Kinetics of binding of [3H]acetylcholine and [3H]carbamoylcholine to Torpedo postsynaptic membranes: slow conformational transitions of the cholinergic receptor

Biochemistry ◽  
1980 ◽  
Vol 19 (23) ◽  
pp. 5344-5353 ◽  
Author(s):  
Norman D. Boyd ◽  
Jonathan B. Cohen
Keyword(s):  
Cholinergic Receptor ◽  
Conformational Transitions ◽  
Kinetics Of

Kinetics of thermally-induced conformational transitions in soybean protein films

Polymer ◽  
2010 ◽  
Vol 51 (11) ◽  
pp. 2410-2416 ◽  
Author(s):  
Kun Tian ◽  
David Porter ◽  
Jinrong Yao ◽  
Zhengzhong Shao ◽  
Xin Chen
Keyword(s):  
Soybean Protein ◽  
Conformational Transitions ◽  
Protein Films ◽  
Thermally Induced ◽  
Kinetics Of

scholarly journals Kinetics of Anesthetic-Induced Conformational Transitions in a Four-α-Helix Bundle Protein†

Biochemistry ◽  
2006 ◽  
Vol 45 (5) ◽  
pp. 1435-1441 ◽  
Author(s):  
Ken Solt ◽  
Jonas S. Johansson ◽  
Douglas E. Raines
Keyword(s):  
Conformational Transitions ◽  
Helix Bundle ◽  
Α Helix ◽  
Kinetics Of ◽  
Bundle Protein

Influence of intermolecular interaction on kinetics of conformational transitions in poly-m-phenyleneisophthalamide

1985 ◽  
Vol 43 (2) ◽  
pp. 891-895
Author(s):  
P. M. Pakhomov ◽  
I. I. Novak ◽  
M. V. Shablygin ◽  
V. E. Korsukov
Keyword(s):  
Intermolecular Interaction ◽  
Conformational Transitions ◽  
Kinetics Of

Kinetics of conformational transitions in chain molecules

1980 ◽  
Vol 72 (10) ◽  
pp. 5489-5500 ◽  
Author(s):  
Jeffrey Skolnick ◽  
Eugene Helfand
Keyword(s):  
Conformational Transitions ◽  
Chain Molecules ◽  
Kinetics Of

The influence of D2O, perchlorate, and variation in temperature on the potential-dependent contractile function of frog skeletal muscle

1985 ◽  
Vol 63 (6) ◽  
pp. 693-703
Author(s):  
James G. Foulks ◽  
Lillian Morishita
Keyword(s):  
Skeletal Muscle ◽  
Contractile Function ◽  
Divalent Cations ◽  
Conformational Transitions ◽  
The Other ◽  
Frog Skeletal Muscle ◽  
Solvent Structure ◽  
Opposing Effects ◽  
Kinetics Of ◽  
Reduced Temperature

D2O and perchlorate manifest opposing effects on the contractile function of skeletal muscle (amplitude of twitches and maximum K contractures, potential dependence of contraction activation and inactivation), and when combined the influence of one may effectively antagonize that of the other. The ratio of perchlorate concentrations required to produce effects of equal intensity (e.g., twitch enhancement and restoration of maximum K contractures in media lacking divalent cations or containing a depressant concentration of a cationic amphipath) in H2O and D2O solutions was generally rather constant. These findings are compatible with the view that both agents can influence contractile function by virtue of their effects on solvent structure. In the absence of divalent cations, the effects of reduced temperature resemble those of D2O whereas the effects of increased temperature resemble those of the chaotropic anion. However, in other media, variation in temperature was found to result in additional nonsolvent effects so that low temperature could oppose rather than enhance the effects of D2O. These observations are discussed in terms of a model which postulates a role for solvent influences on the kinetics of two separate potential-dependent conformational transitions of membrane proteins which mediate the activation and inactivation of contraction in skeletal muscle.

Changed cholinergic receptor characteristics after vagotomy in gastric fistula dogs

1976 ◽  
Vol 230 (1) ◽  
pp. 105-109 ◽  
Author(s):  
BI Hirschowitz ◽  
R Gibson ◽  
L Wright ◽  
G Hutchison
Keyword(s):  
Cholinergic Receptor ◽  
Cholinergic Receptors ◽  
Gastric Fistula ◽  
Irreversible Binding ◽  
Effective Stimulus ◽  
Small Doses ◽  
Before And After ◽  
Kinetics Of ◽  
Stimulation Of

By the use of small doses of atropine (0.2-10 mug/kg-h) the kinetics of atropine antagonism to the gastric stimuli Urecholine and pentagastrin could be defined in intact dogs and in dogs after fundic vagotomy. Though pentagastrin was a much less effective stimulus after vagotomy, atropine had very similar effects on the pentagastrin response before and after vagotomy. Stimulation of both acid and pepsin by Urecholine remained unchanged by vagotomy but was uncompetitively inhibited by atropine in the intact dog, suggesting irreversible binding of atropine to gastric cholinergic receptors. After vagotomy, however, atropine inhibited Urecholine competitively, suggesting that atropine was now bound reversibly to cholinergic receptors. These changes are analogous to those occurring in muscle after denervation and suggest the growth of new cholinergic receptors with changed characteristics after denervation of the stomach.

scholarly journals Kinetics of agonist-mediated transitions in state of the cholinergic receptor.

1977 ◽  
Vol 252 (21) ◽  
pp. 7648-7656 ◽  
Author(s):  
G. Weiland ◽  
B. Georgia ◽  
S. Lappi ◽  
C.F. Chignell ◽  
P. Taylor
Keyword(s):  
Cholinergic Receptor ◽  
Kinetics Of
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