Inhibition of the classical complement pathway by synthetic peptides from the second constant domain of the heavy chain of human immunoglobulin G

Biochemistry ◽  
1981 ◽  
Vol 20 (22) ◽  
pp. 6349-6356 ◽  
Author(s):  
Michael B. Prystowsky ◽  
J. Michael Kehoe ◽  
Bruce W. Erickson
Keyword(s):  
Heavy Chain ◽  
Immunoglobulin G ◽  
Synthetic Peptides ◽  
Human Immunoglobulin ◽  
Complement Pathway ◽  
Human Immunoglobulin G ◽  
Classical Complement Pathway ◽  
Constant Domain ◽  
Classical Complement

scholarly journals The C-terminal sequences of the heavy chains of human immunoglobulin G myeloma proteins of differing isotopes and allotypes

1967 ◽  
Vol 105 (3) ◽  
pp. 1019-1028 ◽  
Author(s):  
J. W. Prahl
Keyword(s):  
Gene Duplication ◽  
Heavy Chain ◽  
Immunoglobulin G ◽  
Cyanogen Bromide ◽  
Human Immunoglobulin ◽  
Human Immunoglobulin G ◽  
Heavy Chains ◽  
Myeloma Proteins ◽  
Disease Protein ◽  
Heavy Chain Disease

The sequences of the C-terminal octadecapeptides obtained by cyanogen bromide cleavage of the γ-chains of myeloma proteins of the four subclasses, and a urinary heavy-chain-disease protein, have been determined. Although the sequences were markedly homologous, unique replacements were identified that distinguished between the γ2b, γ2c and γ2d subclasses. The data are in accord with the postulated existence of four genetic loci or cistrons, these having arisen by the process of gene duplication.

scholarly journals Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange

2014 ◽  
Vol 289 (9) ◽  
pp. 6098-6109 ◽  
Author(s):  
Theo Rispens ◽  
Anna M. Davies ◽  
Pleuni Ooijevaar-de Heer ◽  
Samira Absalah ◽  
Onno Bende ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Immunoglobulin G ◽  
Igg Subclasses ◽  
Human Immunoglobulin ◽  
Human Immunoglobulin G
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