Ligand-induced changes in membrane-bound acetylcholine receptor observed by ethidium fluorescence. 1. Equilibrium studies

Biochemistry ◽  
1979 ◽  
Vol 18 (10) ◽  
pp. 1884-1890 ◽  
Author(s):  
Michael Schimerlik ◽  
Ulrich Quast ◽  
Michael A. Raftery
Keyword(s):  
Acetylcholine Receptor ◽  
Equilibrium Studies ◽  
Membrane Bound ◽  
Induced Changes

Allosteric interactions between the membrane-bound acetylcholine receptor and chemical mediators. Kinetic studies

Biochemistry ◽  
1977 ◽  
Vol 16 (4) ◽  
pp. 684-692 ◽  
Author(s):  
James E. Bulger ◽  
Juian-Juian L. Fu ◽  
Ellen F. Hindy ◽  
Richard L. Silberstein ◽  
George P. Hess
Keyword(s):  
Acetylcholine Receptor ◽  
Kinetic Studies ◽  
Allosteric Interactions ◽  
Membrane Bound ◽  
Chemical Mediators

Interactions of fluorescent cholinergic antagonists with the membrane-bound acetylcholine receptor

1980 ◽  
Vol 2 ◽  
pp. 257-267 ◽  
Author(s):  
Y.P. Tan ◽  
W. Stender ◽  
A.L. Harvey ◽  
B. Soria ◽  
F.J. Barrantes
Keyword(s):  
Acetylcholine Receptor ◽  
Cholinergic Antagonists ◽  
Membrane Bound

Ligand-induced conformation changes in Torpedo californica membrane-bound acetylcholine receptor

Biochemistry ◽  
1978 ◽  
Vol 17 (12) ◽  
pp. 2405-2414 ◽  
Author(s):  
U. Quast ◽  
M. Schimerlik ◽  
T. Lee ◽  
V. Witzemann ◽  
S. Blanchard ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Torpedo Californica ◽  
Conformation Changes ◽  
Membrane Bound

Nicotinic acetylcholine receptor (nACh-R) agonist-induced changes in brain monoamine turnover in mice

1997 ◽  
Vol 129 (3) ◽  
pp. 225-232 ◽  
Author(s):  
Yoshihiro Tani ◽  
Kyoshi Saito ◽  
Atsuko Tsuneyoshi ◽  
Masahiro Imoto ◽  
Tomochika Ohno
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Monoamine Turnover ◽  
Brain Monoamine ◽  
Induced Changes

scholarly journals PGE2-induced metalloproteinase-9 is essential for dendritic cell migration

Blood ◽  
2008 ◽  
Vol 111 (1) ◽  
pp. 260-270 ◽  
Author(s):  
Jui-Hung Yen ◽  
Tanzilya Khayrullina ◽  
Doina Ganea
Keyword(s):  
Lymph Nodes ◽  
Basement Membranes ◽  
Directional Migration ◽  
Dendritic Cell Migration ◽  
Membrane Bound ◽  
Induced Changes ◽  
Expression Program ◽  
Metalloproteinase 9 ◽  
Draining Lymph Nodes

Following antigen acquisition and maturation, dendritic cells (DCs) disengage from the extracellular matrix, cross basement membranes, and travel to draining lymph nodes to activate T cells. CCR7 expression is necessary but not sufficient for the directional migration of DCs. Prostaglandin E2 (PGE2), present in inflammatory sites, induces DC migration, presumably by enacting a migration-permissive gene expression program. Since regulation of DC migration is highly important for their use in vaccination and therapy, we examined the PGE2-induced changes in the expression of metalloproteinases (MMPs). Our results indicate that PGE2 significantly up-regulates MMP-9 expression, induces both secreted and membrane-bound MMP-9, and that in turn, DC-derived MMP-9 is essential for DC chemotaxis in response to the CCR7 ligand CCL19, Matrigel migration, and in vivo migration in both wild-type and MMP-9–deficient hosts. We conclude that DCs matured within inflammatory sites require both CCR7 and PGE2-induced MMP-9 for their directional migration to draining lymph nodes.

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