Nucleoside phosphonic acids. V. Inhibition of micrococcal nuclease with 5'-deoxythymidine-5'-phosphonic acid containing oligomers

Biochemistry ◽  
1972 ◽  
Vol 11 (1) ◽  
pp. 9-12 ◽  
Author(s):  
D. H. Rammler ◽  
A. Bagdasarian ◽  
F. Morris
Keyword(s):  
Phosphonic Acid ◽  
Micrococcal Nuclease ◽  
Phosphonic Acids

scholarly journals A Sustainable Improvement of ω-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones

Organics ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 107-117
Author(s):  
Mattia Forchetta ◽  
Valeria Conte ◽  
Giulia Fiorani ◽  
Pierluca Galloni ◽  
Federica Sabuzi
Keyword(s):  
Metal Oxides ◽  
Phosphonic Acid ◽  
Organic Molecules ◽  
Building Blocks ◽  
Reaction Conditions ◽  
Phosphonic Acids ◽  
Sustainable Improvement ◽  
Phosphonate Esters ◽  
First Time ◽  
Complex Organic

Owing to the attractiveness of organic phosphonic acids and esters in the pharmacological field and in the functionalization of conductive metal-oxides, the research of effective synthetic protocols is pivotal. Among the others, ω-bromoalkylphosphonates are gaining particular attention because they are useful building blocks for the tailored functionalization of complex organic molecules. Hence, in this work, the optimization of Michaelis–Arbuzov reaction conditions for ω-bromoalkylphosphonates has been performed, to improve process sustainability while maintaining good yields. Synthesized ω-bromoalkylphosphonates have been successfully adopted for the synthesis of new KuQuinone phosphonate esters and, by hydrolysis, phosphonic acid KuQuinone derivatives have been obtained for the first time. Considering the high affinity with metal-oxides, KuQuinones bearing phosphonic acid terminal groups are promising candidates for biomedical and photo(electro)chemical applications.

PHOSPHONIC ACID MONOLAYERS FOR CORROSION PROTECTION OF COPPER: EQCM AND EIS INVESTIGATIONS

2019 ◽  
Vol 27 (06) ◽  
pp. 1950166
Author(s):  
AYSEL YURT ◽  
ESRA SOLMAZ
Keyword(s):  
Molecular Structure ◽  
Corrosion Protection ◽  
Phosphonic Acid ◽  
Quantum Chemical ◽  
Electrochemical Impedance ◽  
Film Formation ◽  
Copper Surface ◽  
Chemical Mechanism ◽  
Frequency Change ◽  
Phosphonic Acids

Preparation, characterization and application of protective phosphonic acid monolayers formed by 1-Aminohexyl phosphonic acid (AHP), 1,4-butanediphosphonic acid (BDPA), 1-amino-1,3-dimethylbutyl phosphonic acid (ADBP) on copper surface as anticorrosive self-assembled molecular monolayers (SAMs) have been investigated by atomic force microscopy (AFM) analysis, electrochemical impedance spectroscopy (EIS) and in situ electrochemical quartz crystal microbalance (EQCM) techniques. Film formation and growth were monitored by EQCM and the step-by-step construction of monolayer was investigated through measurement of the frequency change, which corresponds to mass change due to the adsorption of molecules. Observed increase in electrode mass suggests that SAMs formed on copper surface by the adsorption of phosphonic acids. Results clearly demonstrate that adsorbed amounts of phosphonic acids were strongly influenced by immersion time and molecular structure. Quantum chemical calculations were performed by semi-empirical PM6 method, in order to explain the relationship between molecular structure and adsorption mechanism. Quantum chemical parameters of phosphonic acids propound that adsorption of molecules on copper surface has a chemical mechanism. Corrosion protection ability of SAMs against the acidic corrosion of copper has been evaluated in 0.1[Formula: see text]M H2SO4 solution. It was found that phosphonic acid SAMs act as protective barrier and the protection efficiencies increased in the following order: [Formula: see text].

scholarly journals Phosphonic acid: preparation and applications

2017 ◽  
Vol 13 ◽  
pp. 2186-2213 ◽  
Author(s):  
Charlotte M Sevrain ◽  
Mathieu Berchel ◽  
Hélène Couthon ◽  
Paul-Alain Jaffrès
Keyword(s):  
Phosphonic Acid ◽  
Functional Group ◽  
Phosphinic Acid ◽  
Phosphorous Acid ◽  
Direct Methods ◽  
Phosphonic Acids ◽  
Research Fields ◽  
Dialkyl Phosphonates ◽  
Review Reports ◽  
Acid Functional Group

The phosphonic acid functional group, which is characterized by a phosphorus atom bonded to three oxygen atoms (two hydroxy groups and one P=O double bond) and one carbon atom, is employed for many applications due to its structural analogy with the phosphate moiety or to its coordination or supramolecular properties. Phosphonic acids were used for their bioactive properties (drug, pro-drug), for bone targeting, for the design of supramolecular or hybrid materials, for the functionalization of surfaces, for analytical purposes, for medical imaging or as phosphoantigen. These applications are covering a large panel of research fields including chemistry, biology and physics thus making the synthesis of phosphonic acids a determinant question for numerous research projects. This review gives, first, an overview of the different fields of application of phosphonic acids that are illustrated with studies mainly selected over the last 20 years. Further, this review reports the different methods that can be used for the synthesis of phosphonic acids from dialkyl or diaryl phosphonate, from dichlorophosphine or dichlorophosphine oxide, from phosphonodiamide, or by oxidation of phosphinic acid. Direct methods that make use of phosphorous acid (H3PO3) and that produce a phosphonic acid functional group simultaneously to the formation of the P–C bond, are also surveyed. Among all these methods, the dealkylation of dialkyl phosphonates under either acidic conditions (HCl) or using the McKenna procedure (a two-step reaction that makes use of bromotrimethylsilane followed by methanolysis) constitute the best methods to prepare phosphonic acids.

scholarly journals Surface Modification of SnO2with Phosphonic Acids

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Ramona Gheonea ◽  
Carmen Mak ◽  
Eleonora Cornelia Crasmareanu ◽  
Vasile Simulescu ◽  
Nicoleta Plesu ◽  
...  
Keyword(s):  
Surface Modification ◽  
Phosphonic Acid ◽  
Raw Materials ◽  
Optical Quality ◽  
Synthetic Approach ◽  
Phosphonic Acids ◽  
Molar Ratios ◽  
Long Time ◽  
Ft Ir ◽  
Synthesized Materials

The aim of the present work was the study of phosphonic acids grafting on the surface of SnO2at different molar ratios. In this paper we describe the functionalization of SnO2surfaces with phosphonic acids RPO(OH)2. The surface modification process was achieved by using phenyl-phosphonic acid (PPA) and vinyl-phosphonic acid (VPA). The synthesized materials were investigated by using FT-IR, TGA (in air and in nitrogen), EDX, ESEM, and TEM methods. This synthetic approach has many advantages: films with optical quality and controlled thickness can be obtained using low temperatures and cheap raw materials, by using “green chemistry” synthetic routes. The hybrid materials have structures diversity and fascinating applications, attracting attention for a long time, due to their potential.

ChemInform Abstract: AMINO PHOSPHONIC ACIDS. IV. NEW SYNTHESIS OF AMINO PHOSPHONIC ACID MONOESTERS

1976 ◽  
Vol 7 (12) ◽  
pp. no-no
Author(s):  
CZESLAW WASIELEWSKI ◽  
MARIA HOFFMANN ◽  
EWA WITKOWSKA
Keyword(s):  
Phosphonic Acid ◽  
Phosphonic Acids ◽  
New Synthesis

scholarly journals Phosphonic Acid Anhydrides [RPO2]n: Oligomerization and Structure

1995 ◽  
Vol 50 (6) ◽  
pp. 855-858 ◽  
Author(s):  
Stefan Fuchs ◽  
Hubert Schmidbaur
Keyword(s):  
General Formula ◽  
Phosphonic Acid ◽  
Nmr Spectra ◽  
Mass Spectrometric ◽  
Phosphonic Acids ◽  
Mass Spectrometric Data ◽  
Spectrometric Data ◽  
Acid Anhydrides

The phosphonic acid anhydrides of the general formula [RPO2]n have been prepared with R = Me, Et, i-Pr, t-Bu, and Ph from the corresponding phosphonic acids and their chlorides and esters. Mass spectrometric data indicate that the trimers are the dominant oligomers for all five systems. According to their NMR spectra, the methyl and t-butyl compounds have a symmetrical (C3v) structure with equivalent RP groups, while the ethyl, i-propyl and phenyl homologues have the Cs structure with non-equivalent PR groups in the ratio 1:2.

Synthesis of novel porphyrin and chlorin phosphonic acids and their immobilization on metal oxides

2011 ◽  
Vol 15 (09n10) ◽  
pp. 1070-1077 ◽  
Author(s):  
Martin Erbacher ◽  
Franz-Peter Montforts
Keyword(s):  
Metal Oxides ◽  
Phosphonic Acid ◽  
Self Assembled Monolayers ◽  
Phosphonic Acids ◽  
Amide Coupling ◽  
Vis Spectroscopy ◽  
Assembled Monolayers ◽  
Phosphonic Acid Groups ◽  
Hemin Chloride ◽  
Blood Pigment

In this study an easy and flexible access to porphyrin and chlorin phosphonic acids is presented. Novel types of phosphonic acid terminated porphyrins and chlorins were synthesized starting from commercially available red blood pigment hemin chloride. Phosphonic acid groups were linked to the porphyrinoids by amide coupling via appropriate spacer moieties. Self-assembled monolayers of the synthesized phosphonates on mesoporous TiO2 electrodes of approximately 3 μm thickness were formed. Surface concentrations in a range of 1 to 4 × 10-8 mol.cm-2 could be determined by UV-vis spectroscopy.

Organophosphorus Compounds. II. Preparation of Phosphonic Acid Esters using the Dicyclohexylcarbodiimide Reagent

1963 ◽  
Vol 16 (4) ◽  
pp. 609 ◽  
Author(s):  
JA Maynard ◽  
JM Swan
Keyword(s):  
Phosphonic Acid ◽  
Organophosphorus Compounds ◽  
Phosphonic Acids ◽  
Pyridine Solution ◽  
Acid Esters

Mono- and diesters of phosphonic acids are conveniently prepared by reaction of a phosphonic acid with appropriate quantities of NN'-dicyclohexylcarbodiimide and an alcohol or phenol in pyridine solution.

ChemInform Abstract: Synthesis of trans-1,2-Difluoroethenediylbis(phosphonic acid) and Other Unsaturated Phosphonic Acids.

ChemInform ◽  
1990 ◽  
Vol 21 (30) ◽  
Author(s):  
D. SU ◽  
C.-Y. GUO ◽  
R. D. WILLETT ◽  
B. SCOTT ◽  
R. L. KIRCHMEIER ◽  
...  
Keyword(s):  
Phosphonic Acid ◽  
Phosphonic Acids
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