Role of Aromatic Stacking Interactions in the Modulation of the Two-Electron Reduction Potentials of Flavin and Substrate/Product inMegasphaera elsdeniiShort-Chain Acyl-Coenzyme A Dehydrogenase†

Biochemistry ◽  
2001 ◽  
Vol 40 (25) ◽  
pp. 7720-7728 ◽  
Author(s):  
Jackson D. Pellett ◽  
Donald F. Becker ◽  
Amy K. Saenger ◽  
James A. Fuchs ◽  
Marian T. Stankovich
Keyword(s):  
Coenzyme A ◽  
Stacking Interactions ◽  
Aromatic Stacking ◽  
Reduction Potentials ◽  
Chain Acyl ◽  
Electron Reduction ◽  
Acyl Coenzyme A

Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling

2018 ◽  
Vol 132 (3) ◽  
pp. 381-397 ◽  
Author(s):  
Bianca C. Bernardo ◽  
Kate L. Weeks ◽  
Thawin Pongsukwechkul ◽  
Xiaoming Gao ◽  
Helen Kiriazis ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Coenzyme A ◽  
Healthy Adult ◽  
Capillary Density ◽  
Medium Chain ◽  
Adult Mice ◽  
Physiological Cardiac Hypertrophy ◽  
Chain Acyl ◽  
Acyl Coenzyme A

We previously showed that medium chain acyl-coenzyme A dehydrogenase (MCAD, key regulator of fatty acid oxidation) is positively modulated in the heart by the cardioprotective kinase, phosphoinositide 3-kinase (PI3K(p110α)). Disturbances in cardiac metabolism are a feature of heart failure (HF) patients and targeting metabolic defects is considered a potential therapeutic approach. The specific role of MCAD in the adult heart is unknown. To examine the role of MCAD in the heart and to assess the therapeutic potential of increasing MCAD in the failing heart, we developed a gene therapy tool using recombinant adeno-associated viral vectors (rAAV) encoding MCAD. We hypothesised that increasing MCAD expression may recapitulate the cardioprotective properties of PI3K(p110α). rAAV6:MCAD or rAAV6:control was delivered to healthy adult mice and to mice with pre-existing pathological hypertrophy and cardiac dysfunction due to transverse aortic constriction (TAC). In healthy mice, rAAV6:MCAD induced physiological hypertrophy (increase in heart size, normal systolic function and increased capillary density). In response to TAC (~15 weeks), heart weight/tibia length increased by ~60% in control mice and ~45% in rAAV6:MCAD mice compared with sham. This was associated with an increase in cardiomyocyte cross-sectional area in both TAC groups which was similar. However, hypertrophy in TAC rAAV6:MCAD mice was associated with less fibrosis, a trend for increased capillary density and a more favourable molecular profile compared with TAC rAAV6:control mice. In summary, MCAD induced physiological cardiac hypertrophy in healthy adult mice and attenuated features of pathological remodelling in a cardiac disease model.

MRI in medium-chain acyl-coenzyme a dehydrogenase deficiency: neuroimaging during the first month

2017 ◽  
Vol 30 (8) ◽  
Author(s):  
Lorenzo Figà Talamanca ◽  
Luca Pasquini ◽  
Antonio Napolitano ◽  
Daniela Longo
Keyword(s):  
Coenzyme A ◽  
Genetic Disorder ◽  
Brain Magnetic Resonance Imaging ◽  
Acid Oxidation ◽  
Medium Chain ◽  
Chain Acyl ◽  
Magnetic Resonance Imaging Mri ◽  
Acyl Coenzyme A ◽  
Mri Changes

AbstractBackground:Medium-chain acyl-coenzyme A dehydrogenase (MCAD) is the most common genetic disorder of fatty acid oxidation, which presents before the age of 2 with the onset of acute hypoketotic hypoglycemia, and is typically precipitated by stress.Case presentation:We report serial brain magnetic resonance imaging (MRI) changes, including MR spectroscopy (MRS) and diffusion weighted imaging (DWI), in a patient with a classical MCAD presentation, compared with five healthy controls.Conclusions:Through this unique case we analyze the evolution of radiological findings during the first month of illness and we highlight the pivotal role of MRI, especially DWI, in the early diagnosis of the decompensated state of the disease.

Role of very-long-chain acyl-coenzyme A synthetase in X-linked adrenoleukodystrophy

1999 ◽  
Vol 46 (3) ◽  
pp. 409-412 ◽  
Author(s):  
Steven J. Steinberg ◽  
Stephan Kemp ◽  
Lelita T. Braiterman ◽  
Paul A. Watkins
Keyword(s):  
Coenzyme A ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Long Chain

scholarly journals The role of OleA His285 in orchestration of long-chain acyl-coenzyme A substrates

FEBS Letters ◽  
2018 ◽  
Vol 592 (6) ◽  
pp. 987-998 ◽  
Author(s):  
Matthew R. Jensen ◽  
Brandon R. Goblirsch ◽  
Morgan A. Esler ◽  
James K. Christenson ◽  
Fatuma A. Mohamed ◽  
...  
Keyword(s):  
Coenzyme A ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Long Chain

scholarly journals Mechanism of the control of (Na+ + K+)-ATPase by long-chain acyl coenzyme A

1989 ◽  
Vol 264 (5) ◽  
pp. 2605-2608
Author(s):  
W H Huang ◽  
Y Wang ◽  
A Askari
Keyword(s):  
Coenzyme A ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Long Chain

Interaction of acyl coenzyme A substrates and analogs with pig kidney medium-chain acyl-CoA dehydrogenase

Biochemistry ◽  
1987 ◽  
Vol 26 (12) ◽  
pp. 3704-3710 ◽  
Author(s):  
Patricia J. Powell ◽  
Sze Mei Lau ◽  
David Killian ◽  
Colin Thorpe
Keyword(s):  
Coenzyme A ◽  
Medium Chain ◽  
Pig Kidney ◽  
Chain Acyl ◽  
Acyl Coenzyme A

A fatal neonatal case of medium-chain acyl-coenzyme a dehydrogenase deficiency with homozygous A→G985 transition

1992 ◽  
Vol 121 (6) ◽  
pp. 965-968 ◽  
Author(s):  
Kin-Chuen Leung ◽  
Judith W. Hammond ◽  
Shilpi Chabra ◽  
Kevin H. Carpenter ◽  
Mary Potter ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Coenzyme A ◽  
Medium Chain ◽  
Chain Acyl ◽  
Acyl Coenzyme A
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