Amino acid sequence studies on the α chain of human fibrinogen. Covalent structure of the α-chain portion of fragment D

Biochemistry ◽  
1977 ◽  
Vol 16 (8) ◽  
pp. 1710-1715 ◽  
Author(s):  
R. F. Doolittle ◽  
K. G. Cassman ◽  
B. A. Cottrell ◽  
S. J. Friezner ◽  
T. Takagi
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Human Fibrinogen ◽  
Covalent Structure ◽  
Α Chain

Preliminary report on the amino acid sequence of the α-chain of human fibrinogen

1979 ◽  
Vol 14 (4-5) ◽  
pp. 787-792 ◽  
Author(s):  
R.F. Doolittle ◽  
B.A. Cottrell ◽  
D. Strong ◽  
K.W.K. Watt
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Preliminary Report ◽  
Human Fibrinogen ◽  
Α Chain

Amino acid sequence studies on the α chain of human fibrinogen. Characterization of 11 cyanogen bromide fragments

Biochemistry ◽  
1977 ◽  
Vol 16 (8) ◽  
pp. 1703-1709 ◽  
Author(s):  
R. F. Doolittle ◽  
K. G. Cassman ◽  
B. A. Cottrell ◽  
S. J. Friezner ◽  
J. T. Hucko ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Cyanogen Bromide ◽  
Human Fibrinogen ◽  
Α Chain

The amino acid sequence of the α-chain of human fibrinogen

Nature ◽  
1979 ◽  
Vol 280 (5722) ◽  
pp. 464-468 ◽  
Author(s):  
R. F. Doolittle ◽  
K. W. K. Watt ◽  
B. A. Cottrell ◽  
D. D. Strong ◽  
M. Riley
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Human Fibrinogen ◽  
Α Chain

Complete Covalent Structure of Human Platelet Factor 4

1979 ◽  
Vol 42 (05) ◽  
pp. 1652-1660 ◽  
Author(s):  
Francis J Morgan ◽  
Geoffrey S Begg ◽  
Colin N Chesterman
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Human Platelet ◽  
Platelet Factor 4 ◽  
Platelet Factor ◽  
Disulphide Bonds ◽  
Covalent Structure

SummaryThe amino acid sequence of the subunit of human platelet factor 4 has been determined. Human platelet factor 4 consists of identical subunits containing 70 amino acids, each with a molecular weight of 7,756. The molecule contains no methionine, phenylalanine or tryptophan. The proposed amino acid sequence of PF4 is: Glu-Ala-Glu-Glu-Asp-Gly-Asp-Leu-Gln-Cys-Leu-Cys-Val-Lys-Thr-Thr-Ser- Gln-Val-Arg-Pro-Arg-His-Ile-Thr-Ser-Leu-Glu-Val-Ile-Lys-Ala-Gly-Pro-His-Cys-Pro-Thr-Ala-Gin- Leu-Ile-Ala-Thr-Leu-Lys-Asn-Gly-Arg-Lys-Ile-Cys-Leu-Asp-Leu-Gln-Ala-Pro-Leu-Tyr-Lys-Lys- Ile-Ile-Lys-Lys-Leu-Leu-Glu-Ser. From consideration of the homology with p-thromboglobulin, disulphide bonds between residues 10 and 36 and between residues 12 and 52 can be inferred.

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