Carbonic anhydrase catalyzed hydrolysis and decarboxylation. Kinetic studies of enzyme-catalyzed decomposition of mono- and disubstituted derivatives of carbonic acid

Biochemistry ◽  
1974 ◽  
Vol 13 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Y. Pocker ◽  
L. J. Guilbert
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Acid ◽  
Kinetic Studies ◽  
Derivatives Of

Preliminary Note on Dietthio and Diethylsulphone derivatives of Succinic Acid

1897 ◽  
Vol 21 ◽  
pp. 156-159
Author(s):  
Crum Brown ◽  
R. Fairbairn
Keyword(s):  
Succinic Acid ◽  
Calcium Chloride ◽  
Boiling Point ◽  
Carbonic Acid ◽  
Steam Bath ◽  
Sodium Bromide ◽  
Absolute Alcohol ◽  
Preliminary Note ◽  
Aqueous Layer ◽  
Derivatives Of

Sodium mercaptide and dibromosuccinic ether, in the proportion of two molecules of the former to one of the latter, were dissolved separately in absolute alcohol, and slowly mixed. A considerable evolution of heat took place, while sodium bromide separated out. The flask was then digested for some hours on the steam-bath. The alcohol was subsequently distilled off, and the residue, on cooling, was treated with water. An oil separated out. This oil was collected by means of a separating funnel, and the aqueous layer several times extracted with ether. The oil and the ethereal extracts were added together and dried over calcium chloride. Next morning the ether was distilled off at the ordinary pressure. The remainder was distilled in vacuo. Between 50° and 60° a few drops came over, which proved to be ethyldisulphide.The remainder came over between 150° and 170°.This latter fraction was redistilled, and a portion of it used for analysis. The boiling point at 20 mm. pressure was 160°.Combustion of dietthiosuccinic ether.Weight of substance taken = ·2477 gram.Weight of carbonic acid obtained = ·4476 gram.Weight of water obtained = ·1702 gram.

scholarly journals Kinetic studies of pea carbonic anhydrase

1993 ◽  
Vol 218 (2) ◽  
pp. 439-446 ◽  
Author(s):  
Inga-Maj JOHANSSON ◽  
Cecilia FORSMAN
Keyword(s):  
Carbonic Anhydrase ◽  
Kinetic Studies

Reaktionsverhalten von β-Oxo-carbonsäurederivaten der Anthracenreihe bei der Synthese von Pyrazolen / On the Reaction Behavior of ß-Oxo Carbonic Acid Derivatives of the Anthracene Series in Pyrazole Synthesis

1999 ◽  
Vol 54 (9) ◽  
pp. 1133-1137
Author(s):  
Astrid Knieß ◽  
Margit Gruner ◽  
Roland Mayer
Keyword(s):  
Carbonyl Group ◽  
Carbonic Acid ◽  
Ester Group ◽  
Reaction Behavior ◽  
Anthracene Derivatives ◽  
Sterical Hindrance ◽  
Derivatives Of

ß-Oxo-1 and 9-anthracenepropionate (6 and 7) reacts with DMF-acetale to enaminones 10 and 11. The reaction of 2-(dimethylamino)methylen-substituted ß-oxo-1 -anthracenepropionate (10) with hydrazines yields 5-(l-anthracenyl)-pyrazol-4-carboxylates (13). In contrast, the cyclocondensation of 3-(9-anthracenyl)-2-(dimethylamino)methylen-3-oxo-propionate (11) with hydrazine hydrochlorides gives 4-(9-anthracenoyl)-5-hydroxy-pyrazoles (14). This is caused by the sterical hindrance of the carbonyl group of the anthracene derivatives in position 9; thus, the cyclocondensation proceeds via reaction of the ester group of the enaminone 11.

Sign in / Sign up

Export Citation Format

Share Document