Proton and phosphorus-31 nuclear magnetic resonance study on the stabilization of the anti conformation about the glycosyl bond of 8-alkylamino adenyl nucleotides

Biochemistry ◽  
1980 ◽  
Vol 19 (10) ◽  
pp. 2113-2117 ◽  
Author(s):  
Frederick E. Evans ◽  
John M. Wright
1969 ◽  
Vol 47 (3) ◽  
pp. 513-515 ◽  
Author(s):  
Ian C. P. Smith ◽  
B. J. Blackburn ◽  
Tetsuo Yamane

The temperature dependence of the nuclear magnetic resonance spectra of U, C, 5′-UMP, 5′-CMP, UpU, and CpU indicates a specific deshielding of the base proton at position-6 by an hydroxyl, phosphodiester, or phosphate group at position-5′, and demonstrates that in these compounds the bases exist in the anti conformation. Similar experiments on the wobble pair UpUpU and UpUpC suggest that the spatial arrangements of both trinucleoside diphosphates are identical, and that in these arrangements the bases are predominantly in the anti conformation.


1999 ◽  
Vol 11 (3) ◽  
pp. 871-879 ◽  
Author(s):  
A Taye ◽  
G Klotzsche ◽  
D Michel ◽  
S Mulla-Osman ◽  
R Böttcher

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