Phenylalanine and Tryptophan Scanning Mutagenesis of CYP3A4 Substrate Recognition Site Residues and Effect on Substrate Oxidation and Cooperativity†

Biochemistry ◽  
2001 ◽  
Vol 40 (34) ◽  
pp. 10150-10160 ◽  
Author(s):  
Tammy L. Domanski ◽  
You-Ai He ◽  
Kishore K. Khan ◽  
Fabienne Roussel ◽  
Qinmi Wang ◽  
...  
Keyword(s):  
Substrate Recognition ◽  
Substrate Oxidation ◽  
Recognition Site ◽  
Cyp3a4 Substrate

The Role of Cytochrome 2B1 Substrate Recognition Site Residues 115, 294, 297, 298, and 362 in the Oxidation of Steroids and 7-Alkoxycoumarins

2001 ◽  
Vol 394 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Tammy L. Domanski ◽  
You-Qun He ◽  
Emily E. Scott ◽  
Qinmi Wang ◽  
James R. Halpert
Keyword(s):  
Substrate Recognition ◽  
Recognition Site

scholarly journals Structural Determinants of Aromatase Cytochrome P450 Inhibition in Substrate Recognition Site-1

2002 ◽  
Vol 16 (7) ◽  
pp. 1456-1468 ◽  
Author(s):  
Alan Conley ◽  
Samantha Mapes ◽  
C. Jo Corbin ◽  
Douglas Greger ◽  
Sandra Graham
Keyword(s):  
Cytochrome P450 ◽  
Substrate Recognition ◽  
Recognition Site ◽  
Structural Determinants

Analysis of Substrate Recognition Site 2 (SRS2) in human cytochrome P450 1A2 using whole-plasmid random mutagenesis

2013 ◽  
Vol 9 (1) ◽  
pp. 9-14
Author(s):  
Joohwan Kim ◽  
Songhee Han ◽  
Seunghye Choi ◽  
Hyoung-Goo Park ◽  
Young-Ran Lim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Substrate Recognition ◽  
Random Mutagenesis ◽  
Recognition Site ◽  
Cytochrome P450 1A2 ◽  
Human Cytochrome
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