Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin

James C. Powers; Jozef Oleksyszyn; S. Lakshmi Narasimhan; Chih Min Kam; R. Radhakrishnan; E. F. Meyer

doi:10.1021/bi00464a030

Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin

Biochemistry ◽

10.1021/bi00464a030 ◽

1990 ◽

Vol 29 (12) ◽

pp. 3108-3118 ◽

Cited By ~ 31

Author(s):

James C. Powers ◽

Jozef Oleksyszyn ◽

S. Lakshmi Narasimhan ◽

Chih Min Kam ◽

R. Radhakrishnan ◽

...

Keyword(s):

Crystal Structure ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase

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A Molecular Modeling Based upon an X-Ray Crystal Structure: The Enzyme-Ligand Complexes between Porcine Pancreatic Elastase and Acetyl-Alanine-Alanine(Glycine)-Alanine

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.19870060203 ◽

1987 ◽

Vol 6 (2) ◽

pp. 54-56

Author(s):

Tadao Fujita

Keyword(s):

Crystal Structure ◽

Molecular Modeling ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase

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Crystal Structure of an Elastase-Specific Inhibitor Elafin Complexed with Porcine Pancreatic Elastase Determined at 1.9 Å Resolution†

Biochemistry ◽

10.1021/bi960900l ◽

1996 ◽

Vol 35 (36) ◽

pp. 11570-11576 ◽

Cited By ~ 78

Author(s):

Masahiko Tsunemi ◽

Yoshiki Matsuura ◽

Shumpei Sakakibara ◽

Yukiteru Katsube

Keyword(s):

Crystal Structure ◽

Specific Inhibitor ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase

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The crystal structure of the complex of porcine pancreatic elastase with C/E-1 inhibitor, a member of a novel inhibitor family of serine proteinases

Acta Crystallographica Section A Foundations of Crystallography ◽

10.1107/s0108767378096919 ◽

1993 ◽

Vol 49 (s1) ◽

pp. c107-c107

Author(s):

K. Huang ◽

R. J. Peanasky ◽

M. N. G. James

Keyword(s):

Crystal Structure ◽

Serine Proteinases ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase

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Crystal structure of the covalent complex formed by a peptidyl α,α-difluoro-β-keto amide with porcine pancreatic elastase at 1.78 Å resolution

Peptides ◽

10.1007/978-94-010-9595-2_105 ◽

1988 ◽

pp. 344-345

Author(s):

Lori H. Takahashi ◽

R. Radhakrishnan ◽

Edgar F. Meyer ◽

Diane Amy Trainor

Keyword(s):

Crystal Structure ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase ◽

Covalent Complex

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Crystal structure of the complex of porcine pancreatic elastase with TEI-8362

Journal of Synchrotron Radiation ◽

10.1107/s0909049503023550 ◽

2003 ◽

Vol 11 (1) ◽

pp. 101-104

Author(s):

Masahiro Koizumi ◽

Emiko Muratani ◽

Katsuhiko Fujii ◽

Midori Takimoto-Kamimura

Keyword(s):

Crystal Structure ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase

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Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-ketobenzoxazoles, and the x-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazole

Journal of the American Chemical Society ◽

10.1021/ja00031a046 ◽

1992 ◽

Vol 114 (5) ◽

pp. 1854-1863 ◽

Cited By ~ 99

Author(s):

Philip D. Edwards ◽

Edgar F. Meyer ◽

J. Vijayalakshmi ◽

Paul A. Tuthill ◽

Donald A. Andisik ◽

...

Keyword(s):

Crystal Structure ◽

Design Synthesis ◽

Kinetic Evaluation ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase ◽

Covalent Complex

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ChemInform Abstract: Crystal Structure of the Covalent Complex Formed by a Peptidyl α,α-Difluoro-β-keto Amide (I) with Porcine Pancreatic Elastase at 1.78-Å Resolution

ChemInform ◽

10.1002/chin.198932315 ◽

1989 ◽

Vol 20 (32) ◽

Author(s):

L. H. TAKAHASHI ◽

R. RADHAKRISHNAN ◽

R. E. JUN. ROSENFIELD ◽

E. F. JUN. MEYER ◽

D. A. TRAINOR

Keyword(s):

Crystal Structure ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase ◽

Covalent Complex

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The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00277-7 ◽

2001 ◽

Vol 9 (3) ◽

pp. 647-651 ◽

Cited By ~ 11

Author(s):

Y Odagaki ◽

K Ohmoto ◽

S Matsuoka ◽

N Hamanaka ◽

H Nakai ◽

...

Keyword(s):

Crystal Structure ◽

Neutrophil Elastase ◽

Human Neutrophil ◽

Human Neutrophil Elastase ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase

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Crystal structure of porcine pancreatic elastase complex with novel peptidiyl trifluoromethyl ketone inhibitor of human neutrophil elastase

Acta Crystallographica Section A Foundations of Crystallography ◽

10.1107/s0108767302096605 ◽

2002 ◽

Vol 58 (s1) ◽

pp. c291-c291

Author(s):

K. Suzuki ◽

Y. Hiyama ◽

I. Fujiwara ◽

K. Tomoo ◽

T. Ishida

Keyword(s):

Crystal Structure ◽

Neutrophil Elastase ◽

Human Neutrophil ◽

Human Neutrophil Elastase ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase

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ChemInform Abstract: Design, Synthesis, and Kinetic Evaluation of a Unique Class of Elastase Inhibitors, the Peptidyl α-Ketobenzoxazoles, and the X- Ray Crystal Structure of the Covalent Complex Between Porcine Pancreatic Elastase and Ac-Ala-Pro-Val-2-Ben

ChemInform ◽

10.1002/chin.199227248 ◽

2010 ◽

Vol 23 (27) ◽

pp. no-no

Author(s):

P. D. EDWARDS ◽

E. F. JUN. MEYER ◽

J. VIJAYALAKSHMI ◽

P. A. TUTHILL ◽

D. A. ANDISIK ◽

...

Keyword(s):

Crystal Structure ◽

Design Synthesis ◽

Kinetic Evaluation ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase ◽

Covalent Complex

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