Energetics of triosephosphate isomerase: the nature of the proton transfer between the catalytic base and solvent water

L. Mark Fisher; W. John Albery; Jeremy R. Knowles

doi:10.1021/bi00670a030

Energetics of triosephosphate isomerase: the nature of the proton transfer between the catalytic base and solvent water

Biochemistry ◽

10.1021/bi00670a030 ◽

1976 ◽

Vol 15 (25) ◽

pp. 5621-5626 ◽

Cited By ~ 18

Author(s):

L. Mark Fisher ◽

W. John Albery ◽

Jeremy R. Knowles

Keyword(s):

Proton Transfer ◽

Triosephosphate Isomerase ◽

Solvent Water

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Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O

Organic & Biomolecular Chemistry ◽

10.1039/b714304d ◽

2008 ◽

Vol 6 (2) ◽

pp. 391-396 ◽

Cited By ~ 9

Author(s):

AnnMarie C. O'Donoghue ◽

Tina L. Amyes ◽

John P. Richard

Keyword(s):

Carboxylic Acid ◽

Proton Transfer ◽

Triosephosphate Isomerase ◽

Side Chain

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Nuclear quantum effects on an enzyme-catalyzed reaction with reaction path potential: Proton transfer in triosephosphate isomerase

The Journal of Chemical Physics ◽

10.1063/1.2181145 ◽

2006 ◽

Vol 124 (12) ◽

pp. 124516 ◽

Cited By ~ 40

Author(s):

Mingliang Wang ◽

Zhenyu Lu ◽

Weitao Yang

Keyword(s):

Proton Transfer ◽

Triosephosphate Isomerase ◽

Reaction Path ◽

Quantum Effects ◽

Nuclear Quantum Effects

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NMR Studies on Proton Transfer between Hydration and Solvent Water Molecules in Aqueous Solution of AlCl3

Journal of the Physical Society of Japan ◽

10.1143/jpsj.24.657 ◽

1968 ◽

Vol 24 (3) ◽

pp. 657-658 ◽

Cited By ~ 8

Author(s):

Akira Takahashi

Keyword(s):

Aqueous Solution ◽

Proton Transfer ◽

Water Molecules ◽

Nmr Studies ◽

Solvent Water

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A position dependent friction model for solution reactions in the high friction regime: Proton transfer in triosephosphate isomerase (TIM)

The Journal of Chemical Physics ◽

10.1063/1.472889 ◽

1996 ◽

Vol 105 (24) ◽

pp. 10812-10818 ◽

Cited By ~ 28

Author(s):

Eyal Neria ◽

Martin Karplus

Keyword(s):

Proton Transfer ◽

Triosephosphate Isomerase ◽

Friction Model ◽

Friction Regime

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The nature of the proton transfer from an acid group at the active site of an enzyme, to solvent water. The extent of 2H and 3H transfer in the reaction catalysed by triose phosphate isomerase

Faraday Symposia of the Chemical Society ◽

10.1039/fs9751000154 ◽

1975 ◽

Vol 10 ◽

pp. 154 ◽

Cited By ~ 3

Author(s):

L. Mark Fisher ◽

W. John Albery ◽

Jeremy R. Knowles

Keyword(s):

Proton Transfer ◽

Active Site ◽

Acid Group ◽

Triose Phosphate Isomerase ◽

Triose Phosphate ◽

Solvent Water

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Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: New insight in the proton transfer reaction mechanism

Proteins Structure Function and Bioinformatics ◽

10.1002/prot.22701 ◽

2010 ◽

Vol 78 (8) ◽

pp. 1878-1888 ◽

Cited By ~ 14

Author(s):

Markus Alahuhta ◽

Rik K. Wierenga

Keyword(s):

Reaction Mechanism ◽

Proton Transfer ◽

Transfer Reaction ◽

Triosephosphate Isomerase ◽

Proton Transfer Reaction ◽

Atomic Resolution ◽

Reaction Intermediate

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The intramolecular mechanism for the second proton transfer in triosephosphate isomerase (TIM): A QM/FE approach

Journal of Computational Chemistry ◽

10.1002/jcc.10153 ◽

2002 ◽

Vol 24 (1) ◽

pp. 46-56 ◽

Cited By ~ 10

Author(s):

Giuliano Alagona ◽

Caterina Ghio ◽

Peter A. Kollman

Keyword(s):

Proton Transfer ◽

Triosephosphate Isomerase ◽

Intramolecular Mechanism

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Transmission coefficient calculation for proton transfer in triosephosphate isomerase based on the reaction path potential method

The Journal of Chemical Physics ◽

10.1063/1.1757437 ◽

2004 ◽

Vol 121 (1) ◽

pp. 101 ◽

Cited By ~ 13

Author(s):

Mingliang Wang ◽

Zhenyu Lu ◽

Weitao Yang

Keyword(s):

Proton Transfer ◽

Transmission Coefficient ◽

Triosephosphate Isomerase ◽

Reaction Path ◽

Potential Method

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ChemInform Abstract: LACTIM/LACTAM TAUTOMERIC INTERCONVERSION MECHANISM IN WATER/POLAR APROTIC SOLVENT WATER SYSTEMS. 2. HYDRATION OF 2-HYDROXYPYRIDINES. EVIDENCE FOR A BIFUNCTIONAL WATER-CATALYZED PROTON TRANSFER

Chemischer Informationsdienst ◽

10.1002/chin.197932108 ◽

1979 ◽

Vol 10 (32) ◽

Author(s):

O. BENSAUDE ◽

M. CHEVRIER ◽

J.-E. DUBOIS

Keyword(s):

Proton Transfer ◽

Aprotic Solvent ◽

Water Systems ◽

Solvent Water ◽

Polar Aprotic Solvent

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A Paradigm for Enzyme-Catalyzed Proton Transfer at Carbon: Triosephosphate Isomerase

Biochemistry ◽

10.1021/bi300195b ◽

2012 ◽

Vol 51 (13) ◽

pp. 2652-2661 ◽

Cited By ~ 56

Author(s):

John P. Richard

Keyword(s):

Proton Transfer ◽

Triosephosphate Isomerase

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