Physical properties of some ribosomal proteins in solution and evidence for molecular interactions between isolated ribosomal proteins

Biochemistry ◽  
1975 ◽  
Vol 14 (5) ◽  
pp. 1079-1087 ◽  
Author(s):  
Michael F. Rohde ◽  
Sally O'Brien ◽  
Susan Cooper ◽  
Kirk C. Aune
Macromol ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 155-172
Author(s):  
Aristeidis Papagiannopoulos

Polyelectrolytes have been at the center of interdisciplinary research for many decades. In the field of polymer science and soft matter, they have provided the dimensions of electrostatic interactions, which opens a vast variety of opportunities for new physical properties and applications. In biological matter, polyelectrolytes are present in many forms, from extracellular polysaccharides to complex DNA molecules and proteins. This review discusses the recent research on polyelectrolytes covering the fundamental level of their conformations and nanostructures, their molecular interactions with materials that have close relevance to bioapplications and their applications in the biomedical field. This approach is motivated by the fact that the polyelectrolyte research is constantly active in all the aforementioned levels and continually affects many critical scientific areas.


Author(s):  
Jane S. Murray ◽  
Peter Politzer

The quest for improved methods for elucidating and predicting the reactive behavior of molecules and other chemical species is a continuing theme of theoretical chemistry. This has led to the introduction of a variety of indices of reactivity; some are rather arbitrary, while others are more or less directly related to real physical properties. They have been designed and are used to provide some quantitative measure of the chemical activities of various sites and/or regions of the molecule. In this chapter our focus is on one of these indices, the electrostatic potential V(r) that is created in the space around a molecule by its nuclei and electrons. V(r) can be computed rigorously, given the electronic density function ρ(r), by Eq. (3.1).


2014 ◽  
Vol 169 ◽  
pp. 195-207 ◽  
Author(s):  
Chad R. Bernier ◽  
Anton S. Petrov ◽  
Chris C. Waterbury ◽  
James Jett ◽  
Fengbo Li ◽  
...  

RiboVision is a visualization and analysis tool for the simultaneous display of multiple layers of diverse information on primary (1D), secondary (2D), and three-dimensional (3D) structures of ribosomes. The ribosome is a macromolecular complex containing ribosomal RNA and ribosomal proteins and is a key component of life responsible for the synthesis of proteins in all living organisms. RiboVision is intended for rapid retrieval, analysis, filtering, and display of a variety of ribosomal data. Preloaded information includes 1D, 2D, and 3D structures augmented by base-pairing, base-stacking, and other molecular interactions. RiboVision is preloaded with rRNA secondary structures, rRNA domains and helical structures, phylogeny, crystallographic thermal factors,etc.RiboVision contains structures of ribosomal proteins and a database of their molecular interactions with rRNA. RiboVision contains preloaded structures and data for two bacterial ribosomes (Thermus thermophilusandEscherichia coli), one archaeal ribosome (Haloarcula marismortui), and three eukaryotic ribosomes (Saccharomyces cerevisiae,Drosophila melanogaster, andHomo sapiens). RiboVision revealed several major discrepancies between the 2D and 3D structures of the rRNAs of the small and large subunits (SSU and LSU). Revised structures mapped with a variety of data are available in RiboVision as well as in a public gallery (http://apollo.chemistry.gatech.edu/RibosomeGallery). RiboVision is designed to allow users to distill complex data quickly and to easily generate publication-quality images of data mapped onto secondary structures. Users can readily import and analyze their own data in the context of other work. This package allows users to import and map data from CSV files directly onto 1D, 2D, and 3D levels of structure. RiboVision has features in rough analogy with web-based map services capable of seamlessly switching the type of data displayed and the resolution or magnification of the display. RiboVision is available at http://apollo.chemistry.gatech.edu/RiboVision.


FEBS Letters ◽  
1983 ◽  
Vol 157 (1) ◽  
pp. 85-90 ◽  
Author(s):  
L.G. Tumanova ◽  
G.M. Gongadze ◽  
S.Yu. Venyaminov ◽  
A.T. Gudkov ◽  
V.N. Bushuev

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