Mechanistic Studies on Thiamin Phosphate Synthase:  Evidence for a Dissociative Mechanism†

Biochemistry ◽  
2001 ◽  
Vol 40 (34) ◽  
pp. 10095-10102 ◽  
Author(s):  
Jason J. Reddick ◽  
Robb Nicewonger ◽  
Tadhg P. Begley
Keyword(s):  
Mechanistic Studies ◽  
Dissociative Mechanism ◽  
Thiamin Phosphate Synthase ◽  
Phosphate Synthase

Evolutionary Walk between (β/α)8 Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase

2012 ◽  
Vol 416 (2) ◽  
pp. 255-270 ◽  
Author(s):  
Gloria Saab-Rincón ◽  
Leticia Olvera ◽  
Maricela Olvera ◽  
Enrique Rudiño-Piñera ◽  
Eleuterio Benites ◽  
...  
Keyword(s):  
Triosephosphate Isomerase ◽  
Thiamin Phosphate Synthase ◽  
Phosphate Synthase

Mechanistic Studies on Pyridoxal Phosphate Synthase:  The Reaction Pathway Leading to a Chromophoric Intermediate

2008 ◽  
Vol 130 (10) ◽  
pp. 3043-3052 ◽  
Author(s):  
Jeremiah W. Hanes ◽  
Kristin E. Burns ◽  
David G. Hilmey ◽  
Abhishek Chatterjee ◽  
Pieter C. Dorrestein ◽  
...  
Keyword(s):  
Pyridoxal Phosphate ◽  
Reaction Pathway ◽  
Mechanistic Studies ◽  
Phosphate Synthase

Enzymatic and structural characterization of an archaeal thiamin phosphate synthase

2014 ◽  
Vol 1844 (4) ◽  
pp. 803-809 ◽  
Author(s):  
Maria Hayashi ◽  
Kazuya Kobayashi ◽  
Hiroyoshi Esaki ◽  
Hiroyuki Konno ◽  
Kenichi Akaji ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Thiamin Phosphate Synthase ◽  
Phosphate Synthase

Mechanistic studies of the reactions of 2-methylpropene with deuterium over supported metal catalysts

1989 ◽  
Vol 424 (1866) ◽  
pp. 39-56 ◽  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Metal Catalysts ◽  
Supported Metal Catalysts ◽  
Mechanistic Studies ◽  
Dissociative Mechanism ◽  
Methyl Group ◽  
Methylene Groups ◽  
Methylene Group ◽  
Supported Metal

Deuterium NMR spectroscopy, gas chromatography and mass spectrometry have been used to examine the products from the reaction of 2-methylpropene with deuterium over supported metal catalysts. The detailed information, so obtained, about the number, location and grouping of deuterium atoms in both the exchanged alkenes and the 2-methylpropanes formed by addition provided evidence about possible mechanisms. With palladium, exchange was faster than addition and the deuterium atoms were randomly distributed in the alkene, probably through a π-allyl dissociative mechanism. With platinum and rhodium, exchange occurred preferentially in the methylene groups of the alkene and the results indicated a dissociative mechanism involving adsorbed vinyl intermediates together with some intramolecular double-bond movement through a π-allyl type of species. Relatively little exchange occurred with iridium. The activities of the metals for production of alkane at 235 K were Rh > Ir > Pd > Pt but the spread was only a factor of about 20. With all metals except palladium further exchange occurred during the addition process, but this was mainly concentrated in one methyl group. This behaviour was explained in terms of mechanisms that permitted additional exchange of the methylene group of the alkene to take place during the addition process.

Crystal Structure of Thiamin Phosphate Synthase fromBacillus subtilisat 1.25 Å Resolution†,‡

Biochemistry ◽  
1999 ◽  
Vol 38 (20) ◽  
pp. 6460-6470 ◽  
Author(s):  
Hsiu-Ju Chiu ◽  
Jason J. Reddick ◽  
Tadhg P. Begley ◽  
Steven E. Ealick
Keyword(s):  
Crystal Structure ◽  
Thiamin Phosphate Synthase ◽  
Phosphate Synthase

Structural Characterization of the Enzyme−Substrate, Enzyme−Intermediate, and Enzyme−Product Complexes of Thiamin Phosphate Synthase†,‡

Biochemistry ◽  
2001 ◽  
Vol 40 (34) ◽  
pp. 10103-10114 ◽  
Author(s):  
Diane H. Peapus ◽  
Hsiu-Ju Chiu ◽  
Nino Campobasso ◽  
Jason J. Reddick ◽  
Tadhg P. Begley ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Enzyme Product ◽  
Enzyme Substrate ◽  
Thiamin Phosphate Synthase ◽  
Enzyme Intermediate ◽  
Phosphate Synthase

scholarly journals Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans

2018 ◽  
Vol 04 (01) ◽  
Author(s):  
Sumit Handa ◽  
Daniel R Dempsey ◽  
Divya Ramamoorthy ◽  
Nanci Cook ◽  
Wayne C Guida ◽  
...  
Keyword(s):  
Deinococcus Radiodurans ◽  
Mechanistic Studies ◽  
Phosphate Synthase
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