Double-Stranded DNA Binding Characteristics and Subcellular Distribution of a Minor Groove Binding Diphenyl Ether Bisbenzimidazole†

Biochemistry ◽  
2001 ◽  
Vol 40 (21) ◽  
pp. 6465-6474 ◽  
Author(s):  
Alexander L. Satz ◽  
Christine M. White ◽  
Terry A. Beerman ◽  
Thomas C. Bruice
Keyword(s):  
Dna Binding ◽  
Subcellular Distribution ◽  
Diphenyl Ether ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Binding Characteristics ◽  
Double Stranded Dna ◽  
A Minor

A Minor Groove Binding Copper-Phenanthroline Conjugate Produces Direct Strand Breaks via β-Elimination of 2-Deoxyribonolactone

2002 ◽  
Vol 124 (31) ◽  
pp. 9062-9063 ◽  
Author(s):  
Brian C. Bales ◽  
Marguerite Pitié ◽  
Bernard Meunier ◽  
Marc M. Greenberg
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Strand Breaks ◽  
A Minor

Inhibition of DNA Binding by Human Estrogen-Related Receptor 2 and Estrogen Receptor α with Minor Groove Binding Polyamides†

Biochemistry ◽  
2005 ◽  
Vol 44 (11) ◽  
pp. 4196-4203 ◽  
Author(s):  
Micah D. Gearhart ◽  
Liliane Dickinson ◽  
Jennifer Ehley ◽  
Christian Melander ◽  
Peter B. Dervan ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Dna Binding ◽  
Minor Groove ◽  
Estrogen Receptor Α ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Estrogen Related Receptor

Netropsin, a Minor Groove Binding Ligand: A Potential Radioprotective Agent

2009 ◽  
Vol 172 (6) ◽  
pp. 698-705 ◽  
Author(s):  
K. Mishra ◽  
R. Bhardwaj ◽  
N. K. Chaudhury
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor ◽  
Radioprotective Agent

Development of a minor groove binding probe based real-time PCR for the diagnosis and quantification of Leishmania infantum in dog specimens

2011 ◽  
Vol 91 (2) ◽  
pp. 243-245 ◽  
Author(s):  
Elena Galletti ◽  
Paolo Bonilauri ◽  
Lia Bardasi ◽  
Maria Cristina Fontana ◽  
Mattia Ramini ◽  
...  
Keyword(s):  
Real Time ◽  
Real Time Pcr ◽  
Leishmania Infantum ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor

scholarly journals Photocontrolled DNA minor groove interactions of imidazole/pyrrole polyamides

2020 ◽  
Vol 16 ◽  
pp. 60-70 ◽  
Author(s):  
Sabrina Müller ◽  
Jannik Paulus ◽  
Jochen Mattay ◽  
Heiko Ihmels ◽  
Veronica I Dodero ◽  
...  
Keyword(s):  
Structural Changes ◽  
Photometric Determination ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Hairpins ◽  
Dna Minor Groove ◽  
H Nmr ◽  
Double Stranded Dna ◽  
Protein Dna Interactions

Azobenzenes are photoswitchable molecules capable of generating significant structural changes upon E-to-Z photoisomerization in peptides or small molecules, thereby controlling geometry and functionality. E-to-Z photoisomerization usually is achieved upon irradiation at 350 nm (π–π* transition), while the Z-to-E isomerization proceeds photochemically upon irradiation at >400 nm (n–π* transition) or thermally. Photoswitchable compounds have frequently been employed as modules, e.g., to control protein–DNA interactions. However, their use in conjunction with minor groove-binding imidazole/pyrrole (Im/Py) polyamides is yet unprecedented. Dervan-type Im/Py polyamides were equipped with an azobenzene unit, i.e., 3-(3-(aminomethyl)phenyl)azophenylacetic acid, as the linker between two Im/Py polyamide strands. Only the (Z)-azobenzene-containing polyamides bound to the minor groove of double-stranded DNA hairpins. Photoisomerization was exemplarily evaluated by 1H NMR experiments, while minor groove binding of the (Z)-azobenzene derivatives was proven by CD titration experiments. The resulting induced circular dichroism (ICD) bands of the bound ligands, together with the photometric determination of the dsDNA melting temperature, revealed a significant stabilization of the DNA upon association with the ligand. The (Z)-azobenzene acted as a building block inducing a reverse turn, which favored hydrogen bonds between the pyrrole/imidazole amide and the DNA bases. In contrast, the E-configured polyamides did not induce any ICD characteristic for minor groove binding. The incorporation of the photoswitchable azobenzene unit is a promising strategy to obtain photoswitchable Im/Py hairpin polyamides capable of interacting with the dsDNA minor groove only in the Z-configuration.

scholarly journals Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells

2018 ◽  
Vol 69 ◽  
pp. 119-122 ◽  
Author(s):  
Kourosh Hayatigolkhatmi ◽  
Giacomo Padroni ◽  
Wu Su ◽  
Lijing Fang ◽  
Eduardo Gómez-Castañeda ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor ◽  
E2f1 Transcription Factor

scholarly journals Direction of Intercalation of a bis-Ru(II) Complex to DNA Probed by a Minor Groove Binding Molecule 4',6-Diamidino-2-phenylindole

2013 ◽  
Vol 34 (10) ◽  
pp. 2895-2899
Author(s):  
Yoon Jung Jang ◽  
Raeyeong Kim ◽  
Nataraj Chitrapriya ◽  
Sung Wook Han ◽  
Seog K. Kim ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor
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