Utilization of shikimic acid for the formation of mycobactin S and salicyclic acid by Mycobacterium smegmatis

Biochemistry ◽  
1970 ◽  
Vol 9 (20) ◽  
pp. 3984-3987 ◽  
Author(s):  
Alan T. Hudson ◽  
Ronald Bentley
Keyword(s):  
Mycobacterium Smegmatis ◽  
Shikimic Acid ◽  
Salicyclic Acid ◽  
Mycobactin S

scholarly journals Isolation of mycobactins from various mycobacteria. The properties of mycobactins S and H

1969 ◽  
Vol 111 (5) ◽  
pp. 785-792 ◽  
Author(s):  
A. J. White ◽  
G. A. Snow
Keyword(s):  
Mycobacterium Smegmatis ◽  
Chemical Structure ◽  
Methyl Groups ◽  
Acid Moiety ◽  
Extraction And Purification ◽  
Acid Fragment ◽  
Previous Assignment ◽  
Optical Configuration ◽  
Synthetic Media ◽  
Mycobactin S

Mycobactin S has been isolated from Mycobacterium smegmatis and from Mycobacterium sp. Olitzky & Gershon, strain 2, and mycobactin H from M. thermoresistible; all three organisms were grown on synthetic media of low iron content. These two mycobactins are mixtures of compounds having the same nucleus but differing in their fatty side chains. The nucleus of mycobactin S has a chemical structure identical with that of mycobactin T but differs in the optical configuration at the β-carbon atom of the hydroxy acid fragment; the configuration in mycobactin S is S whereas that in mycobactin T is R (the previous assignment of this configuration was incorrect). The cobactin fragment of mycobactin H is identical with that of mycobactin S, but the mycobactic acid moiety differs in having methyl groups at position 6 in the benzene ring and at position 5 in the oxazoline ring. The configurations of all the asymmetric centres have been established for both mycobactins. Improved and simplified methods for the extraction and purification of mycobactins are described.

The incorporation of shikimic acid into mycobactin S and salicylic acid by

1970 ◽  
Vol 11 (24) ◽  
pp. 2077-2080 ◽  
Author(s):  
A.T. Hudson ◽  
Ronald Bentley
Keyword(s):  
Salicylic Acid ◽  
Shikimic Acid ◽  
Mycobactin S

scholarly journals Properties of a Trehalose Phosphate Synthetase from Mycobacterium smegmatis

1971 ◽  
Vol 246 (14) ◽  
pp. 4567-4579
Author(s):  
David Lapp ◽  
Betty W. Patterson ◽  
A.D. Elbein
Keyword(s):  
Mycobacterium Smegmatis
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