scholarly journals Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein†

Biochemistry ◽  
2002 ◽  
Vol 41 (12) ◽  
pp. 3991-4001 ◽  
Author(s):  
Colin S. Burns ◽  
Eliah Aronoff-Spencer ◽  
Christine M. Dunham ◽  
Paula Lario ◽  
Nikolai I. Avdievich ◽  
...  
Keyword(s):  
Prion Protein ◽  
Binding Sites ◽  
Copper Binding ◽  
Molecular Features ◽  
Copper Binding Sites

scholarly journals Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Sun Huang ◽  
Stefanie A. Black ◽  
Junting Huang ◽  
Peter K. Stys ◽  
Gerald W. Zamponi
Keyword(s):  
Nmda Receptor ◽  
Prion Protein ◽  
Binding Sites ◽  
Hippocampal Neurons ◽  
Primary Cultures ◽  
Cellular Prion Protein ◽  
Null Mouse ◽  
Dependent Manner ◽  
Copper Binding ◽  
Copper Binding Sites

AbstractWe have previously reported that cellular prion protein (PrPC) can down-regulate NMDA receptor activity and in a copper dependent manner. Here, we employed AAV9 to introduce murine cellular prion protein into mouse hippocampal neurons in primary cultures from PrP null mice to determine the role of the six copper binding motifs located within the N-terminal domain of PrPC. The results demonstrate that viral expression of wild type PrPC lowers NMDAR activity in PrP null mouse hippocampal neurons by reducing the magnitude of non-desensitizing currents. Elimination of the last two copper binding sites alone, or in combination with the remaining four attenuates this protective effect. Thus our data suggest that copper ion interactions with specific binding sites on PrPC are critical for PrPC dependent modulation of NMDA receptor function.

Copper binding sites in the C‐terminal domain of mouse prion protein: A hybrid (QM/MM) molecular dynamics study

2008 ◽  
Vol 70 (3) ◽  
pp. 1084-1098 ◽  
Author(s):  
Maria Carola Colombo ◽  
Joost VandeVondele ◽  
Sabine Van Doorslaer ◽  
Alessandro Laio ◽  
Leonardo Guidoni ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Prion Protein ◽  
Binding Sites ◽  
Protein A ◽  
Copper Binding ◽  
Terminal Domain ◽  
Copper Binding Sites

Determination of copper binding sites in peptides containing basic residues: a combined experimental and theoretical study

2001 ◽  
Vol 204 (1-3) ◽  
pp. 31-46 ◽  
Author(s):  
Brian K. Bluhm ◽  
Sharon J. Shields ◽  
Craig A. Bayse ◽  
Michael B. Hall ◽  
David H. Russell
Keyword(s):  
Binding Sites ◽  
Theoretical Study ◽  
Copper Binding ◽  
Determination Of Copper ◽  
Copper Binding Sites

Scaffolded amino acids as a close structural mimic of type-3 copper binding sites

2007 ◽  
pp. 4895 ◽  
Author(s):  
H. Bauke Albada ◽  
Fouad Soulimani ◽  
Bert M. Weckhuysen ◽  
Rob M. J. Liskamp
Keyword(s):  
Amino Acids ◽  
Binding Sites ◽  
Copper Binding ◽  
Type 3 ◽  
Copper Binding Sites

scholarly journals Interactions between Copper-binding Sites Determine the Redox Status and Conformation of the Regulatory N-terminal Domain of ATP7B

2009 ◽  
Vol 285 (9) ◽  
pp. 6327-6336 ◽  
Author(s):  
Erik S. LeShane ◽  
Ujwal Shinde ◽  
Joel M. Walker ◽  
Amanda N. Barry ◽  
Ninian J. Blackburn ◽  
...  
Keyword(s):  
Binding Sites ◽  
Redox Status ◽  
Copper Binding ◽  
Terminal Domain ◽  
Copper Binding Sites

scholarly journals Measurement of Copper-Binding Sites on Low Density Lipoprotein

2001 ◽  
Vol 21 (4) ◽  
pp. 594-602 ◽  
Author(s):  
Alexander Roland ◽  
Rebecca A. Patterson ◽  
David S. Leake
Keyword(s):  
Binding Sites ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Copper Binding ◽  
Copper Binding Sites

Specific oxidation of copper binding sites in copper(II)-oligopeptide complexes

Biochemistry ◽  
1971 ◽  
Vol 10 (1) ◽  
pp. 64-66 ◽  
Author(s):  
Arieh Berger ◽  
Alexander Levitzki
Keyword(s):  
Binding Sites ◽  
Copper Binding ◽  
Specific Oxidation ◽  
Copper Binding Sites
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