Effects of the O2' hydroxyl group on Z-DNA conformation: structure of Z-RNA and (araC)-[Z-DNA]

Biochemistry ◽  
1989 ◽  
Vol 28 (12) ◽  
pp. 4923-4928 ◽  
Author(s):  
Mai Kun Teng ◽  
Yen Chywan Liaw ◽  
Gijs A. Van der Marel ◽  
Jacques H. Van Boom ◽  
Andrew H. J. Wang
Keyword(s):  
Dna Conformation ◽  
Hydroxyl Group ◽  
Z Dna

Remodeling Chromatin Induces Z-DNA Conformation Detected through Fourier Transform Infrared Spectroscopy

2020 ◽  
Vol 92 (21) ◽  
pp. 14452-14458
Author(s):  
Yalin Li ◽  
Qing Huang ◽  
Guohua Yao ◽  
Xiaoyi Wang ◽  
Fengqiu Zhang ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Fourier Transform Infrared ◽  
Dna Conformation ◽  
Z Dna

Single C8-Arylguanine Modifications Render Oligonucleotides in the Z-DNA Conformation under Physiological Conditions

2014 ◽  
Vol 27 (7) ◽  
pp. 1176-1186 ◽  
Author(s):  
Brian C. Train ◽  
Suzan A. Bilgesü ◽  
Emily C. Despeaux ◽  
Vorasit Vongsutilers ◽  
Peter M. Gannett
Keyword(s):  
Dna Conformation ◽  
Physiological Conditions ◽  
Z Dna

scholarly journals Hydralazine induces Z-DNA conformation in a polynucleotide and elicits anti(Z-DNA) antibodies in treated patients

1993 ◽  
Vol 294 (2) ◽  
pp. 419-425 ◽  
Author(s):  
T J Thomas ◽  
J R Seibold ◽  
L E Adams ◽  
E V Hess
Keyword(s):  
Side Effects ◽  
Antibody Production ◽  
Dna Conformation ◽  
Hypertensive Patients ◽  
Supercoiled Form ◽  
Gel Retardation Assay ◽  
High Incidence ◽  
Dna Antibodies ◽  
Z Dna ◽  
Normal Controls

We studied the effect of hydralazine, an antihypertensive drug with lupus-inducing side effects, on the conformation of poly(dG-m5dC).poly(dG-m5dC) and a plasmid with a 23 bp insert of (dG-dC)n.(dG-dC)n sequences. Using an e.l.i.s.a. with a monoclonal anti-(Z-DNA) antibody Z22, we found that hydralazine provoked the Z-DNA conformation in poly(dG-m5dC).poly(dG-m5dC) at 250-500 microM concentration. The supercoiled form of hydralazine-treated plasmid bound to Z22 in a gel-retardation assay. To examine further whether Z-DNA could act as an inciting agent in anti-nuclear antibody production in patients, we analysed 65 sera from 25 hypertensive patients taking hydralazine and found anti-(Z-DNA) antibodies in 82% of these sera. Sera from age-matched normal controls showed no binding to Z-DNA. Data on sera drawn sequentially from four hypertensive patients showed that antibodies were present after the drug treatment. These data demonstrate the presence of a high incidence of anti-(Z-DNA) antibodies in patients treated with hydralazine and suggest that a possible mechanism for the production of autoantibodies in drug-related lupus might involve the induction and stabilization of Z-DNA by drugs.

scholarly journals Twisting Right to Left: A…A Mismatch in a CAG Trinucleotide Repeat Overexpansion Provokes Left-Handed Z-DNA Conformation

2015 ◽  
Vol 11 (4) ◽  
pp. e1004162 ◽  
Author(s):  
Noorain Khan ◽  
Narendar Kolimi ◽  
Thenmalarchelvi Rathinavelan
Keyword(s):  
Trinucleotide Repeat ◽  
Dna Conformation ◽  
Left Handed ◽  
Z Dna

scholarly journals Polyamine-induced Z-DNA conformation in plasmids containing (dA-dC)n.(dG-dT)n inserts and increased binding of lupus autoantibodies to the Z-DNA form of plasmids

1994 ◽  
Vol 298 (2) ◽  
pp. 485-491 ◽  
Author(s):  
T J Thomas ◽  
T Thomas
Keyword(s):  
Complex Formation ◽  
Immune Complex ◽  
Dna Conformation ◽  
Circulating Dna ◽  
Inorganic Cations ◽  
Naturally Occurring ◽  
Dna Antibodies ◽  
Z Dna ◽  
Eukaryotic Genomes ◽  
Immune Complex Formation

Blocks of potential Z-DNA-forming (dA-dC)n.(dG-dT)n sequences are ubiquitous in eukaryotic genomes. We examined whether naturally occurring polyamines, putrescine, spermidine and spermine, could provoke the Z-DNA conformation in plasmids pDHf2 and pDHf14 with 23 and 60 bp inserts respectively of (dA-dC)n.(dG-dT)n sequences using an e.l.i.s.a. Spermidine and spermine could provoke Z-DNA conformation in these plasmids, but putrescine was ineffective. For pDHf2 and pDHf14, the concentration of spermidine at the midpoint of B-DNA to Z-DNA transition was 25 microM, whereas that of spermine was 16 microM. Polyamine structural specificity was evident in the ability of spermidine homologues to induce Z-DNA. Inorganic cations, Co(NH3)6(3+) and Ru(NH3)6(3+), were ineffective. Our experiments also showed increased binding of anti-DNA autoantibodies from lupus patients as well as autoimmune MRL-lpr/lpr mice to pDHf2 and pDHf14 in the presence of polyamines. These data demonstrate that small blocks of (dA-dC)n.(dG-dT)n sequences could assume the Z-DNA conformation in the presence of natural polyamines. Increased concentrations of polyamines in the sera of lupus patients might facilitate immune complex-formation involving circulating DNA and anti-Z-DNA antibodies.

Chemical probes of DNA conformation: detection of Z-DNA at nucleotide resolution

Cell ◽  
1985 ◽  
Vol 42 (3) ◽  
pp. 713-724 ◽  
Author(s):  
Brian H. Johnston ◽  
Alexander Rich
Keyword(s):  
Dna Conformation ◽  
Chemical Probes ◽  
Z Dna ◽  
Nucleotide Resolution

First Evidence to Show the Topological Change of DNA from B-DNA to Z-DNA Conformation in the Hippocampus of Alzheimer's Brain

2002 ◽  
Vol 2 (3) ◽  
pp. 289-298 ◽  
Author(s):  
Anitha Suram ◽  
Jagannatha K. S. Rao ◽  
Latha K. S. ◽  
Viswamitra M. A.
Keyword(s):  
Dna Conformation ◽  
Topological Change ◽  
Z Dna
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