How Helminth Lipid-Binding Proteins Offload Their Ligands to Membranes:  Differential Mechanisms of Fatty Acid Transfer by the ABA-1 Polyprotein Allergen and Ov-FAR-1 Proteins of Nematodes and Sj-FABPc of Schistosomes†

Biochemistry ◽  
2002 ◽  
Vol 41 (21) ◽  
pp. 6706-6713 ◽  
Author(s):  
Lindsay McDermott ◽  
Malcolm W. Kennedy ◽  
Donald P. McManus ◽  
Jan E. Bradley ◽  
Alan Cooper ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Binding Proteins ◽  
Lipid Binding ◽  
Lipid Binding Proteins

Intracellular fatty acid trafficking and the role of cytosolic lipid binding proteins

1989 ◽  
Vol 28 (4) ◽  
pp. 245-272 ◽  
Author(s):  
Valerie Matarese ◽  
Randy L. Stone ◽  
David W. Waggoner ◽  
David A. Bernlohr
Keyword(s):  
Fatty Acid ◽  
Binding Proteins ◽  
Lipid Binding ◽  
Lipid Binding Proteins

Lipid absorptions passing through the unstirred layers, brush-border membrane, and beyond

1993 ◽  
Vol 71 (8) ◽  
pp. 531-555 ◽  
Author(s):  
A. B. R. Thomson ◽  
C. Schoeller ◽  
M. Keelan ◽  
L. Smith ◽  
M. T. Clandinin
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Brush Border ◽  
Binding Proteins ◽  
Brush Border Membrane ◽  
Water Layer ◽  
Lipid Binding ◽  
Dietary Lipids ◽  
Unstirred Water Layer ◽  
Lipid Binding Proteins

Lipids are components of our diet and luminal secretions, with physicochemical characteristics that determine their digestion and absorption in the gastrointestinal tract. Lipids include triglycerides, phospholipids, and cholesterol. Dietary lipids contain approximately 97% triglycerides, with small amounts of phospholipids and cholesterol. These components are important in cell membrane composition, fluidity, peroxidation, prostaglandin and leukotriene synthesis, and cellular metabolic processes. Lipids are implicated in the mechanisms of brain development, inflammatory processes, atherosclerosis, carcinogenesis, aging, and cell renewal. Duodenal hydrolysis of dietary lipids and biliary phospholipids and cholesterol is carried out by pancreatic lipase, colipase, phospholipase A2, and cholesterol esterase. Bile acid solubilization results in mixed micelles and liposomes, in gel and liquid crystal phases. Lipid digestion products pass across the intestinal unstirred water layer. For long-chain fatty acids and cholesterol, passage across the unstirred water layer is rate limiting, whereas passage of short- and medium-chain fatty acids is limited by the brush-border membrane. Within the unstirred water layer, an acidic microclimate aids micellar dissociation so that protonated, and to a lesser extent, nonprotonated monomers then pass across the intestinal brush-border membrane. Absorptive mechanisms have been studied extensively in relation to lipid composition, fatty acid chain length, degree of unsaturation, essential fatty acid content, phospholipid components, and cholesterol. Enterocytes may take up lipids from the intestinal lumen or from lipoproteins of the bloodstream, but these pools are likely to be functionally distinct. Recent advances are reviewed, including recent advances in the area of microclimates, compartmentation, lipid binding proteins, intracellular trafficking, intestinal lipoproteins, release of lipids across the basolateral membrane, and dietary effects.Key words: diet effects, lipid binding proteins, lipoproteins.

From fatty-acid sensing to chylomicron synthesis: Role of intestinal lipid-binding proteins

Biochimie ◽  
2014 ◽  
Vol 96 ◽  
pp. 37-47 ◽  
Author(s):  
Marjorie Buttet ◽  
Véronique Traynard ◽  
Thi Thu Trang Tran ◽  
Philippe Besnard ◽  
Hélène Poirier ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Binding Proteins ◽  
Lipid Binding ◽  
Lipid Binding Proteins ◽  
Fatty Acid Sensing

Lipid-Binding Proteins: A Family of Fatty Acid and Retinoid Transport Proteins

1994 ◽  
pp. 89-151 ◽  
Author(s):  
Leonard Banaszak ◽  
Nathan Winter ◽  
Zhaohui Xu ◽  
David A. Bernlohr ◽  
Sandra Cowan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Binding Proteins ◽  
Lipid Binding ◽  
Transport Proteins ◽  
Lipid Binding Proteins

The role of dynamics in modulating ligand exchange in intracellular lipid binding proteins

2014 ◽  
Vol 1844 (7) ◽  
pp. 1268-1278 ◽  
Author(s):  
Laura Ragona ◽  
Katiuscia Pagano ◽  
Simona Tomaselli ◽  
Filippo Favretto ◽  
Alberto Ceccon ◽  
...  
Keyword(s):  
Ligand Exchange ◽  
Binding Proteins ◽  
Lipid Binding ◽  
Intracellular Lipid ◽  
Lipid Binding Proteins
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