ◽  
Burkhard König
Keyword(s):  
Amino Acids ◽  
Peptide Binding ◽  
Binding Properties

Evidence for an effect of human leukocyte antigens on susceptibility to Kaposiʼs sarcoma related to charge and peptide-binding properties of class I molecules

AIDS ◽  
1995 ◽  
Vol 9 (10) ◽  
pp. 1194 ◽  
Author(s):  
M. Marmor ◽  
R. Winchester ◽  
A. Zeleniuch-Jacquotte ◽  
S. H. Weiss ◽  
K. Krasmski ◽  
...  
Keyword(s):  
Peptide Binding ◽  
Human Leukocyte ◽  
Class I ◽  
Human Leukocyte Antigens ◽  
Binding Properties ◽  
Leukocyte Antigens

scholarly journals HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection

2016 ◽  
Vol 68 (6-7) ◽  
pp. 401-416 ◽  
Author(s):  
Stéphane Buhler ◽  
José Manuel Nunes ◽  
Alicia Sanchez-Mazas
Keyword(s):  
Peptide Binding ◽  
Hla Class I ◽  
Class I ◽  
Molecular Variation ◽  
Binding Properties

Sensory neurons with MHC-like peptide binding properties: disease consequences

2006 ◽  
Vol 18 (5) ◽  
pp. 608-616 ◽  
Author(s):  
Patricia R. Slev ◽  
Adam C. Nelson ◽  
Wayne K Potts
Keyword(s):  
Sensory Neurons ◽  
Peptide Binding ◽  
Binding Properties

scholarly journals Structure, Composition, and Peptide Binding Properties of Detergent Soluble Bilayers and Detergent Resistant Rafts

2002 ◽  
Vol 82 (3) ◽  
pp. 1469-1482 ◽  
Author(s):  
M. Gandhavadi ◽  
D. Allende ◽  
A. Vidal ◽  
S.A. Simon ◽  
T.J. McIntosh
Keyword(s):  
Peptide Binding ◽  
Binding Properties

scholarly journals Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity

2021 ◽  
Vol 12 ◽  
Author(s):  
Johannes Schetelig ◽  
Falk Heidenreich ◽  
Henning Baldauf ◽  
Sarah Trost ◽  
Bose Falk ◽  
...  
Keyword(s):  
T Cell ◽  
Peptide Binding ◽  
T Cell Response ◽  
Heterozygote Advantage ◽  
T Cell Epitopes ◽  
Binding Properties ◽  
Cell Responses ◽  
Major Factors ◽  
The Impact ◽  
Hla Molecules

HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data from 6,919 infected individuals. HLA-A, -B, and -DRB1 allotypes grouped into HLA supertypes by functional or predicted structural similarities of the peptide-binding grooves did not predict COVID-19 severity. Further, we did not observe a heterozygote advantage or a benefit from HLA diplotypes with more divergent physicochemical peptide-binding properties. Finally, numbers of in silico predicted viral T-cell epitopes did not correlate with the severity of SARS-CoV-2 infections. These findings suggest that the HLA genotype is no major factor determining COVID-19 severity. Moreover, our data suggest that the spike glycoprotein alone may allow for abundant T-cell epitopes to mount robust T-cell responses not limited by the HLA genotype.

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