Fluorescent probes in model membranes I: anthroyl fatty acid derivatives in monolayers and liposomes of dipalmitoylphosphatidylcholine

Biochemistry ◽  
1977 ◽  
Vol 16 (24) ◽  
pp. 5386-5392 ◽  
Author(s):  
D. Allan Cadenhead ◽  
Benedikt M. J. Kellner ◽  
Kenneth Jacobson ◽  
Demetrios Papahadjopoulos
Keyword(s):  
Fatty Acid ◽  
Fluorescent Probes ◽  
Model Membranes ◽  
Fatty Acid Derivatives

scholarly journals Valorization of waste-cooking oil into sophorolipids and application of their methyl hydroxyl branched fatty acid derivatives to produce engineering bioplastics

2021 ◽  
Vol 124 ◽  
pp. 195-202
Author(s):  
Jeong-Hun Kim ◽  
Yu-Ri Oh ◽  
Juyoung Hwang ◽  
Jaeryeon Kang ◽  
Hyeri Kim ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Waste Cooking Oil ◽  
Cooking Oil ◽  
Fatty Acid Derivatives

Divinylcarbinol Desymmetrization Strategy: A Concise and Reliable Approach to Chiral Hydroxylated Fatty Acid Derivatives

2021 ◽  
Vol 86 (5) ◽  
pp. 3970-3980
Author(s):  
Kenji Sugimoto ◽  
Ami Kobayashi ◽  
Aki Kohyama ◽  
Haruka Sakai ◽  
Yuji Matsuya
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Derivatives

scholarly journals Investigation of the Membrane Fluidity Regulation of Fatty Acid Intracellular Distribution by Fluorescence Lifetime Imaging of Novel Polarity Sensitive Fluorescent Derivatives

2021 ◽  
Vol 22 (6) ◽  
pp. 3106
Author(s):  
Giada Bianchetti ◽  
Salome Azoulay-Ginsburg ◽  
Nimrod Yosef Keshet-Levy ◽  
Aviv Malka ◽  
Sofia Zilber ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acids ◽  
Membrane Fluidity ◽  
Fluorescence Lifetime ◽  
Intracellular Distribution ◽  
Fluorescence Lifetime Imaging ◽  
Lifetime Imaging ◽  
Fatty Acid Derivatives ◽  
Polarity Sensitive

Free fatty acids are essential structural components of the cell, and their intracellular distribution and effects on membrane organelles have crucial roles in regulating the metabolism, development, and cell cycle of most cell types. Here we engineered novel fluorescent, polarity-sensitive fatty acid derivatives, with the fatty acid aliphatic chain of increasing length (from 12 to 18 carbons). As in the laurdan probe, the lipophilic acyl tail is connected to the environmentally sensitive dimethylaminonaphthalene moiety. The fluorescence lifetime imaging analysis allowed us to monitor the intracellular distribution of the free fatty acids within the cell, and to simultaneously examine how the fluidity and the microviscosity of the membrane environment influence their localization. Each of these probes can thus be used to investigate the membrane fluidity regulation of the correspondent fatty acid intracellular distribution. We observed that, in PC-12 cells, fluorescent sensitive fatty acid derivatives with increased chain length compartmentalize more preferentially in the fluid regions, characterized by a low microviscosity. Moreover, fatty acid derivatives with the longest chain compartmentalize in lipid droplets and lysosomes with characteristic lifetimes, thus making these probes a promising tool for monitoring lipophagy and related events.

Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer’s agent

2014 ◽  
Vol 24 (2) ◽  
pp. 604-608 ◽  
Author(s):  
Hong-Yan Zhang ◽  
Yu-ichiro Yamakawa ◽  
Yuji Matsuya ◽  
Naoki Toyooka ◽  
Chihiro Tohda ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Fatty Acid Derivatives ◽  
Long Chain
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