Lipoprotein lipase. Mechanism of formation of triglyceride-rich remnant particles from very low density lipoproteins and chylomicrons

Biochemistry ◽  
1975 ◽  
Vol 14 (11) ◽  
pp. 2288-2293 ◽  
Author(s):  
J. M. Higgins ◽  
C. J. Fielding
Keyword(s):  
Lipoprotein Lipase ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Mechanism Of Formation ◽  
Very Low Density Lipoproteins

scholarly journals Decreased Susceptibility of Glycated Very Low Density Lipoproteins to Lipoprotein Lipase in vitro and Prevention by Glutathione

1994 ◽  
Vol 1 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Shuichi Saheki ◽  
Kohji Shishino ◽  
Yasuo Hitsumoto ◽  
Mitsuharu Murase ◽  
Nozomu Takeuchi ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins

79 Lipoprotein lipase is required for the binding of very low density lipoproteins to heparan sulphate proteoglycans

1997 ◽  
Vol 130 ◽  
pp. S21
Author(s):  
Femke de Beer ◽  
Frits H.A.F. de Man ◽  
Augustinus H.M. Smelt ◽  
Arnoud van der Laarse ◽  
Louis M. Havekes
Keyword(s):  
Lipoprotein Lipase ◽  
Heparan Sulphate ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Heparan Sulphate Proteoglycans

scholarly journals Hepatic lipase function and the accumulation of β-very-low-density lipoproteins in the plasma of cholesterol-fed rabbits

1993 ◽  
Vol 293 (3) ◽  
pp. 745-750 ◽  
Author(s):  
S Chang ◽  
J Borensztajn
Keyword(s):  
Lipoprotein Lipase ◽  
Hepatic Lipase ◽  
Low Density Lipoproteins ◽  
High Cholesterol Diet ◽  
Low Density ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Very Low Density Lipoproteins

The accumulation of cholesterol-rich beta-very-low-density lipoproteins (beta-VLDL) in the plasma of rabbits fed on a high-fat high-cholesterol diet is due to a defect in the clearance of these lipoprotein remnants from circulation by the liver. In view of the evidence that hepatic lipase participates in the process of rapid removal of remnants from circulation, and considering that rabbits are naturally deficient in hepatic lipase, we examined whether this defect in the clearance of beta-VLDL could be reversed by exogenous hepatic lipase. We report that treatment in vitro of [3H]cholesterol-labelled beta-VLDL, or rat chylomicrons, with hepatic lipase resulted in the formation of particles that were rapidly cleared from circulation by the liver when injected intravenously into hypercholesterolaemic rabbits. These results are consistent with the notion that, in addition to the well-established requirement for lipoprotein lipase activity, the generation of remnants capable of being efficiently taken up by the liver also requires the action of hepatic lipase. Lipoprotein lipase acts on triacylglycerol-rich lipoproteins to transform them into particles (remnants) which bind to the surface of liver cells, where they become accessible to hepatic lipase. Hepatocyte endocytosis of these remnants occurs only after further modification by hepatic lipase. According to this scheme, the results presented suggest that the accumulation of beta-VLDL in the circulation of rabbits fed on a high-fat high-cholesterol diet is the result of the saturation of the available hepatic lipase by abnormally high levels of lipoprotein-lipase-generated chylomicron remnants.

Effects of substitutions of glycine and asparagine for serine132 on activity and binding of human lipoprotein lipase to very low density lipoproteins

FEBS Letters ◽  
1992 ◽  
Vol 298 (1) ◽  
pp. 36-38 ◽  
Author(s):  
Jun Tashiro ◽  
Junji Kobayashi ◽  
Kohji Shirai ◽  
Yasushi Saito ◽  
Isamu Fukamachi ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins
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