Mode of interaction of β-hydroxydecanoyl thioester dehydrase with allenic acid derivatives

Masuo Morisaki; Konrad Bloch

doi:10.1021/bi00753a001

Mode of interaction of β-hydroxydecanoyl thioester dehydrase with allenic acid derivatives

Biochemistry ◽

10.1021/bi00753a001 ◽

1972 ◽

Vol 11 (3) ◽

pp. 309-314 ◽

Cited By ~ 37

Author(s):

Masuo Morisaki ◽

Konrad Bloch

Keyword(s):

Allenic Acid

Download Full-text

Cycloadditionen, XX Thermisch induzierte intramolekulare Reaktionen bei 2-Methyl-2,3-butadienamiden / Cycloadditions, XX Thermally Induced Intramolecular Reactions of 2-Methyl-2,3-butadienamides

Zeitschrift für Naturforschung B ◽

10.1515/znb-1992-1224 ◽

1992 ◽

Vol 47 (12) ◽

pp. 1785-1794 ◽

Cited By ~ 9

Author(s):

Gerhard Himbert ◽

Hans-Jürgen Schlindwein

Keyword(s):

Double Bond ◽

Alder Reaction ◽

Diels Alder ◽

Secondary Amines ◽

Thermally Induced ◽

Methyl Group ◽

Diels Alder Reaction ◽

Intramolecular Reactions ◽

Derivatives Of ◽

Allenic Acid

The 2-methyl-2,3-butadienamides 4a—m are directly synthesized by the reaction of the corresponding allenic acid chloride 2 with the secondary amines 3. At heating, 4a—j undergo the intramolecular Diels-Alder reaction, by using their ω-standing double bond and the π-system of the directly bonded phenyl groups or of the “methylenic” bonded arenes or furans. Thereby the tricycles 6a—g (bearing five-membered lactam moreties) and/or the tricycles 7-9 (bearing six-membered lactam moreties) are formed. The influence of the geminai methyl group on the chemoselectivity and on the velocity of the IMDA reactions is investigated. The N-allyl derivatives of 4 (s. 41 and m) form the bicycles 10 by intramolecular [2+2]-Cycloaddition.

Download Full-text

Review: Pharmacological Activity, Chemical Composition and Medical Importance of Leonotis nepetifolia R.Br.

Journal of Complementary and Alternative Medical Research ◽

10.9734/jocamr/2021/v15i430275 ◽

2021 ◽

pp. 29-43

Author(s):

Pranjal C. Tidke ◽

Nikhita Chambhare ◽

Milind J. Umekar ◽

R. T. Lohiya

Keyword(s):

Biological Activities ◽

Physiological Effects ◽

Huge Number ◽

Pharmacological Activities ◽

Important Species ◽

Medicinal Uses ◽

The World ◽

History Of ◽

Medical Importance ◽

Allenic Acid

India is perhaps the most unique country in the world, with the richest tradition of indigenous and health care medical practices. Most of these practices are unique and known to very few individuals or communities. Leonotis nepetifolia Family (Lamiaceae) commonly known as ‘Klip dagga’ which has a long history of several traditional medicinal uses in many countries in the world. A huge number of phytoconstituents have been reported from the plant are allenic acid, iridoids, glycosides, terpenoids, and many more. This plant exhibited various biological activities and has been attributed to a variety of physiological effects like antifungal, antidiabetic, anxiolytic, arthritic, and many more activities. This literature review presents important species covering phytochemistry and pharmacological activities aspects systematically.

Download Full-text