Role of 2',5'-oligo(adenylic acid) polymerase in the degradation of ribonucleic acid linked to double-stranded ribonucleic acid by extracts of interferon-treated cells

Biochemistry ◽  
1980 ◽  
Vol 19 (24) ◽  
pp. 5574-5579 ◽  
Author(s):  
Timothy W. Nilsen ◽  
Sanford G. Weissman ◽  
Corrado Baglioni
Keyword(s):  
Ribonucleic Acid ◽  
Adenylic Acid

scholarly journals Studies on the Role of Methylated Bases in the Biological Activity of Soluble Ribonucleic Acid

1964 ◽  
Vol 239 (9) ◽  
pp. 2918-2926
Author(s):  
Alan Peterkofsky ◽  
Celia Jesensky ◽  
Arthur Bank ◽  
Alan H. Mehler
Keyword(s):  
Biological Activity ◽  
Ribonucleic Acid

scholarly journals Role of conformational heterogeneity in ligand recognition by viral RNA molecules

2021 ◽  
Author(s):  
Lev Levintov ◽  
Harish Vashisth
Keyword(s):  
Conformational Changes ◽  
Ribonucleic Acid ◽  
Viral Rna ◽  
Ligand Recognition ◽  
Conformational Heterogeneity ◽  
Rna Molecules ◽  
Environmental Stimuli

Ribonucleic acid (RNA) molecules are known to undergo conformational changes in response to various environmental stimuli including temperature, pH, and ligands. In particular, viral RNA molecules are a key example...

Prebiotic studies on the interaction of zirconia nanoparticles and ribose nucleotides and their role in chemical evolution

2021 ◽  
Vol 20 (2) ◽  
pp. 142-149
Author(s):  
Avnish Kumar Arora ◽  
Pankaj Kumar
Keyword(s):  
Electron Microscopy ◽  
Metal Oxide ◽  
Metal Oxides ◽  
Chemical Evolution ◽  
Ribonucleic Acid ◽  
Zirconium Oxide ◽  
Origins Of Life ◽  
Neutral Ph ◽  
Interaction Studies

AbstractStudies on the interaction of biomolecules with inorganic compounds, mainly mineral surfaces, are of great concern in identifying their role in chemical evolution and origins of life. Metal oxides are the major constituents of earth and earth-like planets. Hence, studies on the interaction of biomolecules with these minerals are the point of concern for the study of the emergence of life on different planets. Zirconium oxide is one of the metal oxides present in earth's crust as it is a part of several types of rocks found in sandy areas such as beaches and riverbeds, e.g. pebbles of baddeleyite. Different metal oxides have been studied for their role in chemical evolution but no studies have been reported about the role of zirconium oxide in chemical evolution and origins of life. Therefore, studies were carried out on the interaction of ribonucleic acid constituents, 5′-CMP (cytidine monophosphate), 5′-UMP (uridine monophosphate), 5′-GMP (guanosine monophosphate) and 5′-AMP (adenosine monophosphate), with zirconium oxide. Synthesized zirconium oxide particles were characterized by using vibrating sample magnetometer, X-Ray Diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy. Zirconia particles were in the nanometre range, from 14 to 27 nm. The interaction of zirconium oxide with ribonucleic acid constituents was performed in the concentration range of 5 × 10−5–300 × 10−5 M. Interaction studies were carried out in three mediums; acidic (pH 4.0), neutral (pH 7.0) and basic (pH 9.0). At neutral pH, maximum interaction was observed. The interaction of zirconium oxide with 5′-UMP was 49.45% and with 5′-CMP 67.98%, while with others it was in between. Interaction studies were Langmurian in nature. Xm and KL values were calculated. Infrared spectral studies of ribonucleotides, metal oxide and ribonucleotide–metal oxide adducts were carried out to find out the interactive sites. It was observed that the nitrogen base and phosphate moiety of ribonucleotides interact with the positive charge surface of metal oxide. SEM was also carried out to study the adsorption. The results of the present study favour the important role of zirconium oxide in concentrating the organic molecules from their dilute aqueous solutions in primeval seas.

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